Author(s): Gayathri S Prabhu, Anoop Kishore, Keerthana Prasad, Mohandas Rao K.G, Kiranmai S Rai

Email(s): kiranmai.rai@manipal.edu

DOI: 10.52711/0974-360X.2022.00110   

Address: Gayathri S Prabhu1, Anoop Kishore2, Keerthana Prasad3, Mohandas Rao K.G4, Kiranmai S Rai5*
1,4Department of Anatomy, Melaka Manipal Medical College (Manipal Campus), Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, India - 576104.
2Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, India - 576104.
3Manipal School of Information Sciences, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, India - 576104.
5*Department of Physiology, Melaka Manipal Medical College (Manipal Campus), Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, India - 576104.
*Corresponding Author

Published In:   Volume - 15,      Issue - 2,     Year - 2022


ABSTRACT:
Childhood obesity increases body mass index and long term metabolic disturbances. The present study is designed to analyze postnatal obesity-induced changes in body mass index and common carotid artery wall thickness and the role of dietary choline and DHA or environmental enrichment in mitigating these changes. Four groups of male rat pups (n=8/group) were assigned as Normal control (NC), Obese (OB) fed high-fat diet, Obesity-induced supplemented choline and DHA (OB+CHO+DHA) with 5mmol/kg/day of choline and 150 mg/ day of DHA, Obesity-induced environmental enrichment (OB+EE) exposed to environmental enrichment for 90 days. Body mass index was calculated after 90 days. Subsequently, rats were euthanized to excise common carotid artery. 5µ thick sections were processed for haematoxylin and eosin and Verhoff –Vangeison stains. Mean body weight, body mass index, thickness of tunica intima, media and percentage of collagen fibers in artery were significantly higher in OB group (p< 0.01, <0.001,< 0.01, < 0.001, < 0.05) as compared to the same in NC rats respectively. These changes were significantly (p<0.01, < 0.05) attenuated in OB+CHO+DHA and OB+EE groups compared to OB rats. Increased body mass index in early ages is an indicator for atherosclerosis. Supplementation of dietary choline and DHA or environmental enrichment exposure attenuates these changes from an early young age.


Cite this article:
Gayathri S Prabhu, Anoop Kishore, Keerthana Prasad, Mohandas Rao K.G, Kiranmai S Rai. Protective role of Dietary Choline and Docosahexaenoic acid or Environmental enrichment in attenuating high fat diet-induced arterial wall changes in obese rats. Research Journal of Pharmacy and Technology. 2022; 15(2):665-0. doi: 10.52711/0974-360X.2022.00110

Cite(Electronic):
Gayathri S Prabhu, Anoop Kishore, Keerthana Prasad, Mohandas Rao K.G, Kiranmai S Rai. Protective role of Dietary Choline and Docosahexaenoic acid or Environmental enrichment in attenuating high fat diet-induced arterial wall changes in obese rats. Research Journal of Pharmacy and Technology. 2022; 15(2):665-0. doi: 10.52711/0974-360X.2022.00110   Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-2-30


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