Author(s): Gustiadi Saputra, Alexander Patera Nugraha, Theresia Indah Budhy, Fransisca Shancti Rosari, Nur Aini Indah Lestari, Alifiya Afita Sari, Afiqah Gheasani, Theodora Valensia, Nastiti Faradilla Ramadhani, Tengku Natasha Eleena Binti Tengku Ahmad Noor, Albertus Putera Nugraha, Andreas Pratama Nugraha, Agung Sosiawan

Email(s): alexander.patera.nugraha@fkg.unair.ac.id

DOI: 10.52711/0974-360X.2022.00995   

Address: Gustiadi Saputra1, Alexander Patera Nugraha2,3,4*, Theresia Indah Budhy2, Fransisca Shancti Rosari3, Nur Aini Indah Lestari5, Alifiya Afita Sari5, Afiqah Gheasani5, Theodora Valensia5, Nastiti Faradilla Ramadhani4,6, Tengku Natasha Eleena Binti Tengku Ahmad Noor7,8, Albertus Putera Nugraha9, Andreas Pratama Nugraha10,11, Agung Sosiawan12
1Graduate Student of Immunology, Postgraduate School of Universitas Airlangga, Surabaya, Indonesia.
2Immunology Study Program, Postgraduate School of Universitas Airlangga, Surabaya, Indonesia.
3Orthodontics Department, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
4Graduate Student of Dental Health Science, Universitas Airlangga, Surabaya, Indonesia.
5Undergraduate Student, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
6Dentomaxillofacial Radiology, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
7Malaysian Armed Forces Dental Officer, 609 Armed Forces Dental Cli

Published In:   Volume - 15,      Issue - 12,     Year - 2022


ABSTRACT:
Periodontal disease is oral health problem which attacks 20-50% of the global population. In Indonesia, 60% population suffers periodontal disease and become the second most common disease in the oral cavity. Aggressive periodontitis (AP) is one of periodontal disease, mainly attacks individual under 30 years-old, with rapid alveolar bone destruction. Bone graft implantation surgery is the current treatment for AP, but it is invasive and high risk infection. Nanohydroxyapatite-chitosan (nHPA-CS) hydrogel injectable scaffold is non-invasive treatment that contains bone mineral hydroxyapatite that derived from bovine bone and chitosan (CS) biopolymer with low immunogenicity. Platelet-Rich-Fibrin (PRF) contains huge amount growth factor which is biodegradable to human body. Buccal-Fat-Pad Stem-Cell (BFPSC) was chosen because it is easy to harvest and able to differentiate into mesenchymal lineage tissue. The aim of this narrative review is to describe the potential combination of nanohydroxyapatite-chitosan hydrogel scaffold, platelet-rich-fibrin, and buccal-fat-pad stem-cells for regenerating alveolar bone in aggressive-periodontitis patients. Data was obtained by literature study scientific research articles. In patients with AP, BFPSC can differentiate into osteoblast to improve osteogenesis, nHPA-CS scaffold creates host like tissue microenvironment to stimulate osteoinduction and osteoconduction activity of BFPSC, while PRF stimulates osteogenic differentiation and proliferation of BFPSC with insulin growth-factor, platelets derived growth-factor, transforming growth-factor, fibroblast growth-factor, vascular endothelial growth-factor. this combination increasing runt-related transcription-factor2, osterix, bone alkaline phosphatase, and controls pro-inflammatory cytokines such as interleukin-1beta (IL-1b) and tumor necrosis factor-alpha (TNF-a) so it can enhance bone regeneration and avoid bone destruction. The combination of nHPA-CS, PRF, BFPSC has the potential for alveolar bone regeneration in Aggressive-Periodontitis patients.


Cite this article:
Gustiadi Saputra, Alexander Patera Nugraha, Theresia Indah Budhy, Fransisca Shancti Rosari, Nur Aini Indah Lestari, Alifiya Afita Sari, Afiqah Gheasani, Theodora Valensia, Nastiti Faradilla Ramadhani, Tengku Natasha Eleena Binti Tengku Ahmad Noor, Albertus Putera Nugraha, Andreas Pratama Nugraha, Agung Sosiawan. Nanohydroxyapatite-Chitosan Hydrogel Scaffold with Platelet Rich Fibrin and Buccal Fat Pad derived Stem Cell for Aggressive Periodontitis Treatment: A Narrative Review. Research Journal of Pharmacy and Technology 2022; 15(12):5903-8. doi: 10.52711/0974-360X.2022.00995

Cite(Electronic):
Gustiadi Saputra, Alexander Patera Nugraha, Theresia Indah Budhy, Fransisca Shancti Rosari, Nur Aini Indah Lestari, Alifiya Afita Sari, Afiqah Gheasani, Theodora Valensia, Nastiti Faradilla Ramadhani, Tengku Natasha Eleena Binti Tengku Ahmad Noor, Albertus Putera Nugraha, Andreas Pratama Nugraha, Agung Sosiawan. Nanohydroxyapatite-Chitosan Hydrogel Scaffold with Platelet Rich Fibrin and Buccal Fat Pad derived Stem Cell for Aggressive Periodontitis Treatment: A Narrative Review. Research Journal of Pharmacy and Technology 2022; 15(12):5903-8. doi: 10.52711/0974-360X.2022.00995   Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-12-89


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