Jaishri Kaushik, Namita Bharadwaj, Pratyush Jaiswal
Dr. Jaishri Kaushik1*, Dr. Namita Bharadwaj2, Pratyush Jaiswal3
1Assistant Professor, Department of Chemistry, LCIT College of Commerce & Science, Bilaspur (C.G.) India.
2Professor, Department of Chemistry, Dr. C.V. Raman University, Kota-495113, Dist-Bilaspur, (C.G.) India.
3Research Scholar, Department of Chemistry, Dr. C.V. Raman University, Kota-495113, Dist-Bilaspur, (C.G.) India.
Volume - 15,
Issue - 5,
Year - 2022
The Simple, selective, and expeditious spectrophotometric methods have been developed for the determination of complexation of 4-[(1R)-2-amino-1-hydroxyethyl] benzene-1,2-diol with metal ions in pharmaceutical field. The method was based on complex formation between the antihypotensive drug and transition metal ions in a basic medium (pH 9.2). The colored complexes were measured at 280 nm wavelength for 4-[(1R)-2-amino-1-hydroxyethyl] benzene-1, 2-diol. The different experimental parameters affecting the development and stability of the colour were carefully studied and optimized. The stability constant of complex were calculated to be Ag(?)-4-[(1R)-2-amino-1-hydroxyethyl] benzene-1,2-diol is 4.34, Pd (??)-4-[(1R)-2-amino-1-hydroxyethyl] benzene-1,2-diol is 5.75 & Cd (??) - 4-[(1R)-2-amino-1-hydroxyethyl] benzene-1,2-diol is 3.82 by job’s continuous variation method. The stoichiometry of the complexes formed between the antihypotensive drugs and the metal ions was 1:1 M/L ratio. The proposed method was further applied to the determination of drug in pure and dosage forms. The results obtained were in good agreement with those obtained by a reference to UV–Visible Spectrophotometric method.
Cite this article:
Jaishri Kaushik, Namita Bharadwaj, Pratyush Jaiswal. Study of Stability Constant of Some Transition Metal Complexes Formed With 4-[(1R)-2-amino-1-hydroxyethyl] benzene-1, 2-diol. Research Journal of Pharmacy and Technology. 2022; 15(5):2268-2. doi: 10.52711/0974-360X.2022.00377
Jaishri Kaushik, Namita Bharadwaj, Pratyush Jaiswal. Study of Stability Constant of Some Transition Metal Complexes Formed With 4-[(1R)-2-amino-1-hydroxyethyl] benzene-1, 2-diol. Research Journal of Pharmacy and Technology. 2022; 15(5):2268-2. doi: 10.52711/0974-360X.2022.00377 Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-5-59
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