Author(s): Ahmed S. Mancy, Sara Shaheen, Ayman Albaghdady, Nagwa A. Sabri

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DOI: 10.52711/0974-360X.2022.00177   

Address: Ahmed S. Mancy1*, Sara Shaheen2, Ayman Albaghdady3, Nagwa A. Sabri2
1Department of Pharmacy Practice, Faculty of Pharmacy, Heliopolis University, Cairo, Egypt.
2Department of Clinical Pharmacy, Faculty of Pharmacy, Ain-Shams University, Cairo, Egypt.
3Department of Pediatric Surgery, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
*Corresponding Author

Published In:   Volume - 15,      Issue - 3,     Year - 2022

Purpose: The aim of this study was to ensure the safety and efficacy of intravenous administration of colistin-imipenem/cilastatin combination to critically ill pediatrics suffering from multidrug-resistant gram-negative sepsis. Patients and methods: The study was designed to give sixty patients in Al-Demerdash hospital pediatric intensive care units (PICU), Ain Shams University, Cairo, Egypt, either imipenem/cilastatin as a monotherapy (thirty patients) or colistin-imipenem/cilastatin intravenously as a combination (thirty patients). The interventional prospective randomized study was performed with focusing on patients' hemodynamic parameters, vital signs, sepsis markers and microbiological response. Results: Thirty patients received intravenous colistin-imipenem/cilastatin combination; with median age of 8.5 months (range: 1-36 months). The isolated bacteria were Acinetobacter baumannii, Klebsiella pneumoniae, Pseudomonas aeruginosa and Escherichia coli. Klebsiella pneumoniae was the most common isolate (51.7%) of the overall examined sixty patients. Patient who received the combination therapy, was associated with improving in vital signs and hemodynamic parameters with significant p = 0.001, and microbiological responses were represented by the recorded cultures. No patients were defined by renal impairment or neurological toxicity as a side effect to colistin therapy. However, non-significant differences in fatality was found among the two groups with p = 0.108. Conclusion: Colistin combination therapy resulted in better clinical outcomes of PICU patients, which were represented by eradication of the multidrug-resistant gram-negative bacteria without noticeable nephrotoxicity.

Cite this article:
Ahmed S. Mancy, Sara Shaheen, Ayman Albaghdady, Nagwa A. Sabri. Efficacy and safety of Colistin-Imipenem/Cilastatin combination Therapy for Multidrug-Resistant Gram-Negative Bacteria Infections in Critically Ill Pediatric Patients. Research Journal of Pharmacy and Technology. 2022; 15(3):1059-3. doi: 10.52711/0974-360X.2022.00177

Ahmed S. Mancy, Sara Shaheen, Ayman Albaghdady, Nagwa A. Sabri. Efficacy and safety of Colistin-Imipenem/Cilastatin combination Therapy for Multidrug-Resistant Gram-Negative Bacteria Infections in Critically Ill Pediatric Patients. Research Journal of Pharmacy and Technology. 2022; 15(3):1059-3. doi: 10.52711/0974-360X.2022.00177   Available on:

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