Author(s): Mohammed S. Hussein, Al-Moghira K. Al-Qaysi, Safaa Abed Latef Al Meani, Mohammed Mukhles Ahmed, Nihad Shahadha Abed, Mohammed Obaid Ibrahim

Email(s): moh.mukhles@uoanbar.edu.iq

DOI: 10.52711/0974-360X.2022.00965   

Address: Mohammed S. Hussein1, Al-Moghira K. Al-Qaysi2, Safaa Abed Latef Al Meani3, Mohammed Mukhles Ahmed4, Nihad Shahadha Abed5, Mohammed Obaid Ibrahim6
1Department of Biology, College of Science, University of Anbar, Anbar, Iraq.
2,3,4Department of Biotechnology, College of Science, University of Anbar, Anbar, Iraq
2Ministry of Health, Anbar health department, Iraq.
*Corresponding Author

Published In:   Volume - 15,      Issue - 12,     Year - 2022


ABSTRACT:
ABSTRACT: The emergence of resistant Klebsiella pneumoniae associated with COVID-19 demonstrate a primary challenge for the antimicrobial therapy of infectious diseases and increases the incidence of mortality and morbidity. "K. pneumoniae isolated from COVID-19 patient's sputum with ratio (100%). All K. pneumoniae clinical isolates had 100% resistance to ceftriaxone, piperacillin (80%), cefepime (60%), amikacin (40%), and meropenem =levofloxccin (20%). Bacterial isolates gave positive result for mCIM with ratio was 100%, also all isolates produced diversity of ? ß- lactamases at a rate of 100% by using spectrometry ß-lactamase assay. Costunolide (38.3 %), Rutin (15.33%), Pentadecanoic acid (6.54%), Oliec acid (4.77%), and Caproic acid (3.22%) considered as major compounds in Saussurea costus were identified by GC-Mass spectrometry. The ß-lactamase produced by K. pneumoniae were inhibited by Saussurea costus with a strong statistical significance at P- value: <0.01, while cinamic acid donot effected on ß-lactamase activity.


Cite this article:
Mohammed S. Hussein, Al-Moghira K. Al-Qaysi, Safaa Abed Latef Al Meani, Mohammed Mukhles Ahmed, Nihad Shahadha Abed, Mohammed Obaid Ibrahim. Assessment of Cinamic acid and Costus roots extract against MDR-K. pneumoniae isolated from patients of COVID-19. Research Journal of Pharmacy and Technology 2022; 15(12):5724-8. doi: 10.52711/0974-360X.2022.00965

Cite(Electronic):
Mohammed S. Hussein, Al-Moghira K. Al-Qaysi, Safaa Abed Latef Al Meani, Mohammed Mukhles Ahmed, Nihad Shahadha Abed, Mohammed Obaid Ibrahim. Assessment of Cinamic acid and Costus roots extract against MDR-K. pneumoniae isolated from patients of COVID-19. Research Journal of Pharmacy and Technology 2022; 15(12):5724-8. doi: 10.52711/0974-360X.2022.00965   Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-12-59


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