In recent years, there has been increasing interest in the use of formulations containing lipid-based excipients that comprise combinations of synthetic or semisynthetic lipids with surfactants, co-surfactants or co-solvents. This review is generally focussed on lipid-based excipients in pharmaceutical formulations which improves the oral bioavailability of poorly water-soluble drugs. Lipid-based formulations can reduce the limitations of slow and incomplete dissolution of poorly water-soluble drugs, and facilitate the formation of solubilised phases from which absorption may occur. The improvement of bio-availability of drugs is one of the greatest challenges in drug formulations. This review discusses novel lipids like Compritol 888 ATO, Dynasan 114, Glyceryl monooleate (GMO), Maisine CC and Precirol ATO 5 focussing on how these can be employed for devising efficient drug delivery systems and also the in vivo effect and fate of lipid excipients.
Cite this article:
Soma Santra, Sutapa Biswas Majee. Lipid based Vehicles and Lipid-based Excipients in Drug delivery. Research Journal of Pharmacy and Technology. 2022; 15(5):2334-8. doi: 10.52711/0974-360X.2022.00388
Soma Santra, Sutapa Biswas Majee. Lipid based Vehicles and Lipid-based Excipients in Drug delivery. Research Journal of Pharmacy and Technology. 2022; 15(5):2334-8. doi: 10.52711/0974-360X.2022.00388 Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-5-70
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