Author(s): Dinesh Kumar Gupta, Satish Kumar Sharma, Praveen Kumar Gaur, Alok Pratap Singh

Email(s): dineshgupta_008@rediffmail.com

DOI: 10.52711/0974-360X.2022.00181   

Address: Dinesh Kumar Gupta1,2*, Satish Kumar Sharma2, Praveen Kumar Gaur3, Alok Pratap Singh3
1Saras College of Pharmacy, Baghpat, Uttar Pradesh, 250622, India.
2Glocal School of Pharmacy, Glocal University, Saharanpur, Uttar Pradesh 247121, India.
3Department of Pharmaceutics, I.T.S College of Pharmacy, Murad Nagar, Ghaziabad, Uttar Pradesh 201206, India.
*Corresponding Author

Published In:   Volume - 15,      Issue - 3,     Year - 2022


ABSTRACT:
Lovastatin-loaded solid lipid nanoparticles were prepared by using glyceryl monostearate as lipid by solvent emulsification diffusion technique. The prepared SLNs were evaluated for particle size, shape, polydispersity index,zeta potential, percent drug loading, and in vitro release profile.The results reveal that the optimized SLNs are spherical, with a smooth surface and having particle size 298±1.1 nm, the PDI and zeta potential of optimized formulation was 0.42±0.09 and -19.1±0.81 MeV, respectively, the percent drug loading was 49.81±0.87. The optimized formulation follows Higuchi’s kinetics for drug release.


Cite this article:
Dinesh Kumar Gupta, Satish Kumar Sharma, Praveen Kumar Gaur, Alok Pratap Singh. Lovastatin Loaded Solid lipid nanoparticles for Transdermal delivery: In vitro Characterization. Research Journal of Pharmacy and Technology. 2022; 15(3):1085-9. doi: 10.52711/0974-360X.2022.00181

Cite(Electronic):
Dinesh Kumar Gupta, Satish Kumar Sharma, Praveen Kumar Gaur, Alok Pratap Singh. Lovastatin Loaded Solid lipid nanoparticles for Transdermal delivery: In vitro Characterization. Research Journal of Pharmacy and Technology. 2022; 15(3):1085-9. doi: 10.52711/0974-360X.2022.00181   Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-3-24


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