Author(s): Chiquita Prahasanti, Darmawan Setijanto, Diah Savitri Ernawati, Rini Devijanti Ridwan, David Buntoro, Kamadjaja, Anita Yuliati, Asti Meizarini, Nike Hendrijantini, Agung Krismariono, Shafira Kurnia Supandi, Tania Saskianti, Ratri Maya Sitalaksmi, Djoko Kuswanto, Tansza Setiana Putri, Nastiti Faradilla Ramadhani, Muhammad Dimas Adiya Ari, Alexander Patera Nugraha

Email(s): chiquita-p@fkg.unair.ac.id

DOI: 10.52711/0974-360X.2022.00312   

Address: Chiquita Prahasanti1*, Darmawan Setijanto1, Diah Savitri Ernawati1, Rini Devijanti Ridwan1, David Buntoro, Kamadjaja1, Anita Yuliati1, Asti Meizarini1, Nike Hendrijantini1, Agung Krismariono1, Shafira Kurnia Supandi1, Tania Saskianti1, Ratri Maya Sitalaksmi1, Djoko Kuswanto2, Tansza Setiana Putri1, Nastiti Faradilla Ramadhani1,3, Muhammad Dimas Adiya Ari1, Alexander Patera Nugraha1,3,4
1Dental Implant Research Group, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
2Design Product Engineering Department, Institute Technology Sepuluh November, Surabaya, Indonesia.
3Graduate Student of Dental Health Science, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
4Orthodontics Department, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
*Corresponding Author

Published In:   Volume - 15,      Issue - 4,     Year - 2022


ABSTRACT:
Polymethyl Methacrylate (PMMA) and Hydroxyapatite (HA) utilization as single materials are rarely used as dental implant materials. There is a promising hope by combining these two materials as a dental implant fixture. Nevertheless, there is a limited information of PMMA/HA composite utilization as dental implant material. The aims of this narrative review is to describe the potential of PMMA/HA composite utilization as biomaterial candidate for porous trabecular dental implant fixture development. This narrative review finds the potential of PMMA/HA composite as biomaterial candidate for porous trabecular dental implant. The keywords "Biomaterial," "Dental Implant," "Hydroxyapatite," "Osseointegration," and "Polymethyl Methacrylate" were used in a web-based search of PubMed, NCBI, Scopus, ScienceDirect, and ResearchGate databases. PMMA is non-toxic, cost-effective, biocompatible, simple to manipulate, and has strong mechanical properties in the oral cavity. Furthermore, osteoblastic cell adhesion, development, and differentiation are aided by the use of HA as a biomaterial to induce bone formation. Nonetheless, due to its rapid absorption and degradation, single HA is seldom used as a dental implant material. Developing dental implant composite has been extensively studied, among them are the fabrication of PMMA/HA. PMMA/HA has fairly good physical characteristics with a compressive strength, good bioaffinity properties, biocompatible with bone cells. The osteoconductivity of HA enhance the bioactivity of the composite materials, thus making the dental implant to have an excellent osseointegration. We propose that there is a possibility of utilization of PMMA/HA composite as biomaterial candidate for porous trabecular dental implant fixture.


Cite this article:
Chiquita Prahasanti, Darmawan Setijanto, Diah Savitri Ernawati, Rini Devijanti Ridwan, David Buntoro, Kamadjaja, Anita Yuliati, Asti Meizarini, Nike Hendrijantini, Agung Krismariono, Shafira Kurnia Supandi, Tania Saskianti, Ratri Maya Sitalaksmi, Djoko Kuswanto, Tansza Setiana Putri, Nastiti Faradilla Ramadhani, Muhammad Dimas Adiya Ari, Alexander Patera Nugraha. Utilization of Polymethyl Methacrylate and Hydroxyapatite Composite as Biomaterial Candidate for Porous Trabecular Dental Implant Fixture Development: A Narrative Review. Research Journal of Pharmacy and Technology. 2022; 15(4):1863-9. doi: 10.52711/0974-360X.2022.00312

Cite(Electronic):
Chiquita Prahasanti, Darmawan Setijanto, Diah Savitri Ernawati, Rini Devijanti Ridwan, David Buntoro, Kamadjaja, Anita Yuliati, Asti Meizarini, Nike Hendrijantini, Agung Krismariono, Shafira Kurnia Supandi, Tania Saskianti, Ratri Maya Sitalaksmi, Djoko Kuswanto, Tansza Setiana Putri, Nastiti Faradilla Ramadhani, Muhammad Dimas Adiya Ari, Alexander Patera Nugraha. Utilization of Polymethyl Methacrylate and Hydroxyapatite Composite as Biomaterial Candidate for Porous Trabecular Dental Implant Fixture Development: A Narrative Review. Research Journal of Pharmacy and Technology. 2022; 15(4):1863-9. doi: 10.52711/0974-360X.2022.00312   Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-4-78


REFERENCES:
1.    Tyrovolas S, Koyanagi A, Panagiotakos DB, Haro JM, Kassebaum NJ, Chrepa V, Kotsakis GA. Population prevalence of edentulism and its association with depression and self-rated health. Sci Rep. 2016;6:37083.
2.    Peltzer K, Hewlett S, Yawson AE, Moynihan P, Preet R, Wu F, Guo G, Arokiasamy P, Snodgrass JJ, Chatterji S, Engelstad ME, Kowal P. Prevalence of loss of all teeth (edentulism) and associated factors in older adults in China, Ghana, India, Mexico, Russia and South Africa. Int J Environ Res Public Health. 2014;11(11):11308–11324.
3.    Pengpid S, Peltzer K. The prevalence of edentulism and their related factors in Indonesia, 2014/15. BMC Oral Health. 2018;18(1):118.
4.    Felton DA. Edentulism and comorbid factors. J Prosthodont. Feb; 2009 18(2):88–96.
5.    Hirai T, Ishijima T, Hashikawa Y, Yajima T. Osteoporosis and reduction of residual ridge in edentulous patients. J Prosthet Dent. Jan; 1993 69(1):49–56.
6.    Harsha L, Anand S. Literature Review on "Peek" Dental Implants. Research J. Pharm. and Tech 2016; 9(10):1797-1801
7.    Polzer I, Schimmel M, Müller F, Biffar R. Edentulism as part of the general health problems of elderly adults. Int Dent J. 2010 Jun;60(3):143-55. PMID: 20684439.
8.    Shah FA, Thomsen P, Palmquist A. Osseointegration and current interpretations of the bone-implant interface. Acta biomaterialia. 2019 Jan 15;84:1-5.
9.    Přikrylová J, Procházková J, Podzimek Š. Side effects of dental metal implants: impact on human health (metal as a risk factor of implantologic treatment). BioMed research international. 2019 Jul 10;2019.
10.    Goutam M, Giriyapura C, Mishra SK, Gupta S. Titanium allergy: a literature review. Indian journal of dermatology. 2014 Nov;59(6):630.
11.    Chaturvedi TP. Allergy related to dental implant and its clinical significance. Clinical, Cosmetic and Investigational Dentistry. 2013;5:57.
12.    Saini M, Singh Y, Arora P, Arora V, Jain K. Implant biomaterials: A comprehensive review. World Journal of Clinical Cases: WJCC. 2015 Jan 16;3(1):52.
13.    Kang BH, Ryu SC, Park HC. A study of the use of a hydroxyapatite and poly (methyl methacrylate) composite as a material for implants. Journal of Ceramic Processing Research. 2012;13(6):791-6.
14.    Teo AJT. Polymeric Biomaterials for Medical Implants & Devices Polymeric Biomaterials for Medical Implants and Devices. 2016.
15.    Basim SE, Mohammed RH. Al-Rubaie, Dawood SE. Studying the Affects of Salvia officinalis and Commiphora myrrha Extracts on Poly Methyl Methacrylate Acrylic (PMMA) and Flexible Acrylic Materials Exposed to Escherichia coli. Research J. Pharm. and Tech. 2019; 12(5):2407-2412.
16.    Lai W, Oka K, Jung, H. Advanced functional polymers for regenerative and therapeutic dentistry. 2015;550–557.
17.    Ali U, Karim KJBA, Buang NAA. Review of the Properties and Applications of Poly (Methyl Methacrylate) (PMMA). Polym. Rev. 2015; 55, 678–705.
18.    Zafar MS. Prosthodontic applications of polymethyl methacrylate (PMMA): An update. Polymers (Basel). 2020;12, 1–35.
19.    Alla KR. Conventional and Contemporary polymers for the fabrication of denture prosthesis: part I-Overview, composition and properties. Int. J. Appl. Dent. Sci. 1, 82–89 (2015).
20.    Arenas-Arrocena MC. New Trends for the Processing of Poly(Methyl Methacrylate) Biomaterial for Dental Prosthodontics. in Acrylic Polymers in Healthcare (2017).
21.    Deb S. Polymers in dentistry. Proc. Inst. Mech. Eng. Part H J. Eng. Med. 212, 453–464 (1998).
22.    Giavaresi G. Poly(2-hydroxyethyl methacrylate) biomimetic coating to improve osseointegration of a PMMA/HA/Glass composite implant: In vivo mechanical and histomorphometric assessments. Int. J. Artif. Organs 27, 674–680 (2004).
23.    Wijesinghe WPSL, Mantilaka, MMMGPG, Karunarathne TSEF, Rajapakse  RMG. Nanoscale Advances methacrylate) nanocomposite using dolomite. 2019; 86–88.
24.    Ramesh S, Tan CY, Aw KL, Yeo WH, Hamdi M, Sopyan I, Teng WD. Sintering behaviour of hydroxyapatite bioceramics. Med J Malaysia. 2008;63:89-90.
25.    Singh S, Pal A, Mohanty S. Nano Structure of Hydroxyapatite and its modern approach in Pharmaceutical Science. Research J. Pharm. and Tech. 2019; 12(3): 1463-1472.
26.    Jang CH, Cho YB, Choi CH, Jang YS, Jung WK, Lee JK. 2014. Comparision of osteoconductivity of biologic and artificial synthetic hydroxyapatite in experimental mastoid obliteration. Acta Otolaryngol.  134(3):255-9.
27.    Shi P, Liu M, Fan F, Yu C, Lu W, Du M. 2018. Characterization of natural hydroxyapatite originated from fish bone and its biocompatibility with osteoblasts. Mater Sci Eng C Mater Biol Appl. 90:706-712.
28.    Rincón-López JA, Hermann-Muñoz JA, Giraldo-Betancur AL, De Vizcaya-Ruiz A, Alvarado-Orozco JM, Muñoz-Saldaña J. Synthesis, Characterization and In Vitro Study of Synthetic and Bovine-Derived Hydroxyapatite Ceramics: A Comparison. Materials (Basel). 2018;25(3):11.
29.    Darwis D and Warastuti Y. Sintesis Dan Karakterisasi Komposit Hidroksiapatit (Ha) Sebagai Graft Tulang Sintetik. Jurnal Ilmiah Aplikasi Isotop dan Radiasi A Scientific Journal for The Applications of Isotopes and Radiation. 2008;4(2):144-54.
30.    Sato M, Sambito MA, Aslani A, Kalkhoran NM, Slamovich EB, Webster TJ. Increased osteoblast functions on undoped and yttrium-doped nanocrystalline hydroxyapatite coatings on titanium. Biomaterials. 2006;27:2358-2369.
31.    Kasuga T.  Coatings for metallic biomaterials. In: Niinomi, M. (Ed.), Metals for Biomedical Devices. Woodhead Publishing. 2010;11:260-282.
32.    Dubok VA. Bio ceramics–yesterday, today, tomorrow. Powder Metall Met Ceram. 2010; 39:381–394.
33.    Hench LL, Thompson I. Twenty-first century challenges for biomaterials. JR Soc Interface. 2010;7(4): S379–S391.
34.    Aprilianti NA, Rahmadhani D, Rizqianti Y, Ramadhani NF, Nugraha AP. Periodontal ligament stem cells, solcoseryl pasta incoporated nano-hydroxyapatite silica gel scaffold for bone defect regeneration in chronic periodontitis: A Review. Biochemical and Cellular Archives, 2020;20:3101–3106
35.    Dorozhkin SV. Calcium Orthophosphates Applications in Nature, Biology and Medicine. Boca Raton, FL: Pan Stanford Publishing.
36.    Saskianti T, Nugraha AP, Prahasanti C, Ernawati DS, Suardita K, Riawan W. Immunohistochemical analysis of stem cells from human exfoliated deciduous teeth seeded in carbonate apatite scaffold for the alveolar bone defect in Wistar rats ( Rattus novergicus). F1000Res. 2020;22(9):1164.
37.    Prahasanti C, Nugraha Ap, Saskianti T, Suardita K, Riawan W, Ernawati DS. Exfoliated Human Deciduous Tooth Stem Cells Incorporating Carbonate Apatite Scaffold Enhance BMP-2, BMP-7 and Attenuate MMP-8 Expression During Initial Alveolar Bone Remodeling in Wistar Rats (Rattus norvegicus). Clinical, Cosmetic and Investigational Dentistry 2020:12 79–85.
38.    Bertazzo S, Zambuzzi WF, Campos DDP, Ogeda TL, Ferreira CV, Bertran CA. Hydroxyapatite surface solubility and effect on cell adhesion. Colloids Surf B Biointerfaces. 2010;78: 177–184.
39.    Saiz E, Gremillard L, Menendez G, Miranda P, Gryn K, Tomsia AP. Preparation of porous hydroxyapatite scaffolds. Mater Sci Eng C. 2007;27: 546–550.
40.    Sanchez–Sálcedo S, Arcos D, Vallet–Regi M. Upgrading calcium phosphate scaffolds for tissue engineering applications. Key Eng Mater. 2008;377: 19–42.
41.    Kattimani VS, Kondaka S, Lingamaneni KP. Hydroxyapatite Past, Present, and Future in Bone Regeneration. Bone and Tissue Regeneration Insights. 2016;7:9-19
42.    Choudhury, P. 2012. Nanomedicine || Hydroxyapatite (HA) coatings for biomaterials. 84–127.
43.    Nugraha AP, Rezkita F, Putra KG, Narmada IB, Ernawati DS, Rantam FA. Triad Tissue Engineering: Gingival Mesenchymal Stem Cells, Platelet Rich Fibrin and Hydroxyapatite Scaffold to ameliorate Relapse Post Orthodontic Treatment. Biochem. Cell. Arch. 2019; 19(2):3689-3693
44.    Balamurugan A, Kannan S, Rajeswari S. Bioactive sol-gel hydroxyapa- tite surface for Biomedical applications – in-vitro study, Trends in Biomaterials and Artificial Organs, 2002;16:18–20.
45.    Manso M, Jimenez C, Morant C, Herrero P, Martinez-Duart JM. Electrodeposition of hydroxyapatite coatings in basic conditions, Biomaterials, 2000;21:1755–61.
46.    Tsui YC, Doyle C, Clyne TW. Plasma-sprayed hydroxyapatite coatings on titanium substrates Part 2: optimization of coating properties, Biomaterials, 1998; 19:2031–43.
47.    Tanuja B. A complete review of dental implant materials. International Journal of Recent Scientific Research. 2018;9(11):29665-9.
48.    Frazer RQ, Byron RT, Osborne PB, West KP. PMMA: An essential material in medicine and dentistry. Journal of long-term effects of medical implants. 2005;15(6):629-39.
49.    Alla RK, Raghavendra SKN, Vyas R, Tiruveedula NPB, Raju AMK. Physical and Mechanical Properties of Heat activated Acrylic Denture Base Resin Materials. Research J. Pharm. and Tech 2018; 11(6): 2258-2262
50.    Punet X, Mauchauffe R, Rodríguez-Cabello JC, Alonso M, Engel E, Mateos-Timoneda MA. Biomolecular functionalization for enhanced cell–material interactions of poly (methyl methacrylate) surfaces. Regenerative Biomaterials. 2015;2(3):167-75.
51.    Katschnig M, Maroh B, Andraschek N, Schlögl S, Zefferer U, Bock E, Leitinger G, Trattnig C, Kaufmann M, Balika W, Holzer C. Cell Morphology on Poly (methyl methacrylate) Microstructures as Function of Surface Energy. International Journal of Biomaterials. 2019;2019.
52.    Ding X, Takahata M, Akazawa T, Iwasaki N, Abe Y, Komatsu M, Murata M, Ito M, Abumi K, Minami A. Improved bioabsorbability of synthetic hydroxyapatite through partial dissolution-precipitation of its surface. Journal of Materials Science: Materials in Medicine. 2011;22(5):1247-55.
53.    Riihonen R, Nielsen S, Väänänen HK, Laitala-Leinonen T, Kwon TH. Degradation of hydroxyapatite in vivo and in vitro requires osteoclastic sodium-bicarbonate co-transporter NBCn1. Matrix Biology. 2010;29(4):287-94.
54.    Kang BH, Ryu SC, Park HC. A study of the use of a hydroxyapatite and poly (methyl methacrylate) composite as a material for implants. Journal of Ceramic Processing Research. 2012;13(6):791-6.
55.    Kwon SY, Kim YS, Woo YK, Kim SS, Park JB. Hydroxyapatite impregnated bone cement: in vitro and in vivo studies. Bio-medical materials and engineering. 1997;7(2):129-40.
56.    Che Soh NHB, Pandian S. Reactions to Acrylic Resin in Orthodontic Patient. Research J. Pharm. and Tech. 2019; 12(3): 1397-1402.
57.    Harun WS, Asri RI, Sulong AB, Ghani SA, Ghazalli Z. Hydroxyapatite-based coating on biomedical implant. Hydroxyapatite: Advances in Composite Nanomaterials, Biomedical Applications and its Technological Facets. 2018:69-88.
58.    Jung JH, Kim SY, Yi YJ, Lee BK, Kim YK. Hydroxyapatite-coated implant: Clinical prognosis assessment via a retrospective follow-up study for the average of 3 years. The Journal of Advanced Prosthodontics. 2018;10(2):85.

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags


Not Available