Author(s): K. Sruthi, B. Anupama, N.L. Sudeepthi, P. Gopi Krishna, Abdul Kareem, Mohammad Habeeb

Email(s): sruthidms68@gmail.com

DOI: 10.52711/0974-360X.2022.00106   

Address: K. Sruthi1*, B. Anupama2, N.L. Sudeepthi2, P. Gopi Krishna2, Abdul Kareem2, Mohammad Habeeb3
1Department of Pharmaceutical Chemistry, Vijaya Institute of Pharmaceutical Sciences for Women, Vijayawada, Andhra Pradesh, India.
2Department of Pharmaceutical Chemistry, KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada, Andhra Pradesh, India.
3Department of Pharmaceutics, Crescent School of Pharmacy, B.S. Abdur Rahman Crescent Institute of Science and Technology, Vandalur, Chennai, Tamilnadu, India.
*Corresponding Author

Published In:   Volume - 15,      Issue - 2,     Year - 2022


ABSTRACT:
There are many drugs for alopecia such as minoxidil, glucocorticoids, sulfasalazine, nitric oxide, and vitamin D3. Hair loss is also known as alopecia, or baldness commonly refers to hair loss from either a portion of a head or body. Fresh Leaves, and bark from twigs of Wrightia tinctoria were taken and used for extraction. A phytochemical assessment was continued to carry out on W.tinctoria extract and the presence of aromatic hydrogen and aromatic protons was demonstrated by spectral characterization. Insilco studies were done. Compounds 1and6 shown more docking values than the minoxidil and Swiss ADME confirmed that the compounds can enter the blood-brain barrier and not the substrates of PgP carriers. In vivo evaluation of alopecia activity using albino male, Wistar rats were done by comparing it with standard drug involves the evaluation of in vivo hair development activities of W.tinctoria extract. It also involves histopathological studies which include the action of hair growth at anagen and telogen phases on 15th and 30th day. The study indicates that the material elements of W.tinctoria which include Quercetin and Indirubin playing a critical role in hair promoting activity.


Cite this article:
K. Sruthi, B. Anupama, N.L. Sudeepthi, P. Gopi Krishna, Abdul Kareem, Mohammad Habeeb. Investigation of Wrightia tinctoria extract activity on Alopecia using In-silco and In-vivo studies. Research Journal of Pharmacy and Technology. 2022; 15(2):643-9. doi: 10.52711/0974-360X.2022.00106

Cite(Electronic):
K. Sruthi, B. Anupama, N.L. Sudeepthi, P. Gopi Krishna, Abdul Kareem, Mohammad Habeeb. Investigation of Wrightia tinctoria extract activity on Alopecia using In-silco and In-vivo studies. Research Journal of Pharmacy and Technology. 2022; 15(2):643-9. doi: 10.52711/0974-360X.2022.00106   Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-2-26


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