Author(s): Hend Y. Younis, Imad A. Thanoon, Nabeel N. Fadhil, Marwan M. Merkhan

Email(s): marwanmerkhan@uomosul.edu.iq

DOI: 10.52711/0974-360X.2022.00198   

Address: Hend Y. Younis1, Imad A. Thanoon2, Nabeel N. Fadhil3, Marwan M. Merkhan4*
1Alssalam Teaching Hospital, Ninevah Health Directorate, Mosul, Iraq.
2College of Medicine, University of Mosul, Mosul, Iraq.
3College of Medicine, Ninevah University, Mosul, Iraq.
4College of Pharmacy, Ninevah University, Mosul, Iraq.
*Corresponding Author

Published In:   Volume - 15,      Issue - 3,     Year - 2022


ABSTRACT:
Type 2 diabetes mellitus (T2DM) is an insidious disorder that may progress asymptomatically, leading to secondary complications. Diabetics were found to have a significantly lower zinc level. This study aims to assess the effects of zinc supplementation for eight weeks on glycemic control, serum insulin level, serum C-peptide level, and insulin resistance. Zinc plus metformin using group had a significant decrease in fasting blood glucose level and glycated hemoglobin, as well as a significant increase in serum insulin and C-peptide levels, but no effect on insulin resistance compared to zinc-free metformin group. Comparing the two groups at the end of the study, the combined effect of zinc plus metformin was highly important versus metformin only except for C-peptide and insulin resistance. Zinc levels were significantly elevated and returned to normal in the interventional group, while in the control group, levels were rather decreased.


Cite this article:
Hend Y. Younis, Imad A. Thanoon, Nabeel N. Fadhil, Marwan M. Merkhan. Effect of Zinc as an Add-On to Metformin Therapy on Glycemic control, Serum Insulin, and C-peptide Levels and Insulin Resistance in Type 2 Diabetes Mellitus Patient. Research Journal of Pharmacy and Technology. 2022; 15(3):1184-8. doi: 10.52711/0974-360X.2022.00198

Cite(Electronic):
Hend Y. Younis, Imad A. Thanoon, Nabeel N. Fadhil, Marwan M. Merkhan. Effect of Zinc as an Add-On to Metformin Therapy on Glycemic control, Serum Insulin, and C-peptide Levels and Insulin Resistance in Type 2 Diabetes Mellitus Patient. Research Journal of Pharmacy and Technology. 2022; 15(3):1184-8. doi: 10.52711/0974-360X.2022.00198   Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-3-41


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