Author(s): Asep Sukohar, Fery Indradewi Armadany, Nuzul Aulia Fajarwati Bakede, Muhammad Hajrul Malaka, Dwi Aulia Ramdini, Andi Nafisah Tendri Adjeng

Email(s): andi.nafisah@fk.unila.ac.id

DOI: 10.52711/0974-360X.2022.00956   

Address: Asep Sukohar1, Fery Indradewi Armadany2, Nuzul Aulia Fajarwati Bakede2, Muhammad Hajrul Malaka2, Dwi Aulia Ramdini1, Andi Nafisah Tendri Adjeng1*
1Department of Pharmacy, Faculty of Medicine, Universitas Lampung, Bandar Lampung 35145, Lampung, Indonesia.
2Department of Pharmacy, Faculty of Pharmacy, Universitas Halu Oleo, Kendari, South-East Sulawesi, 93232, Indonesia.
*Corresponding Author

Published In:   Volume - 15,      Issue - 12,     Year - 2022


ABSTRACT:
Background: Candida albicans and Streptococcus mutans infection cases are increasingly common diseases giving bad impact on humans. High evidence of microbial included bacterial and fungal resistance because frequently used antibiotics contributes disability and death significantly worldwide. Hence, alternative and safe of antimicrobial agents are required. Clove leaves (Syzygium aromaticum L.) are part of the Myrtaceae family containing essential oils that are rich in eugenol as the main component having high antimicrobial activity. Therefore, this study focuses on evaluation of antimicrobial activity of clove leaf essential oil against Candida albicans and Streptococcus mutans. Methods: In the current study, the antibacterial efficiency of Syzygium aromaticum L. leaf essential oil against Candida albicans and Streptococcus mutans was determined by the disc diffusion method. Furthermore, the physical characterizations of essential oils that were carried out were colour, odour, solubility, density and total eugenol, respectively. Results: Clove leaf essential oil exhibited antimicrobial activity against pathogenic isolates Candida albicans was recorded at 0.5% having inhibition zones of 33.3±0.28 mm, 1% of 34±0.00mm, 1.5% of 35±0.28mm. While against gram-positive bacteria Streptococcus mutans at 0.5% presented an inhibition zone of 19.95±1.76mm, 1% of 20.5±2.12mm, 1.5% of 22.1±1.55mm. The physical characterization obtained from Clove leaf essential oil revealed that the essential oil presented yellow and distinctive odour, solubility in ethanol was 70% (1:2 clear), the density was 1.047g/ml, and eugenol total was 80%. Conclusion: This study indicates that essential oil of Syzygium aromaticum L leaves can be considered as potential antimicrobial agents.


Cite this article:
Asep Sukohar, Fery Indradewi Armadany, Nuzul Aulia Fajarwati Bakede, Muhammad Hajrul Malaka, Dwi Aulia Ramdini, Andi Nafisah Tendri Adjeng. Asep Sukohar, Fery Indradewi Armadany, Nuzul Aulia Fajarwati Bakede, Muhammad Hajrul Malaka, Dwi Aulia Ramdini, Andi Nafisah Tendri Adjeng. Antimicrobial Activity of Syzygium aromaticum L. Leaves Essential Oil against Candida albicans and Streptococcus mutans. Research Journal of Pharmacy and Technology 2022; 15(12):5672-6. doi: 10.52711/0974-360X.2022.00956

Cite(Electronic):
Asep Sukohar, Fery Indradewi Armadany, Nuzul Aulia Fajarwati Bakede, Muhammad Hajrul Malaka, Dwi Aulia Ramdini, Andi Nafisah Tendri Adjeng. Asep Sukohar, Fery Indradewi Armadany, Nuzul Aulia Fajarwati Bakede, Muhammad Hajrul Malaka, Dwi Aulia Ramdini, Andi Nafisah Tendri Adjeng. Antimicrobial Activity of Syzygium aromaticum L. Leaves Essential Oil against Candida albicans and Streptococcus mutans. Research Journal of Pharmacy and Technology 2022; 15(12):5672-6. doi: 10.52711/0974-360X.2022.00956   Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-12-50


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