Author(s): Rupal S. Sanghavi, Omprakash Agrawal, Md. Rageeb Md. Usman

Email(s): bhuratrupal@gmail.com

DOI: 10.52711/0974-360X.2022.00224   

Address: Rupal S. Sanghavi1*, Omprakash Agrawal2, Md. Rageeb Md. Usman3
1Ph.D Scholar, Department of Pharmacy, Madhyanchal Professional University, Bhopal (M.P).
2Professor, Department of Pharmacy, Madhyanchal Professional University, Bhopal (M.P).
3Associate Professor, Department of Pharmacognosy, Smt. S.S Patil College of Pharmacy, Chopda (M.S.)
*Corresponding Author

Published In:   Volume - 15,      Issue - 3,     Year - 2022


ABSTRACT:
Oral route is considered as the most convenient, accepted and safest way for drug delivery, achieving better therapeutic effectiveness by delivery of drug at specific site in controlled manner is getting more attention now a days and GRDDS is one of the novel approaches which prolongs gastric residence time and releases a drug at specific targeted site of stomach for local or systemic effects. This approach is useful for drugs having narrow absorption window in upper part of GI tract. In this review we have discussed various aspects of GRDDS like merits, demerits, physiology of stomach, and potential drug candidate for GRDDS, factors affecting gastric retention, polymers and other materials used in GRDDS, Various approaches for gastric retention and evaluation of GRDDS concisely.


Cite this article:
Rupal S. Sanghavi, Omprakash Agrawal, Md. Rageeb Md. Usman. Gastroretentive Drug Delivery System: An Overview. Research Journal of Pharmacy and Technology. 2022; 15(3):1343-7. doi: 10.52711/0974-360X.2022.00224

Cite(Electronic):
Rupal S. Sanghavi, Omprakash Agrawal, Md. Rageeb Md. Usman. Gastroretentive Drug Delivery System: An Overview. Research Journal of Pharmacy and Technology. 2022; 15(3):1343-7. doi: 10.52711/0974-360X.2022.00224   Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-3-67


REFERENCES:
1.    Jimenez M, Zia H, Rhodes C. Design and testing in vitro of a bioadhesive and floating drug delivery system for oral application. International Journal of Pharmaceutics. 1994; 105: 65-70.
2.    Sakr F. A programmable drug delivery system for oral administration. International Journal of Pharmaceutics. 1999; 184: 131-139
3.    Sangalli M, Maroni A, Zema L, Busetti C, Giordano F, Gazzaniga A. In vitro and in vivo evaluation of an oral system for time and/or sitespecific drug delivery. Journal of Controlled Release. 2000; 73: 103-110.
4.    Singh B, Kim K. Floating drug delivery systems: an approach to oral controlled drug delivery via gastric retention. Journal of Controlled Release. 2000; 63: 235-259.
5.    Zakeri P, Nemati M, Ghanbarzadeh S, Hamishehkar H, Valizadeh H. Fasted state bioavailability of two delayed release formulations of divalproex sodium in healthy Iranian volunteers. Drug Research. 2011; 61: 439-43.
6.    Streubel A, Siepmann J, Bodmeier R. “Gastroretentive drug delivery system”, Expert Opinion on Drug Delivery, 3(2), 2206 217-233.
7.    Banker G, Anderson N. Tablets: The Theory and Practice of Industrial Pharmacy, 3rd Edition, Varghese Publication House.
8.    Lee T, Robinson J. Controlled Release Drug Delivery Systems. In, Gennaro AR, 20th Edition.
9.    Chen Y, Ho H, Lee T, Sheu M. Physical characterizations and sustained release profiling of gastroretentive drug delivery system with improved floating and swelling capabilities. International Journal of Pharmaceutics. 2013; 44: 162-169.
10.    Zope J, Sonawane P, Darekar A, Saudagar R. A Comprehensive Review on Gastro-Retentive Floating Drug Delivery Systems. Asian J. Pharm. Res. 2015; 5(4): 211-220.
11.    Sarika S. Lokhande. Recent Trends in Development of Gastro-Retentive Floating Drug Delivery System: A Review. Asian J. Res. Pharm. Sci. 2019; 9(2):91-96.
12.    Sarjavalagi V, Prabhat K, Harshitha A, Singh S, Narayan S. Gastroretentive Drug Delivery System: A Systematic Review. Asian J. Pharm. Tech. 2020; 10(4):278-284.
13.    Kagan L, Hoffman A. Systems for regions elective drug delivery in gastro intestinal tract: biopharmaceutical considerations. Expert Opinion. Drug Delivery. 2008; 5:681–692.
14.    Gupta P, Vermani K, Garg S. Hydrogels: From Controlled Release to pH Responsive Drug Delivery. Drug Discovery Today. 2002; 7(10):569- 579.
15.    Whitehead H, Fell J, Collett J. Development of a Gastroretentive Dosage Form. European Journal of Pharmaceutical Sciences.1996; 4 (1): 182- 186.
16.    Chien Y. Concepts and System Design for Rate Controlled Drug Delivery in Novel Drug Delivery System. 2nd Edn, New york, Marcell Dekker Inc.
17.    Vyas S, Khar R. Controlled drug delivery: concept and advances. Vallabh prakashan: Delhi.
18.    Madhusudan R, Jithan A. Advances in Drug Delivery. Med. Press, Hyderabad.
19.    Pant S, Badola A, Kothiyal P. A Review on Gastroretentive Drug Delivery System. International Journal of Research and Development in Pharmacy and Life Sciences.2016; 5 (4): 2178-2187.
20.    Gibaldi M. Bopharmaceutics and Clinical Pharmacokinetics. 4th Edition, Pharma Book Syndicate, Hyderabad.
21.    Kremser C, Albrecht K, Greindl M, Wolf C, Debbage P. In vivo determination of the time and location of mucoadhesive drug delivery systems disintegration in the gastrointestinal tract. Magnetic Resonance Imaging. 2008; 26: 638-643.
22.    Pinto J. Site-specific drug delivery systems within the gastro-intestinal tract: From the mouth to the colon. International Journal of Pharmaceutics. 2010; 395: 44-52.
23.    Rajinikanth P, Mishra B. Floating in situ gelling system for stomach site-specific delivery of clarithromycin to eradicate H. pylori. Journal of Controlled Release. 2008; 125: 33-41.
24.    Singh B. Psyllium as therapeutic and drug delivery agent. International Journal of Pharmaceutics. 2007; 334:1-14.
25.    Sungthongjeen S, Paeratakul O, Limmatvapirat S. Preparation and in vitro evaluation of a multiple-unit floating drug delivery system based on gas formation technique. International Journal of Pharmaceutics.2006; 324:136-143.
26.    Zhuang Y, Hou W, Zheng X. A MEMS based electronic capsule for time controlled drug delivery in the alimentary canal. Sensors and Actuators A: Physical. 2000; 169: 211-206.
27.    Badoni A, Ojha A. Review on gastroretentive drug delivery system. The Pharma Innovation. 2012; 1: 32-42.
28.    Larhed A, Artursson P, Grasjo J, Bjork K. Diffusion of drugs in native and purified gastrointestinal mucus. J Pharm Sci. 1997; 86(6): 660-65.
29.    Arrora S, Ali J, Khar R, Baboota S. Floatng drug delivery systems: A review. AAPS Pharm Sci Tech.2005; 6(3): 372-90.
30.    El-Kamel A, Sokar M, Al Gamal S, Naggar V. Preparation and evaluation of ketoprofen floating oral delivery system. Int J Parm. 2001; 220: 13-21.
31.    Garg S, Sharma S. Gastroretentive drug delivery systems. Business Briefing: Pharmatech.2003; 1: 160-66.
32.     Khosla R, Feely L, Davis S. Gastrointestinal transit of non-disintegrating tablets in fed subjects. Int J Pharm, 1989; 53: 107-17.
33.    Mojaverian P, Vlasses P, Kellner P, Rocci M. Effects of gender, posture and age on gastric residence time of an indigestible solid: Pharmaceutical considerations. Pharm Res. 1988; 10: 639-44.
34.    Wagh M, Joshi O, Patel J, Jain V. Thiomers: A New Generation of Mucoadhesive Polymers. Research J. Pharm. and Tech. 2009; 2(2): 250-255.
35.    Chavanpatil M, Jain P, Chaudhari S, Shear R, Vavia P. Novel sustained release, swellable and bioadhesive gastroretentive drug delivery system for ofloxacin. International Journal of Pharmaceutics. 2006; 316: 86-92.
36.    Chen R, Ho H, Yu C, Sheu M. Development of swelling/floating gastroretentive drug delivery system based on a combination of hydroxyethyl cellulose and sodium carboxymethyl cellulose for Losartan and its clinical relevance in healthy volunteers with CYP2C9 polymorphism. European Journal of Pharmaceutical Sciences. 2010; 39:82-89.
37.    Chen Y, Ho H, Lee T, Sheu M. Physical characterizations and sustained release profiling of Gastroretentive drug delivery systems with improved floating and swelling capabilities. International Journal of Pharmaceutics. 2013; 441: 162-169.
38.    Rao G, Mandapalli P, Manthri R, Reddy V. Development and in vivo evaluation of gastroretentive delivery systems for cefuroxime axetil. Saudi Pharmaceutical Journal. 2013; 21: 53-59.
39.    Cui J, Yu B, Zhao Y. Enhancement of oral absorption of curcumin by self-microemulsifying drug delivery systems”. International Journal of Pharmaceutics. 2009; 371: 148-155.
40.    Dorożyński P, Kulinowski P, Mendyk A, Jachowicz R. Gastroretentive drug delivery systems with l-dopa based on carrageenans and hydroxypropylmethylcellulose. International Journal of Pharmaceutics. 2011; 404: 169-175.
41.    Groning R, Cloer C, Georgarakis M, Muller R. Compressed collagen sponges as gastroretentive dosage forms: In vitro and in vivo studies. European Journal of Pharmaceutical Sciences. 2007; 30:1-6.
42.    Jain S, Awasthi A, Jain N, Agrawal G. Calcium silicate based microspheres of repaglinide for gastroretentive floating drug delivery: Preparation and in vitro characterization. Journal of Controlled Release. 2005; 107:300-309.
43.    Oh T, Kim J, Ha J. Preparation of highly porous gastroretentive metformin tablets using a sublimation method. European Journal of Pharmaceutics and Biopharmaceutics. 2019; 83(3), 2:460-467.
44.    Sato Y, Kawashima Y, Takeuchi H, Yamamoto H. In vitro evaluation of floating and drug releasing behaviors of hollow microspheres (microballoons) prepared by the emulsion solvent diffusion method. European Journal of Pharmaceutics and Biopharmaceutics. 2004; 57: 235-243.
45.    Chhetri H, Thapa P. A overview on Gastroretentive drug delivery system. Journal of science, engineering and technology. 2014; 1(1): 90-103
46.    Baumgartner S, Kristl J, Vrecer F, Vodopever P, Zorko R.  Review on gastroretentive drug delivery system International Journal of pharmaceutics. 2000; 1951(2):125 -135
47.    Park K, Robinson J. Bioadhessive polymers as platforms for oral controlled drug delivery: methods to study Bioadhesion. Int. J. Pharm. 1984; 19:107.
48.    He P, Davis S, Illum L. Chitosan microspheres prepared by spray drying. Int. J. Pharm. 1999; 187: 53-65
49.    Huang Y, Leobandung W, Foss A, Peppas N. Molecular aspects of muco-and bioadhesion: tethered structures and site-specific surfaces. Journal of Controlled Release. 2000; 65(1-2): 63-71.
50.    Chickering D, Mathiowitz E. Bioadhesive Drug Delivery Systems. Drugs and the Pharmaceutical Sciences. 2008; 98: 98, 1-8.
51.    Kakar S, Batra D, Singh R, Nautiyal U. Magnetic microspheres as magical novel drug delivery system: A review. Journal of Acute Disease.2013; 3: 1-12.
52.    Caldwell L, Gardner C, Cargill R. Drug delivery device which can be retained in the stomach for controlled period of time. US Patent 473 5804, 1988.
53.    Rao B, Kottan N, Snehith V, Ramesh C. Development of gastroretentive drug delivery system of cephalexin by using factorial design. ARS Pharmaceutica. 2009; 1: 50-58.
54.    Garg S, Sharma S. Gastroretentive drug delivery systems. Business Briefing: Pharmatech. 2003; 1:160-66.
55.    Hwang S, Park H, Park K. Gastroretentive delivery systems. Crit Rev Ther Drug Carrier Syst.1998; 15(3): 243-824.
56.    Reddy L, Murthy R. Floating dosage system in drug delivery. Crit Rev Ther Drug Carrier Syst.2002; 19(6): 553-85.
57.    Bhowmik D, Chiranjib B , Chandira M, Jayakar B, Kumar S. Floating drug delivery system- A Review”, Der Pharmacia Lettre. 2009; 1(2):199-218.
58.    Vyas S, Khar R. Targeted and controlled drug delivery novel carrier system. 1st edition, CBS Publishers and Distributors, New Delhi.
59.    Kumar M, Styanarayan B. A comprehensive review on gastro retentive drug delivery system. Acta Chimica Pharmaceutica Indica. 2013; 3(2):149-164.
60.    Goole J, Hamdani J, Vanderbist F, Amighi K. In vitro and in vivo evaluation in healthy human volunteers of floating riboflavin mini tablets. J. Drug Del. Sci. Tech. 2006; 16: 351.
61.    Patel N, Nagesh C, Chandrashekhar S, Patel J, Jani D. Floating drug delivery system: An innovative acceptable approach in Gastro retentive drug delivery. Asian J. Pharm. Res. 2012; 2(1):  07-18.
62.    Khatri S, Sarangi B. Emerging Trends in Floating Drug Delivery Systems. Asian J. Pharm. Res. 2014; 4(2): 65-69.
63.    Waghmare S, Kadam T, Darekar A, Saudagar R. A Review: Floatable Gastroretentive Drug Delivery System. Asian J. Pharm. Res. 2015; 5(1): 51-60.
64.    Singh B, Sharma V, Chauhan D. Gastroretentive floating sterculia-alginate beads for use in antiulcer drug delivery. Chemical Engineering Research and Design. 2010; 88: 997-1012.
65.    Sarparanta M, Bimbo L, Makila E. The mucoadhesive and gastroretentive properties of hydrophobin-coated porous silicon nanoparticle oral drug delivery systems. Biomaterials. 2012; 33: 3353-3362.
66.    Mayavanshi A, Gajjar S. Floating drug delivery systems to increase gastric retention of drugs: A Review. Research J. Pharm. and Tech.2008; 1(4): 345-348.
67.    Pawar R, Raut D, Karde V, Wadikar J, Jadhav A, Chintale A. Mucoadhesive Buccal Drug Delivery System: A Review. Research J. Pharm. and Tech. 2013; 6(5): 506-515.
68.    Naga Li, Ganga B, Krishna P.  Floating Drug Delivery Approaches for Prolonged Gastric Retention. Research J. Pharm. and Tech. 2013; 6(7): 706-710
69.    Singh B, Kim K. Floating drug delivery systems: an approach to oral controlled drug delivery via gastric retention. Journal of Controlled Release. 2000; 63:-259.
70.    Amrutkar P, Chaudhari P, Patil S. Design and in vitro evaluation of multiparticulate floating drug delivery system of zolpidem tartarate. Colloids and Surfaces B: Biointerfaces. 2012; 89: 182-187.
71.    Sungthongjeen S, Paeratakul O, Limmatvapirat S. Preparation and in vitro evaluation of a multiple-unit floating drug delivery system based on gas formation technique. International Journal of Pharmaceutics. 2006; 324:136-143
72.    Groning R, Cloer C, Georgarakis M, Muller R. Compressed collagen sponges as gastroretentive dosage forms: In vitro and in vivo studies. European Journal of Pharmaceutical Sciences. 2007; 30: 1-6.
73.    Nayak A, Das B, Maji R. Gastroretentive hydrodynamically balanced systems of ofloxacin: In vitro evaluation. Saudi Pharmaceutical Journal. 2013; 21:113-117.
74.    Tadros M. Controlled-release effervescent floating matrix tablets of ciprofloxacin hydrochloride: Development, optimization and in vitro-in vivo evaluation in healthy human volunteers. European Journal of Pharmaceutics and Biopharmaceutics. 2010; 74: 332-339.
75.    Klausner E, Eyal S, Lavy E, Friedman M, Hoffman A. Novel levodopa gastroretentive dosage form: in-vivo evaluation in dogs. Journal of Controlled Release. 2003; 88: 117-126.
76.    Sakkinen M, Marvola J, Kanerva H, Lindevall K, Ahonen A, Marvola M. Are chitosan formulations mucoadhesive in the human small intestine? An evaluation based on gamma scintigraphy. International Journal of Pharmaceutics. 2006; 307: 285-291.
77.    Pund S, Joshi A, Vasu K, Nivsarkar M, Shishoo C. Gastroretentive delivery of rifampicin: In vitro mucoadhesion and in vivo gamma scintigraphy. International Journal of Pharmaceutics. 2011;  411: 106-112
78.    Wilding I, Coupe A, Davis S. The role of γ- scintigraphy in oral drug delivery. Advanced Drug Delivery Reviews. 2001; 46:103-124.

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