Author(s): Jagdish Arun, B. Shrivastava, Swati P. Deshmukh

Email(s): swativ22d@gmail.com

DOI: 10.52711/0974-360X.2022.00381   

Address: Jagdish Arun2, B. Shrivastava2, Swati P. Deshmukh1*
1H. R. Patel Institute of Pharmaceutical Education and Research, Shirpur.
2School of Pharmaceutical Sciences, Jaipur National University, Jaipur, Rajasthan, India.
*Corresponding Author

Published In:   Volume - 15,      Issue - 5,     Year - 2022


ABSTRACT:
The Daucus carota is a scientific name of carrot and it belongs to family Apiaceae and it contains array of chemical constituent. Ethanolic extract of D. Carota showed the prominent presence of steroids, glycosides, carbohydrates, alkaloids, flavonoids, glycosides and tannins while ethyl acetate extracts showed the prominent presence of steroids, triterpenoids, falvaonids, alkaloids, carbohydrates and tannins. The anticonvulsant activity of Daucus carota seed was screen by using Pentylenetetrazole(PTZ) induced convulsions. The ethanolic extract of Daucus carota seed shows anticonvulsant activity at a dose of 200mg/kg and 400mg/kg for PTZ induce convulsion.


Cite this article:
Jagdish Arun, B. Shrivastava, Swati P. Deshmukh. Phytochemical and Pharmacological screening Daucus carota seed for its Anticonvulsant activity by using Pentylenetetrazole Induce Convulsion. Research Journal of Pharmacy and Technology. 2022; 15(5):2293-6. doi: 10.52711/0974-360X.2022.00381

Cite(Electronic):
Jagdish Arun, B. Shrivastava, Swati P. Deshmukh. Phytochemical and Pharmacological screening Daucus carota seed for its Anticonvulsant activity by using Pentylenetetrazole Induce Convulsion. Research Journal of Pharmacy and Technology. 2022; 15(5):2293-6. doi: 10.52711/0974-360X.2022.00381   Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-5-63


REFERENCES:
1.    Nair CKK Parida D K Nomura T. Radioprotectors and radiotherapy. J Radiate Res.2001; 42: 21-37.
2.    Dias  J.S. Major Classes of Phytonutriceuticals in Veg and Health Benefits: A Review. J of Nutritional Therapeutics. 2012; 1:31-62. http://dx.doi.org/10.1146/annurev.nu.06.070186.002053.
3.    Ascherson, Reinhold Conrad, A Manual Flora of Egypt, 1912; 2 44. doi.org/10.5962/bhl.title.11025.            
4.    Kirtikar K R, Basu B D. Indian Medicinal Plants. Sri Satguru Publications. Indological & Oriental publishers, 2000; 5(5): 1526-1528, 1705-1708. doi.org/ 10.31782/2231-2196.
5.    Afzal M. Comparison of protective and curative potential of Daucus carota root extract on renal ischemia reperfusion injury in rats. Pharm Biol, 2013; 51(7): 856-62.doi.org/ 10.3109/13880209.2013.767840.
6.    Coyne, T., Ibiebele. Diabetes Mellitus and Serum Carotenoids: Findings of a Population-Based Study in Queensland, Australia. The American Journal of Clinical Nutrition. 2005; 82(3): 685-693. doi.org/10.1093/ajcn/82.3.685.
7.    Chau, C.F., Chen, C.H. Comparison of the Characteristics, Functional Properties, and in Vitro Hypoglycemic Effects of Various Carrot Insoluble Fiber-Rich Fractions. Lebensmittel-Wissenshaff und Technologie. 2004; 37(7): 155-160. doi.org/10.1016/j.lwt.2003.08.001.
8.    Saura-Calixto, F.  Antioxidant Capacity of the Spanish Meditarrean Diet. Food Chemistry. 2006; 94(3): 442- 47. 10.1016/J.FOODCHEM.2004.11.033
9.    Nicolle, C., Cardinault, N. Effect of Carrot Intake on Cholesterol Metabolism and on Antioxidant Status in Cholesterol-Fed Rat. European J of Nutrition. 2003; 42(5): 254-261.doi.org 10.1007/s00394-003-0419-1.  
10.    Gilani, A.H., Shaheeri, Hypotensive Action of Coumarin Glycoside from Daucus carot. Phytomedicine. 2000; 7(5):423-426.doi.org 10.1016/s0944-7113(00)80064-1.    
11.    Bishayee, A., Sarkar, A. Hepatoprotective Activity of Carrot (Daucus carota L.) against Carbon Tetrachoride Intoxication in Mouse Liver. J of Ethnopharmacology. 1995; 47(2): 69-74.doi.org /10.1016/0378-8741(95)01254-b.
12.    Patil, M.V., Kandhare. Pharmacological Evaluation of Ethanolic Extract of Daucus carota Linn Root Formulated Cream on Wound Healing Using Excision and Incision Wound Model. Asian Pacific J. of Tropical Biomedicine.2012;2, S646-S655. http://dx.doi.org/10.4236/fns.
13.    Alves-Silva JM, Zuzarte M,  Gonçalves MJ,   Cavaleiro C, Cruz MT, Cardoso Sm and  Salgueiro L. New claims for wild carrot (Daucus carota subsp. carota)  essential oil. Evidence-Based Complementary and Alternative Medicine.2016;321-327 http://dx.doi.org/ 10.1155/2016/9045196
14.    Muralidharan, P., Balamurugan, G. Inotropic and Cardioprotective Effects of Daucus carota Linn. on Isoproterenol-Induced Myocardial Infarction. Bangladesh J of Pharmacology.2008; 3:74-79.
15.    Vasudevan, M. and Parle. Pharmalogical Evidence for Potential of Daucus carota in the Management of Cognitive Dysfunctions. Biological & Pharmaceutical Bulletin,2006;  29(6):1154-61.doi.org/ 10.1248/bpb.29.1154.
16.    Misiaka, I.J., Antifungal Activity of Carrot Seed Oil and Its Major Sesquiterpene Compounds. Zeitschrift für Naturforschung. 2004; 59(11-12):791-96.doi.org/ 10.1515/znc-2004-11-1205.
17.    Khandelwal KR. Practical Pharmacognosy: Techniques and Experiments. 10th edi, Nirali Prakashan, Pune, 2006.
18.    Kokate CK. Practical Pharmacognosy 4th edi, Vallabh Prakashan, New Delhi, 1997.149.
19.    Reed CF.  Information summaries on 1000 economic plants. Typescripts submitted to the USDA 1976.         
20.    Kumarasamy Y, Nahar  L, Byres M, Delazar  A. Sarker  S D. The assessment of biological activities associated with the major constituents of the methanol extract of 'wild carrot' (Daucus carota L) seeds. J Herb Pharmacother 2005; 5(1):61-72.doi.org /0.1080/J157v05n01_07.
21.    Meodor KJ, Ortinsket P. Cognitive side effects of antiepileptic drugs, Epilepsy & Behavior.2004; 5 (3): S60–S65.doi.org 10.1016/j.yebeh.2003.11.008.
22.    Maesh K. Senghani. Anticonvulsant Activity of Boswellic acids in Pentylenetetrazole-induced convulsive mice and Thiopental sodium sleeping time in mice.Research J. Pharm. And Tech.2013;6(9):1037-1041.
23.    Santosh Kumar, Panda,A. Venkateshwar Reddy, Mohammad Shamim Qureshi. Antiepileptogenic and Neuroprotective effect of ziziphus jujuba leaves methanolic extract against pentylenetetrazole- induced model in mice.Reserach J. Pharm. And Tech. 2018;11(1) :259-266.doi.org/10.5958/0974-360X.2020.00276.0.
24.    Sooraj Surendran, Merin Babu, Jipnomon Joseph, Uma Devi Padma. Facilitatory effect of Piperine on the Anticonvulsant effect of Sodium valproate against Pentylenetetrazole induced Seizures in mice. Research J. Pharm. And Tech.2020; 13(2):651-652.doi.org 10.5958/0974-360X.2020.00124.9.
25.    C. Ayyanna, B. Narmada, G. Suresh, D. Munaf, B. Radha, K. Bhavani, M. Anitha. Evalution of Anticonvulsant and Antioxidant activity of Flacourtia indica on Pentylenetetrazole induced convulsions in Mice. Research J. Pharm. And Tech.2020;13(4):1762-1766.doi.org/ 10.5958/0974-360X.2020.00318.2.
26.    Gerhard Vogel H and Wolf gang H: Drug discovery and evaluation pharmacological assays. Springer-Verlag Berlin Heidelberg, New York. Fourth Edition 2002. 305.
27.    Khosala P, Pandhi P. Anticonvulsant effect of namodipine alone and in combinati with diazepam on PTZ induced status epileptics. Ind. J. Pharmacol.2001; 33 (5): 208-211.doi.org 10.1358/mf.2000.22.10.802289.
28.    Bhattacharya S K, Sanyal A K.  Inhibition of pentylenetrteazole induced convulsions in rats by prostaglandin E1: role of brain monoamines. Psychopharmacology;1978;56(6): 235-237.doi.org/ 10.1007/BF00431857.
29.    Misra A K, Dandiya P C Kulkarni S K. Anticonvulsant activity of some trimethoxybezelydene -2- thyiohydantoin derivatives. Ind. J.Pharmacol.1973; 5(8):449-450.

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags


Not Available