Author(s): Annise Proboningrat, Viol Dhea Kharisma, Arif Nur Muhammad Ansori, Rinza Rahmawati, Amaq Fadholly, Gabrielle Ann Villar Posa, Sri Agus Sudjarwo, Fedik Abdul Rantam, Agung Budianto Achmad


DOI: 10.52711/0974-360X.2022.00209   

Address: Annise Proboningrat1, Viol Dhea Kharisma2, Arif Nur Muhammad Ansori1, Rinza Rahmawati3, Amaq Fadholly1, Gabrielle Ann Villar Posa4, Sri Agus Sudjarwo5, Fedik Abdul Rantam6,7, Agung Budianto Achmad8*
1Doctoral Program in Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, 60115, Surabaya, Indonesia.
2Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Brawijaya, 65145, Malang, Indonesia.
3Department of Chemistry, Faculty of Health Sciences, Muhammadiyah University of Surabaya, 60113, Surabaya, Indonesia.
4School of Environmental Science and Management, University of the Philippines Los Baños, Los Baños, Philippines.
5Department of Pharmacology, Faculty of Veterinary Medicine, Universitas Airlangga, 60115, Surabaya, Indonesia.
6Department of Microbiology, Faculty of Veterinary Medicine, Universitas Airlangga, 60115, Surabaya, Indonesia.
7Research Center for Vaccine Technology and Development, Institute of Tropical Disease,

Published In:   Volume - 15,      Issue - 3,     Year - 2022

Globally, the leading cause of death from cancer in women is infection with the human papillomavirus (HPV). This calls for imperative actions to explore anticancer drugs against this threatening viral infection, in which case, natural ingredients are presumed to be a promising source. Several studies show that plant-origin compounds such as allicin, apigenin, capsaicin, cyanidin, fisetin, genistein, laricitrin, naringenin, piperine, and syringetin have demonstrated therapeutic effects against several cancer types. In this study, the interaction mechanism of these compounds with HPV-18 E6 oncoprotein, that is known to downregulate tumor suppressor p53, was predicted using an in silico approach. Molecular docking simulations of natural ligands and E6 protein were performe, followed by chemical interaction analysis and 3D molecular visualization. Results indicated that fisetin is the best natural inhibitor as it has the lowest binding energy. It is highly recommended that the results of this study be used as a reference in designing anticancer drugs in vitro and in vivo.

Cite this article:
Annise Proboningrat, Viol Dhea Kharisma, Arif Nur Muhammad Ansori, Rinza Rahmawati, Amaq Fadholly, Gabrielle Ann Villar Posa, Sri Agus Sudjarwo, Fedik Abdul Rantam, Agung Budianto Achmad. In silico Study of Natural inhibitors for Human papillomavirus-18 E6 protein. Research Journal of Pharmacy and Technology. 2022; 15(3):1251-6. doi: 10.52711/0974-360X.2022.00209

Annise Proboningrat, Viol Dhea Kharisma, Arif Nur Muhammad Ansori, Rinza Rahmawati, Amaq Fadholly, Gabrielle Ann Villar Posa, Sri Agus Sudjarwo, Fedik Abdul Rantam, Agung Budianto Achmad. In silico Study of Natural inhibitors for Human papillomavirus-18 E6 protein. Research Journal of Pharmacy and Technology. 2022; 15(3):1251-6. doi: 10.52711/0974-360X.2022.00209   Available on:

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