Vats S., Agarwal K., Kumar A.
Vats S.*, Agarwal K., Kumar A.
S.D. College of Pharmacy and Vocational Studies, South Bhopa Road, Muzaffarnagar, UP, India, 251001.
Volume - 15,
Issue - 5,
Year - 2022
In India the traditional system of medicine is in practice from the ancient times for the treatment of several diseases. Due to lack of standardization or purity of herbal drugs some effective drugs are not regularly used for the treatment which is a major drawback for the herbal sector and pharma industries. That is why the standardization techniques for herbal drugs are required to be developed and make a bond with the main science health stream. There are certain preliminary guidelines given by CCRAS (Central Council for Research in Ayurveda and Siddha) for the standardization of these herbal drugs. Standardization of herbal formulations is a prime requirement for the establishment of the good quality of such herbal drugs. The present paper report the preparation and standardization of a poly herbal formulation which contain Syzygium aromaticum (flower buds), Myristica fragrans (seeds), Piper longum (fruit), Zingiber officinale (rhizome), Piper nigrum (fruit). This “Vrihatsamsharkar” churna poly herbal formulation is used in the treatment of dry cough. Following parameters like microscopy, macroscopy, ash value, extractive value, water soluble ash, bulk density, tapped density, Hausner ratio, Carr’s index, moisture content, swelling index and preliminary tests are calculated and discussed in this paper. These are certain important parameters which are necessarily required for the authentication of any herbal drug or any herbal formulation.
Cite this article:
Vats S., Agarwal K., Kumar A. Preparation and Standardization of Vrihatsamsharkar Churna: A Polyherbal Formulation. Research Journal of Pharmacy and Technology. 2022; 15(5):2244-9. doi: 10.52711/0974-360X.2022.00373
Vats S., Agarwal K., Kumar A. Preparation and Standardization of Vrihatsamsharkar Churna: A Polyherbal Formulation. Research Journal of Pharmacy and Technology. 2022; 15(5):2244-9. doi: 10.52711/0974-360X.2022.00373 Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-5-55
1. Mishra K, Shukla K, Pal P, Mahajan SC. Comparative Standardization of a Polyherbal Ayurvedic Formulation: Talisadi Churna. Research Journal of Pharmacognosy and Phytochemistry. 2015; 7(1): 34-37.doi: 10.5958/0975-4385.2015.00008.4
2. Pramod S. Shinde, Vashali J. Mahadik, Sushil M. Sarvagod. Herbal drug standardization and its implication – A current need of time. Research Journal of Pharmacognosy and Phytochemistry. 2016; 8(2): 93-100. doi: 10.5958/0975-4385.2016.00018.2
3. Das G. Bhaisajyaratnavali, 20th Edn, and enlarged by Mishra Brahmashankar and Shastri Ambikadatta, Ed. Shastri, Rajeshwardatta, Publisher Chaukhambha Prakashan, Varanasi, 2010;1247.
4. Gautam A, Sharma P. Identification, evaluation and standardization of herbal drugs: A Review, Scholars Research Library 2010; 22(6): 302-315.
5. Zhang. X. Traditional medicine, its importance and protection, In: Twarog. S.Kapoor. P. (eds). Protecting and promoting traditional knowledge: System, National experiences and International Dimensions. Part-I. The role of Traditional knowledge in Health care and Agriculture. New York; United nations, 48: p.3-6. 9.
6. Anonumous. The Ayurvedic pharmacopoeia of India. Part- II (Formulations), Vol. II, Ist ed., Ministry of Health and family Welfare, Deptt. Of AYUSH. Govt. of India, New Delhi. 2008.
7. Anonumous. The Ayurvedic Formulary of India, PartIII, Vol. II, Ist Ed., Ministry of Health and Family Welfare, Deptt. Of AYUSH, Govt. of India, New Delhi. 2011; 115.
8. Kokate CK, Purohit AP, Gokhale SB. Pharmacognosy, 45th ed., Nirali Prakashan, Pune; 2006. p. 14.13-14.83.
9. Trease and Evans. Text Book of Pharmacognosy. 15, 126.
10. Billore KV, Yelna MB, Denis TJ, and Chaudhari BG. Database on Medicinal Plants used in Ayurveda and Siddha, Vol. 6, Central Council of Research in Ayurveda and Siddha, New Delhi, 2004;374-400.
11. Bhutya RK. Ayurvedic Medicinal Plants of India, Vol. I, Scientific Publishers, Jodhpur, 2011; 109-110, 216-217.
12. Mukharjee Pulok.K. Quality control of herbal drugs: an approach to evaluation of botanicals. 3rd ed, Business Horizons Pharmaceutical Publishers; 2008.p.183-219.
13. Mukherjee P. Quality control of herbal drugs. (III) Published by business of horizons. 2009. p.282- 284.
14. WHO guidelines for assessing quality of herbal medicines with reference to contaminants and residues. World Health Organization.2007.
15. Indian Pharmacopeia Part-II Vol. II published by Indian Pharmacopeia Commission, Ghaziabad.1996. p. A-50-52.
16. Mosihuzzaman M. protocols on safety, efficacy, standardization and documentation of herbal medicine, International Union of pure and Applied Chemistry 2008; 80(10): 2195-2230.
17. Rasheed A, Reddy S. A review on standardization of herbal formulation, International Journal of Phytotherapy. 2012; 2(2): 74-88.
18. Borhade P, Khandelwal K. Review on standardization of churna, World Journal of Pharmacy and Pharmaceutical Sciences. 2012; 1(4): 1260-1274.
19. Agarwal K and Jain A. Evaluation of physicochemical standardization parameters of solena amplexicaulis leaf, Journal of Drug Delivery and Therapeutics. 2018; 8(2): 29-31
20. Rohit Kumar Bijauliya, Shashi Alok, Dilip Kumar Chanchal and Mayank Kumar, A Comprehensive review on standardization of herbal drugs, International journal of pharmaceutical sciences and research. 2017, Vol: 6, Page No: 3663-3677.
21. Rohan R. Vakhariya, Swati Talokar, Archana R. Dhole S.K. Mohite, C.S. Magdum. Comparative Standardization Study of Two Marketed Shatavari Churna Formulation. Asian J. Pharm. Ana. 6(1): January- March, 2016; Page 1-6.
22. Suraj J. Patil, Shivani D. Patil, Pratibha B. Patil, Pranali S. Patil, Ganesh B. Vambhurkar, Indryani D. Raut. Evaluation of Standardization Parameters of Ayurvedic Marketed Polyherbal Formulation. Asian J. Pharm. Ana. 2018; 8(4): 220-226.
23. Shubham Jaiswal, Sarin A. Chavhan, Sushilkumar A. Shinde, N.K. Wawge. New Tools for Herbal Drug Standardization. Asian J. Res. Pharm. Sci. 2018; 8(3): 161-169.
24. Ruchika Sharma, Neha Kumari, M.S Ashawat, C.P.S Verma. Standardization and Phytochemical Screening analysis for Herbal Extracts: Zingiber officinalis, Rosc., Curcuma longa Linn., Cinnamonum zeylanicum Nees., Piper longum, Linn., Boerhaavia diffussa Linn. Asian J. Pharm. Tech. 2020; 10(3):127-133.
25. A.K. Meena, A. K. Mangal, M. M. Rao, P. Panda, G. V. Simha, S. K. Shakya, M. M. Padhi, Ramesh Babu. Evaluation of Standardization Parameters for Sitopaladi Churna an Ayurvedic Formulation. Asian J. Research Chem. 4(12): Dec., 2011; Page 1867-1871.
26. Dubey Darshan, Dashora Kamlesh. Standardization of ‘Avipathikara Churna’: A HPLC Approach. Asian J. Research Chem. 5(12): Dec., 2012; Page 1415-1418.
27. Varun Chaddha, Avinash Singh Kushwah, Vaibhav Srivastava. Standardization and Comparative Evaluation of Shivakshar Pachan Churna: A Traditional Ayurvedic Formulation. Research Journal of Pharmacognosy and Phytochemistry. 2014; 6(2): 70-74
28. Jadhav Santosh, Sawale Jyotiram. Standardization of Poly-herbal Formulations: A Comprehensive Review. Research Journal of Pharmacognosy and Phytochemistry. 2016; 8(2): 85-89.
29. Anita S. Wanjari, Sunita Magar, Satish chapalgaokar, Namrata B. Chouragade, Dinesh S. Wanjari. Evaluation and Standardization of Herbal Formulation. Research Journal of Pharmacognosy and Phytochemistry. 2016; 8(3): 133-140.