Srikrishna T., N. Harikrishnan
Srikrishna T.1,2*, N. Harikrishnan1
1Faculty of Pharmacy, Dr. M.G.R. Educational and Research Institute, Deemed to be University, Velappanchavadi, Chennai - 600077, Tamil Nadu, India.
2Ratnam Institute of Pharmacy, Pidathapolur (V&P), Muthukur (M), Nellore (Dt.) - 524346, Andhra Pradesh, India.
Volume - 15,
Issue - 5,
Year - 2022
Advanced technology is needed for quicker and better wound healing management by minimizing infection, keeping moisturizing the wound surface, speeding up tissue growth, and reducing infection at the specific area. The advancement of drug delivery in nano form is gradually increasing and shows a greater response towards healing wounds. The drug's in nano shape potential to hold the drug and facilitate rapid targeted effect in tissue growth and repair. Research outcomes confirm that shortcomings of the traditional form of dosage may be revived by nanomedicine because of its better target-specific application for wound treatment. The present analysis concentrated on further growth and applicants for medications in nano form targeting to accelerate healing of wound treatments for a different wound style. The latest development in nanomedicine has been created by different researchers in the shape of nanoparticles, niosomes, dendrimers, nanosomes, hydrogels, liposomes, and micelles, etc. which emphasize clinical value and provide better therapeutic benefits. Past few years significant development has been observed on nanomedicines to satisfy the clinical needs for chronic and wounds that are diabetic. The occurrence of wounds nonhealing gradually increasing which affects the patient mentally and financially. This current review article summarized with latest developments within the area of nanomedicine, which dramatically expanded its clinical value towards wound healing.
Cite this article:
Srikrishna T., N. Harikrishnan. Recent advancement in Nano-drug delivery for Topical Wound Healing. Research Journal of Pharmacy and Technology. 2022; 15(5):2320-6. doi: 10.52711/0974-360X.2022.00386
Srikrishna T., N. Harikrishnan. Recent advancement in Nano-drug delivery for Topical Wound Healing. Research Journal of Pharmacy and Technology. 2022; 15(5):2320-6. doi: 10.52711/0974-360X.2022.00386 Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-5-68
1. Purohit SK, Solanki R, Mathur V, Mathur M. Evaluation of wound healing activity of ethanolic extract of Curcuma longa rhizomes in male albino rats. Asian J Pharm Res. 2013;3(2):79-81.
2. Bersoff-Matcha SJ, Chamberlain C, Cao C, Kortepeter C, Chong WH. Fournier Gangrene Associated With Sodium–Glucose Cotransporter-2 Inhibitors: A Review of Spontaneous Postmarketing Cases. Ann Int Med. 2019;170(11):764-69.
3. Gosain A, DiPietro LA. Aging and Wound Healing. World J Surg. 2004;28(3):321-26.
4. Reardon S. WHO warns against'post-antibiotic'era. Nature news. 2014.
5. Kalashnikova I, Das S, Seal S. Nanomaterials for Wound Healing: Scope and Advancement. Nanomedicine. 2015;10(16):2593-612.
6. Daunton C, Kothari S, Smith L, Steele D. A History of Materials and Practices for Wound Management. Wound Practice and Research: J Australian Wound Manag Assoc. 2012;20(4):174.
7. Indalkar YR, Pimpodkar NV, Godase AS, Gaikwad PS. A compressive review on the study of nanotechnology for herbal drugs. Asian J Pharm Res. 2015;5(4):203-7.
8. Senapati S, Mahanta AK, Kumar S, Maiti P. Controlled drug delivery vehicles for cancer treatment and their performance. Signal transduction and targeted therapy. 2018 16;3(1):1-9.
9. Kohane DS, Langer R. Biocompatibility and Drug Delivery Systems. Chem Sci. 2010;1(4):441-46.
10. Mahapatro A, Singh DK. Biodegradable Nanoparticles are Excellent Vehicle for Site Directed In-Vivo Delivery of Drugs and Vaccines. J Nanobiotechnology. 2011;9(1):55.
11. Durgadevi I, Gayathri PK. Polymeric Nano Medicine for Cancer Therapy-Review. Asian J Pharm Res. 2013;4(4):264-67.
12. Moura LI, Dias AM, Leal EC, Carvalho L, de Sousa HC, Carvalho E. Chitosan-Based Dressings Loaded with Neurotensin—An Efficient Strategy to Improve Early Diabetic Wound Healing. Acta Biomater. 2014;10(2):843-57.
13. Singh NK, Singh SK, Dash D, Gonugunta P, Misra M, Maiti P. CNT Induced β-phase in Polylactide: Unique Crystallization, Biodegradation, and Biocompatibility. J Phys Chem C. 2013;117(19):10163-74.
14. Maiti P, Senapati S, Saraf S. Inhibition of Chronic Osteomyelitis using Sustained Release of Drug from Biodegradable Polymeric Chip. Clin. Oncol. 2018;3:1406.
15. Upton D, Solowiej K, Hender C, Woodyatt KY. Stress and Pain Associated with Dressing Change in Patients with Chronic Wounds. J Wound Care. 2012;21:53.
16. Calo E, Khutoryanskiy VV. Biomedical Applications of Hydrogels: A Review of Patents and Commercial Products. Eur Polymer J. 2015;65:252–67.
17. Han G, Ceilley R. Chronic Wound Healing: A Review of Current Management and Treatments. Adv Ther. 2017;34:1–12.
18. Vijayabhaskar K, Sravanprasad M, Venkateshwarlu G, Devi PS, Kumar KH, Sunil J. Wound Healing Activity of Bauhinia purpurea in Albino Wistar Rats. Asian J Pharm Res. 2011;1(2):47-9.
19. Werner S, Grose R. Regulation of Wound Healing by Growth Factors and Cytokines. Physiol Rev. 2003;83:835–870.
20. Phillipson M, Kubes P. The Neutrophil in Vascular Inflammation. Nat Med. 2011;17:1381–1390.
21. Dhalendra G, Satapathy T, Roy A. Animal models for inflammation: A review. Asian J Pharm Res. 2013;3(4):207-12.
22. Gurtner GC, Werner S, Barrandon Y, Longaker MT. Wound Repair and Regeneration. Nature. 2008;453(7193):314-21.
23. Lademann J, Richter H, Teichmann A, Otberg N, Blume-Peytavi U, Luengo J, Weiss B, Schaefer UF, Lehr CM, Wepf R, Sterry W. Nanoparticles–An Efficient Carrier for Drug Delivery into the Hair Follicles. Eur J Pharm Biopharm. 2007;66(2):159-64.
24. Pople PV, Singh KK. Development and Evaluation of Colloidal Modified Nanolipid Carrier: Application to Topical Delivery of Tacrolimus. Eur J Pharm Biopharm. 2011;79(1):82-94.
25. Tocco, I.; Zavan, B.; Bassetto, F.; Vindigni, V. Nanotechnology- Based Therapies for Skin Wound Regeneration. J. Nanomater. 2012;1−11.
26. Bawarski WE, Chidlowsky E, Bharali DJ, Mousa SA. Emerging Nanopharmaceuticals. Nanomedicine: Nanotech Biology Med. 2008;4(4):273-82.
27. Ould-Ouali L, Noppe M, Langlois X, Willems B, Te Riele P, Timmerman P, Brewster ME, Arien A, Preat V: Self-assembling PEGp (CL-co-TMC) Copolymers for Oral Delivery of Poorly Watersoluble Drugs: A Case Study With Risperidone. J Control Release 2005, 102(3):657-68.
28. Kipp JE: The Role of Solid Nanoparticle Technology in the Parenteral Delivery of Poorly Water-Soluble Drugs. Int J Pharm 2004, 284(1–2):109-122.
29. Chen X, Plasencia C, Hou Y, Neamati N. Synthesis and Biological Evaluation of Dimeric RGD Peptide-Paclitaxel Conjugate as a Model for Integrin-Targeted Drug Delivery. J Med Chem 2005,48:1098-106.
30. Amanat S, Taymouri S, Varshosaz J, Minaiyan M, Talebi A. Carboxymethyl Cellulose-Based Wafer Enriched with Resveratrol-Loaded Nanoparticles for Enhanced Wound Healing. Drug Deliv. Transl. Res. 2020;1-4.
31. Ezhilarasu H, Vishalli D, Dheen ST, Bay BH, Srinivasan DK. Nanoparticle-Based Therapeutic Approach for Diabetic Wound Healing. Nanomaterials. 2020;10(6):1234.
32. Baba R .Patent and Nanomedicine. Nanomedicine 2007; 2(3);351-374.
33. Chereddy KK, Vandermeulen G, Préat V. PLGA Based Drug Delivery Systems: Promising Carriers for Wound Healing Activity. Wound Repair and Regeneration. 2016;24(2):223-36.
34. Haque SE, Sheela A. Miscibility of Eudragit/Chitosan Polymer Blend in Water Determined by Physical Property Measurements. Int J pharm. 2013;441(1-2):648-53.
35. Dai T, Tanaka M, Huang YY, Hamblin MR. Chitosan Preparations for Wounds and Burns: Antimicrobial and Wound-Healing Effects. Expert Review of Anti-Infective Therapy. 2011;9(7):857-79.
36. Chen J, Cheng D, Li J, Wang Y, Guo JX, Chen ZP, Cai BC, Yang T. Influence of Lipid Composition on The Phase Transition Temperature of Liposomes Composed of Both DPPC and HSPC. Drug Dev Ind Pharm. 2013;39:197–204.
37. Gupta M, Goyal AK, Paliwal SR, Paliwal R, Mishra N, Vaidya B, Dube D, Jain SK, Vyas SP. Development and Characterization of Effective Topical Liposomal System for Localized Treatment of Cutaneous Candidiasis. J liposome res. 2010;20(4):341-50.
38. Nikam NR, Patil PR, Vakhariya RR, Magdum CS. Liposomes: A Novel Drug Delivery System: An Overview. Asian Pharm Res. 2020 ;10(1):23-8.
39. Mezei M, Gulasekharam V. Liposomes-A Selective Drug Delivery System for the Topical Route of Administration I. Lotion dosage form. Life Sciences. 1980;26(18):1473-77.
40. Naumov AA, Shatalin YV, Potselueva MM. Effects of A Nanocomplex Containing Antioxidant, Lipid, and Amino Acid on Thermal Burn Wound Surface. Bull. Exp. Biol. Med. 2010;149(1):62.
41. Mujariya RZ, Muzumdar A. Niosomes–An Overview. Res J Pharm Dosage Forms and Tech. 2012;4(4):202-6.
42. Makeshwar KB, Wasankar SR. Niosome: A Novel Drug Delivery System. Asian J. Pharm Res. 2013;3(1):16-20.
43. Sudheer P, Kaushik K. Review on Niosomes- A Novel Approach for Drug Targeting. J Pharm Res. 2015; 1-14.
44. Anjum S, Arora A, Alam MS, Gupta B. Development of Antimicrobial and Scar Preventive Chitosan Hydrogel Wound Dressings. Int j pharm. 2016;508(1-2):92-101.
45. Kuroiwa T, Takada H, Shogen A, Saito K, Kobayashi I, Uemura K, Kanazawa A. Cross-Linkable Chitosan-Based Hydrogel Microbeads with pH-Responsive Adsorption Properties for Organic Dyes Prepared Using Size-Tunable Microchannel Emulsification Technique. Colloids Surf, A Physicochem Eng Asp. 2017;514:69-78.
46. Bhattacharya M, Malinen MM, Lauren P, Lou YR, Kuisma SW, Kanninen L, Lille M, Corlu A, Guguen-Guillouzo C, Ikkala O. Nanofibrillar Cellulose Hydrogel Promotes Three-Dimensional Liver Cell Culture. J Control Release. 2012;164:291–8.
47. Hajimiri M, Shahverdi S, Esfandiari MA, Larijani B, Atyabi F, Rajabiani A, Dehpour AR, Amini M, Dinarvand R. Preparation of Hydrogel Embedded Polymer-Growth Factor Conjugated Nanoparticles as A Diabetic Wound Dressing. Drug Dev Ind Pharm. 2015;42:1.
48. Pachuau L. Recent Developments in Novel Drug Delivery Systems for Wound Healing. Expert Opin Drug Deliv. 2015;12:1895–909.
49. Manconi M, Manca ML, Caddeo C, Cencetti C, Meo CD, Zoratto N, Nacher A, Fadda AM, Matricardi P. Preparation of Gellan-Cholesterol Nanohydrogels Embedding Baicalin and Evaluation of Their Wound Healing Activity. Eur J Pharm Biopharm. 2018;127:244–49.
50. Amminbavi D, Lakshmi NP. Assessment of In vitro wound healing potential of Hibiscus leaf extract Emulgel. Asian J Pharm Res. 2020;10(2) 67-72.
51. Sugumar S, Mukherjee A, Chandrasekaran N. Eucalyptus Oil Nanoemulsion-Impregnated Chitosan Film: Antibacterial Effects Against A Clinical Pathogen, Staphylococcus Aureus, In Vitro. Int J Nanomed. 2015;10(Suppl 1):67.
52. Bechnak L, Khalil C, El Kurdi R, Khnayzer RS, Patra D. Curcumin Encapsulated Colloidal Amphiphilic Block Co-Polymeric Nanocapsules: Colloidal Nanocapsules Enhance Photodynamic and Anticancer Activities of Curcumin. Photochem Photobiol Sci. 2020;19(8):1088-98.
53. Negi P, Sharma G, Verma C, Garg P, Rathore C, Kulshrestha S, Lal UR, Gupta B, Pathania D. Novel Thymoquinone Loaded Chitosan-Lecithin Micelles for Effective Wound Healing: Development, Characterization, and Preclinical Evaluation. Carbohydr Polym. 2020;230:115659.
54. Stecova J, Mehnert W, Blaschke T, Kleuser B, Sivaramakrishnan R, Zouboulis CC, Seltmann H, Korting HC, Kramer KD, Schafer-Korting M. Cyproterone Acetate Loading to Lipid Nanoparticles for Topical Acne Treatment: Particle Characterisation And Skin Uptake. Pharm Res. 2007;24(5):991-1000.
55. Karthick J, Praveen Kumar PK. In-silico analysis of targeted drug delivery to hepatic cells using lipidnano-particles to treat liver diseases. Asian J Pharm Tech. 2013;3:93-7.
56. Hamdan S, Pastar I, Drakulich S, Dikici E, Tomic-Canic M, Deo S, Daunert S. Nanotechnology-Driven Therapeutic Interventions in Wound Healing: Potential Uses And Applications. ACS central sci. 2017;3(3):163-75.
57. Yildirimer L, Thanh NT, Seifalian AM. Skin Regeneration Scaffolds: A Multimodal Bottom-Up Approach. Trends Biotec. 2012;30(12):638-48.
58. Niska K., Zielinska E., Radomski M.W., Inkielewicz-Stepniak I. Metal Nanoparticles in Dermatology and Cosmetology: Interactions With Human Skin Cells. Chem. Biol. Interact. 2018;295:38–51.
59. Mankotia P, Sharma K, Sharma V, Kumar V. Interpenetrating Polymer Networks in Sustained Drug-Releasing. Adv Biopoly Syst Drug Deliv. 2020:195-232.
60. Hromadka M, Collins JB, Reed C, Han L, Kolappa KK, Cairns BA, Andrady T, van Aalst JA. Nanofiber Applications for Burn Care. J Burn Care Res. 2008;29(5):695-703.
61. Li CW, Wang Q, Li J, Hu M, Shi SJ, Li ZW, Wu GL, Cui HH, Li YY, Zhang Q, Yu XH. Silver Nanoparticles/Chitosan Oligosaccharide/Poly (Vinyl Alcohol) Nanofiber Promotes Wound Healing by Activating TGFβ1/Smad Signaling Pathway. Int J Nanomed. 2016;11:373.
62. Tan L, Hu J, Zhao H. Design of Bilayered Nanofibrous Mats for Wound Dressing Using an Electrospinning Technique. Mater letters. 2015;156:46-49.
63. Maniruzzaman M, Boateng JS, Snowden MJ, et al. A Review of Hot-Melt Extrusion: Process Technology to Pharmaceutical Products. ISRN Pharm 2012; 1–9.
64. Haque SE, Sheela A. Development of Polymer-Bound Fast-Dissolving Metformin Buccal Film with Disintegrants. Int J nanomed. 2015;10(Suppl 1):199.
65. Patel VF, Liu F, Brown MB. Advances in Oral Transmucosal Drug Delivery. J Control Release. 2011;153:106–16.
66. Sharma D, Kaur D, Verma S, et al. Fast Dissolving Oral Films Technology: A Recent Trend for an Innovative Oral Drug Delivery System. Int J Drug Deliv. 2015;7:60–75.
67. Borges AF, Silva C, Coelho JF, et al. Oral Films: Current Status and Future Perspectives: I - Galenical Development and Quality Attributes. J Control Release 2015;206:1–19.
68. Barbu E, Verestiuc L, Nevell TG, et al. Polymeric Materials for Ophthalmic Drug Delivery: Trends and Perspectives. J Mater Chem. 2006;16:3439–43.
69. Achouri D, Alhanout K, Piccerelle P, et al. Recent Advances in Ocular Drug Delivery. Drug Dev Ind Pharm. 2013;39:1599– 617.
70. Priyadharshini S, Dhivya B. Application of Nanoscience and Technology in Medicine-Nanomedicine. Res J Eng Tech. 2013;4(4): 300– 305.