Author(s): Dwi Murtiastutik, M. Yulianto Listiawan, Lunardi Bintanjoyo, Afif Nurul Hidayati, Septiana Widyantari, Astindari, Maylita Sari

Email(s): dwimurtiastutik@yahoo.co.id

DOI: 10.52711/0974-360X.2022.00179   

Address: Dwi Murtiastutik1*, M. Yulianto Listiawan1, Lunardi Bintanjoyo1, Afif Nurul Hidayati1,2, Septiana Widyantari1, Astindari1, Maylita Sari1
1Department of Dermatology and Venereology, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo General Hospital, Surabaya 60285, Indonesia.
2Universitas Airlangga Teaching Hospital, Surabaya 60115, Indonesia.
*Corresponding Author

Published In:   Volume - 15,      Issue - 3,     Year - 2022


ABSTRACT:
Background: The long term use of antifungals for oral candidiasis (OC) in patients with Human Immunodeficiency Virus (HIV) and Acquired Immune Deficiency Syndrome (AIDS) causes some strains to be resistant to certain antifungals. HIV/AIDS are currently most common in men. Aim: To evaluate ketoconazole sensitivity on Candida species in male HIV/AIDS patients with OC. Method: This is an observational descriptive study at the Outpatient Unit and Inpatient Installation of the Infectious Disease Intermediate Care Unit (UPIPI) Dr. Soetomo, Surabaya. Samples were taken from HIV/AIDS male patients with OC using sterile swabs. The smear was cultured in CHROMagar Candida incubated at 37°C for 48-72 hours, and Sabouraud Dextrose Agar media for 48 hours at 28°C. Species identification were done using carbohydrate and Cornmeal test. Resistance test was done by disk diffusion method. Results: There were 23 research subjects with 40 isolates of Candida species growing in culture. The most common species was C. albicans in 23(57.5%) isolates, while Candida non-albicans were found in 17(42.5%) isolates. The sensitivity test results showed that 34 (85%) isolates were sensitive, while 2(5%) isolates were resistant to ketoconazole. All C. albicans (23 [100%]) and most Candida non-albicans species (11 [64%]) were sensitive to ketoconazole. Conclusion: Ketoconazole can be recommended as a treatment option for OC patients with HIV/AIDS due to the high sensitivity of both C. albicans and non-albicans to this drug.


Cite this article:
Dwi Murtiastutik, M. Yulianto Listiawan, Lunardi Bintanjoyo, Afif Nurul Hidayati, Septiana Widyantari, Astindari, Maylita Sari. Ketoconazole: A Re-emerging choice for Oral candidiasis in patients with human immunodeficiency virus infection/acquired Immunodeficiency Syndrome. Research Journal of Pharmacy and Technology. 2022; 15(3):1071-6. doi: 10.52711/0974-360X.2022.00179

Cite(Electronic):
Dwi Murtiastutik, M. Yulianto Listiawan, Lunardi Bintanjoyo, Afif Nurul Hidayati, Septiana Widyantari, Astindari, Maylita Sari. Ketoconazole: A Re-emerging choice for Oral candidiasis in patients with human immunodeficiency virus infection/acquired Immunodeficiency Syndrome. Research Journal of Pharmacy and Technology. 2022; 15(3):1071-6. doi: 10.52711/0974-360X.2022.00179   Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-3-22


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