Mohammad Habeeb, K.L. Deepthi, M. Vijaya Vara Prasad, N. Irfan, Shaik Liakhat Ali, K. Navyaja
Mohammad Habeeb1*, K.L. Deepthi2, M. Vijaya Vara Prasad3, N. Irfan3, Shaik Liakhat Ali4, K. Navyaja5
1Department of Pharmaceutics, Crescent School of Pharmacy, B.S. Abdur Rahman Crescent Institute of Science and Technology, Vandalur, Chennai, Tamilnadu, India.
2Department of Pharmaceutics, Raghu college of Pharmacy, Visakhapatnam, AndhraPradesh, India.
3Department of Pharmaceutical Chemistry, Crescent School of Pharmacy, B.S. Abdur Rahman Crescent Institute of Science and Technology, Vandalur, Chennai, Tamilnadu, India.
4Department of Pharmacology, Vignan Pharmacy college, Vadlamudi,Guntur, Andhra Pradesh. India.
5Department of Pharmacognosy, Institute of Pharmaceutical Technology, Sri Padmavati Mahila Visvavidyalayam, Tirupati, Andhra Pradesh, India.
Volume - 15,
Issue - 2,
Year - 2022
This work mainly aimed to develop bilayer tablets of drug Metoclopramide HCl and Tramadol HCl with the aid of various polymers such as Guar gum, HPMC, Na CMC and Xanthan gum, either alone or in mixtures. Tablets were ready by instant unleash direct compression and sustained release wet granulation methodology and assessed for numerous physical parameters. The drug unleashes studies were performed exploitation USP equipment sort exploitation zero. 1N HCl and pH scale 6.8 phosphate buffers as dissolution medium. Drug unleash was quicker from Metoclopramide layer and tramadol combination with HPMC, Na CMC, Guargum with Xanthan gum it continuous drug unleash efficiently. The fitting the dissolution approach, initial order, Hixson Crowell and Higuchi, Korsmeyer-Peppas equations were used to analyze the speed and unleash mechanism of Tramadol HCl. Results showed that zero-order unleash Mechanism was followed by F1-F10 formulations. The plots (Higuchi) for all the designs remained rectilinear representing the drug unleash by diffusion controlled. Hixon-Crowell root model showed high r2 price proportion because of hydrophobicity of the gel layer erosion. The discharge configuration, consequences of the in-vitro dissolution information stood fitted to the Korsmeyer-Peppas equation that illustrates the delivery mechanism directs the non fickian transport it confers with a combination of each diffusion and erosion rate delivery. The results concluded that the formulation F10 will improve patient compliance in pain and gastro esophageal reflex and also provides higher wellness management.
Cite this article:
Mohammad Habeeb, K.L. Deepthi, M. Vijaya Vara Prasad, N. Irfan, Shaik Liakhat Ali, K. Navyaja. Development Characterization and Molecular Simulation studies of Metoclopramide HCl and Tramadol HCl Bilayer Tablets. Research Journal of Pharmacy and Technology. 2022; 15(2):529-4. doi: 10.52711/0974-360X.2022.00085
Mohammad Habeeb, K.L. Deepthi, M. Vijaya Vara Prasad, N. Irfan, Shaik Liakhat Ali, K. Navyaja. Development Characterization and Molecular Simulation studies of Metoclopramide HCl and Tramadol HCl Bilayer Tablets. Research Journal of Pharmacy and Technology. 2022; 15(2):529-4. doi: 10.52711/0974-360X.2022.00085 Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-2-5
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