Vaibhav Gulabrao Bhamare, Ravindra Keshavrao Kamble
Vaibhav Gulabrao Bhamare1*, Ravindra Keshavrao Kamble2
1Department of Pharmaceutics, K. K. Wagh College of Pharmacy, Panchavati, Nashik, 422003, Maharashtra, India.
2Department of Pharmaceutics, Faculty of Pharmacy, Bhupal Nobles’ University, Old Station Road, Udaipur- 313001. Rajasthan, India.
Volume - 15,
Issue - 2,
Year - 2022
Solubility and dissolution is an essential requirement for any drug to perform well in vivo. The present research was undertaken to enhance the dissolution rate of poor water soluble drug Etodolac through solid dispersion and complexation technique. Fusion method and kneading methods were employed for solubility enhancement by Solid Dispersion technique and complexation technique respectively. PEG-6000, HPMC K4M, ß-Cyclodextrin and PVPK-30 are used as carriers. Physical mixtures were prepared in different ratio of drug and carriers. The prepared blends were evaluated for solubility, drug content, percent yield and drug release. Solubility enhancement was observed for all the experimental mixtures having maximum attainment for polymers PEG 6000 and PVPK-30. Pre and post enhancement Etodolac solubility values confirm the successful modification in solubility of drug through solid dispersion technique and complexation technique with slight edge toward complexation technique.
Cite this article:
Vaibhav Gulabrao Bhamare, Ravindra Keshavrao Kamble. Modified Solubility of Etodolac through Solid Dispersion and Complexation. Research Journal of Pharmacy and Technology. 2022; 15(2):683-8. doi: 10.52711/0974-360X.2022.00113
Vaibhav Gulabrao Bhamare, Ravindra Keshavrao Kamble. Modified Solubility of Etodolac through Solid Dispersion and Complexation. Research Journal of Pharmacy and Technology. 2022; 15(2):683-8. doi: 10.52711/0974-360X.2022.00113 Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-2-33
1. Verma S, et al. Solid Dispersion: A Strategy for Solubility Enhancement. International Journal of Pharmacy and Technology. 2011; 3: 1062-1099.
2. Brahmankar DM, Jaiswal SB. Biopharmaceutics and Pharmacokinetics a Treatise. Vallabh Prakashan, Delhi. 2006.
3. Giri TK, et al. Carriers used for the development of solid dispersion for poorly water soluble drugs. Research Journal of Pharmacy and Technology. 2011; 4(3): 356-366.
4. Venkatesh N, et al. Solid dispersions, a unique technique to improve the aqueous solubility of poorly soluble drugs- A review. International Journal of Pharmaceutical Research. 2008; 1: 5-12.
5. Chiou, WL, Riegelman S. Preparation and dissolution characteristics of several fast-release solid dispersions of griseofulvin. Journal of Pharmaceutical Sciences.1969; 58: 1505-1509.
6. Manukonda K, et al. Solid Dispersions - An Approach to Enhance the Dissolution Rate of Clopidogrel Bisulphate. Asian Journal of Research in Pharmaceutical Sciences. 2014; 4(4): 165-168.
7. Daisy S, et al. Solubility Enhancement – Eminent Role in Poorly Soluble Drugs. Research Journal of Pharmacy and Technology. 2009; 2(2): 220-224.
8. Ford JL. The current status of solid dispersions. Pharmaceutica Acta Helvetiae.1986;61:69-88.
9. Ozkan Y, et al. Enhanced release of solid dispersions of Etodolac in polyethylene glycol. Il Farmaco: An International Journal of Medicinal Chemistry and Pharmaceutical Chemistry; 55(6-7): 433-8.
10. Leuner C, Dressman J. Improving drug solubility for oral delivery using solid dispersions. European Journal of Pharmaceutics and Biopharmaceutics. 2000; 50: 47-60.
11. Chiou WL, Riegelman S. Pharmaceutical applications of solid dispersion systems. Journal of Pharmaceutical Sciences. 1971; 60: 1281- 1302.
12. Pilli R, et al. Enhancement of the dissolution rate and bioavailability of etodolac in solid dispersions by cyclodextrin complexes. Research Journal of Pharmaceutical, Biological and Chemical Sciences. 2014; 5(6): 7-23
13. Rai SK, et al. Salts and Cocrystal of Etodolac: Advantage of Solubility, Dissolution, and Permeability. Crystal, growth and Design. 2020; 20(7): 4512-4552.
14. Saffoon N, et al. Enhancement of oral bioavailability and solid dispersion: a review. Journal of Applied Pharmaceutical Science. 2011; 1(7): 13-20.
15. Singh J, et al. Solubility enhancement by solid dispersion method: a review. Journal of Drug Delivery and Therapeutics.2013; 3(5): 148-155.
16. Bhairav BA, et al. Review on Solubility Enhancement Techniques. Asian Journal of Pharmaceutical Research. 2016; 6(3): 147-152
17. Huang Y, Dai WG. Fundamental aspects of solid dispersion technology for poorly soluble drugs. Acta Pharmaceutica Sinica B. 2014; 4(1): 18-25.
18. Singh MC, et al. Review on various techniques of solubility enhancement of poorly soluble drugs with special emphasis on solid dispersion. Journal of Pharmacy Research. 2010; 3(10): 2494-2501.
19. Gurunath S, et al. Amorphous solid dispersion method for improving oral bioavailability of poorly water-soluble drugs. Journal of Pharmacy Research. 2013; 6(4): 476-480.
20. Reddy MKK, et al. Study on effect of excipients in enhancing the solubility of nateglinide by solid dispersions. Asian Journal of Pharmaceutical Research.2012; 2(4): 144-147.
21. Shaikh FI, et al. Preparation and Characterization of Lercanidipine Hydrochloride Inclusion complex with β-cyclodextrin and effect of Complexation on Solubility and Dissolution. Research Journal of Pharmacy and Technology. 2017; 10(4): 1041-1048
22. Hajare AA, Jadhav PR. Improvement of Solubility and Dissolution Rate of Indomethacin by Solid Dispersion in Polyvinyl Pyrrolidone K30 and Poloxomer 188. Asian Journal of Pharmacy and Technology. 2012;2(3): 116-122
23. Yadav AV, Yadav BV. Improvement of Physicochemical properties of Mesalamine with Hydrophilic Carriers by Solid Dispersion (kneading) method. Research Journal of Pharmacy and Technology. 2008; 1(4):422-425
24. Patil GB, et al. Studies on Occlusion Complexes of Aceclofenac with β-Cyclodextrin and Hydroxypropyl -β- Cyclodextrin. Research Journal of Pharmaceutical Dosage Forms and Technology. 2009; 1(3):200-203