Author(s): Braham Dutt, Manjusha Choudhary, Vikas Budhwar

Email(s): dutt007.rs.pharma@mdurohtak.ac.in , manjushachoudhary@gmail.com , vikaasbudhwar@yahoo.com

DOI: 10.52711/0974-360X.2022.00128   

Address: Braham Dutt1, Manjusha Choudhary2, Vikas Budhwar1*
1Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak - 124001, India.
2University Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra, India – 136119.
*Corresponding Author

Published In:   Volume - 15,      Issue - 2,     Year - 2022


ABSTRACT:
Cocrystallization process is a well-known technique for altering the pharmaceutical properties of drugs without modifying their actual pharmacological actions. Availability of a number of potential coformers make this technique more useful for implementation in pharmaceutical research area on newer and older API’s having pharmaceutical issues like poor solubility, stability profiles etc. Aspirin is a long-known antipyretic and anti-inflammatory drug belonging to BCS Class II having poor aqueous solubility. This API undergoes hydrolysis at higher temperature and in humid environment with the resultant degradation products being salicylic acid and acetic acid. Cocrystalization technique could be useful for improving its stability profile as the physicochemical properties of drugs get modified by their cocrystallization with coformers having better thermal stability as well higher solubility profile than API’s. In this study, aspirin and benzoic acid have been cocrystallized in a fixed stochiometric ratio (1:2) for improving its stability issues. Differential Scanning Calorimetry (DSC), Infra-Red spectroscopy technique (FTIR) and X-ray Diffraction (XRD) technique were used for analysis of cocrystals. Dissolution study was performed which revealed an improved dissolution profile of cocrystals compared to pure drug aspirin. Accelerated stability study was performed as per ICH guidelines for 6 months and stability profile of drug and cocrystals were compared by using HPLC technique, which exhibited a better stability profile of cocrystals compared to pure drug.


Cite this article:
Braham Dutt, Manjusha Choudhary, Vikas Budhwar. Enhancement of Stability profile of Aspirin through Cocrystallization Technique. Research Journal of Pharmacy and Technology. 2022; 15(2):768-2. doi: 10.52711/0974-360X.2022.00128

Cite(Electronic):
Braham Dutt, Manjusha Choudhary, Vikas Budhwar. Enhancement of Stability profile of Aspirin through Cocrystallization Technique. Research Journal of Pharmacy and Technology. 2022; 15(2):768-2. doi: 10.52711/0974-360X.2022.00128   Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-2-48


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