Author(s): Nagesh Kishan Panchal, Jerine Peter S, Chandrayee Sil, Pratiksha Chhetri, Evan Prince Sabina

Email(s): eps674@gmail.com

DOI: 10.52711/0974-360X.2022.00951   

Address: Nagesh Kishan Panchal, Jerine Peter S, Chandrayee Sil, Pratiksha Chhetri, Evan Prince Sabina*
Department of Biomedical Sciences, School of Biosciences and Technology, Vellore Institute of Technology Vellore, India.
*Corresponding Author

Published In:   Volume - 15,      Issue - 12,     Year - 2022


ABSTRACT:
The epithelial to mesenchymal transition (EMT) has been associated with the invasion and migration of tumor cells, thus playing a fundamental role in cancer progression and metastasis. Breast cancer is a heterogeneous disease, which has been regarded as one of the leading causes of death amongst women globally. The initiation of EMT in breast cancer embraces the involvement of multiple signaling pathways. The involvement of a few factors present in EMT has left a prominent impact on shaping breast cancer development. Solanum surattense, belonging to the family Solanaceae, possesses numerous therapeutic properties due to the presence of several substances. In this study, we focused on major key players genes in promoting EMT, which increases the severity of cancer. Using GC/MS analysis, the active compounds from Solanum surattense were predicted. Molecular docking studies for this extracted active compounds were performed against the genes responsible for EMT using the PatchDock server. The docked complexes were then visualized using PyMOL. Results obtained from the molecular docking showed the inhibitory effect against the EMT pathway, thus inhibiting breast cancer progression.


Cite this article:
Nagesh Kishan Panchal, Jerine Peter S, Chandrayee Sil, Pratiksha Chhetri, Evan Prince Sabina. Targeting Epithelial to Mesenchymal Transition in Breast Cancer with Bioactive Compounds derived from Solanum surattense: A GC-MS and Molecular Docking approach. Research Journal of Pharmacy and Technology 2022; 15(12):5637-4. doi: 10.52711/0974-360X.2022.00951

Cite(Electronic):
Nagesh Kishan Panchal, Jerine Peter S, Chandrayee Sil, Pratiksha Chhetri, Evan Prince Sabina. Targeting Epithelial to Mesenchymal Transition in Breast Cancer with Bioactive Compounds derived from Solanum surattense: A GC-MS and Molecular Docking approach. Research Journal of Pharmacy and Technology 2022; 15(12):5637-4. doi: 10.52711/0974-360X.2022.00951   Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-12-45


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