Author(s): L. Perekhoda, M. Hari Krishna, T. Sekhar, A. Venkateswarlu, P. Thriveni, M. Suleiman, A. Semenets, A. Fedosov, L. Grinevich, N. Kobzar, V. Yaremenko

Email(s): suleiman.nfau@outlook.com

DOI: 10.52711/0974-360X.2022.00091   

Address: L. Perekhoda2, M. Hari Krishna1, T. Sekhar1, A. Venkateswarlu1, P. Thriveni1, M. Suleiman2, A. Semenets2, A. Fedosov2, L. Grinevich2, N. Kobzar2, V. Yaremenko2
1Department of Chemistry, Vikrama Simhapuri University, Nellore-524001, Andhra Pradesh, India.
2Department of Medicinal Chemistry, National University of Pharmacy, Pushkinska 53, 61002, Kharkiv, Ukraine.
*Corresponding Author

Published In:   Volume - 15,      Issue - 2,     Year - 2022


ABSTRACT:
A series of 3-substituted guinazolinone derivatives have been synthesized in good to excellent yields and high selectivity by one-pot reaction using anthranilic acid, amine and orthoester in ethanol under mild conditions, respectively. The reaction was efficiently promoted by Bi(OTf)3 and the catalyst could be recovered easily after the reactions and reused without evident loss of reactivity. Docking studies have shown that the tested molecules have an affinity for anticancer targets. The data obtained can be used in planning experimental screening for antitumor activity.


Cite this article:
L. Perekhoda, M. Hari Krishna, T. Sekhar, A. Venkateswarlu, P. Thriveni, M. Suleiman, A. Semenets, A. Fedosov, L. Grinevich, N. Kobzar, V. Yaremenko. Prediction of antitumor activity of 3-substituted quinazolinone derivatives synthesized in one-pot method catalyzed by Bi(OTf)3. Research Journal of Pharmacy and Technology. 2022; 15(2):559-5. doi: 10.52711/0974-360X.2022.00091

Cite(Electronic):
L. Perekhoda, M. Hari Krishna, T. Sekhar, A. Venkateswarlu, P. Thriveni, M. Suleiman, A. Semenets, A. Fedosov, L. Grinevich, N. Kobzar, V. Yaremenko. Prediction of antitumor activity of 3-substituted quinazolinone derivatives synthesized in one-pot method catalyzed by Bi(OTf)3. Research Journal of Pharmacy and Technology. 2022; 15(2):559-5. doi: 10.52711/0974-360X.2022.00091   Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-2-11


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