Author(s): Elseena Jose, Anjana C. Nair, Merlin Kuttichan, Vishnu Govind A

Email(s): elseena_jose@yahoo.com

DOI: 10.52711/0974-360X.2022.00341   

Address: Elseena Jose1*, Anjana C. Nair2, Merlin Kuttichan2, Vishnu Govind A2
1Assistant Professor, Nirmala College of Pharmacy, Muvattupuzha, Kerala, India.
2Student Nirmala College of Pharmacy, Muvattupuzha, Kerala, India.
*Corresponding Author

Published In:   Volume - 15,      Issue - 5,     Year - 2022


ABSTRACT:
A simple, precise, accurate and reproducible method has been developed and validated for the estimation of Telmisartan and Rosuvastatin Calcium in their combined tablet dosage form using solvent extraction method followed by UV spectrophotometry. The absorbance was measured at 243.8nm and 295.3nm for Rosuvastatin and Telmisartan respectively. Linearity was found over the concentration range 5-25 micro gram per ml. The solvents used for the estimation were methanol for Telmisartan and phosphate buffer for Rosuvastatin. The method was statistically validated for accuracy, precision, linearity, LOD and LOQ according to ICH guidelines and can be used for analysis of combined dosage form as well as for the individual drugs.


Cite this article:
Elseena Jose, Anjana C. Nair, Merlin Kuttichan, Vishnu Govind A. Development and Validation of a Solvent Extraction UV Spectrophotometric Method for the Estimation of Rosuvastatin Calcium and Telmisartan in Combined Dosage Form. Research Journal of Pharmacy and Technology. 2022; 15(5):2065-9. doi: 10.52711/0974-360X.2022.00341

Cite(Electronic):
Elseena Jose, Anjana C. Nair, Merlin Kuttichan, Vishnu Govind A. Development and Validation of a Solvent Extraction UV Spectrophotometric Method for the Estimation of Rosuvastatin Calcium and Telmisartan in Combined Dosage Form. Research Journal of Pharmacy and Technology. 2022; 15(5):2065-9. doi: 10.52711/0974-360X.2022.00341   Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-5-23


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