Author(s): Maria Apriliani Gani, Ahmad Dzulfikri Nurhan, Fedik Abdul Rantam, Chrismawan Ardianto, Junaidi Khotib


DOI: 10.52711/0974-360X.2022.00948   

Address: Maria Apriliani Gani1, Ahmad Dzulfikri Nurhan2, Fedik Abdul Rantam3, Chrismawan Ardianto2, Junaidi Khotib2*
1Doctoral Programme of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Surabaya 60115, Indonesia.
2Department of Pharmacy Practice, Faculty of Pharmacy, Universitas Airlangga, Surabaya 60115, Indonesia.
3Laboratory of Virology and Immunology, Department of Microbiology, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya 60115, Indonesia.
*Corresponding Author

Published In:   Volume - 15,      Issue - 12,     Year - 2022

Osteoporosis is a systemic skeletal disease characterized by low bone mass, that can result in fracture when injury, for example, due to a traffic accident. This study aimed to identify secondary metabolites from Zingiber officinale that potentially inhibit cathepsin K, a critical enzyme that caused osteoporosis. In this study, a molecular docking of 102 bioactive compounds from Zingiber officinale against cathepsin K (PDB ID: 4X6I) was conducted. Ligand preparation was performed using JChem and Schrödinger’s software, and virtual protein was elucidated using AutoDockTools version 1.5.6. Cocrystal ligand was carried out as a positive control ligand. Pharmacokinetics of the compounds was predicted with SwissADME online tool. Based on the results, nine compounds had good binding affinity against cathepsin K. The compounds were shogasulfonic acid C, (-)-beta-sitosterol, shogasulfonic acid D, shogasulfonic acid B, shogasulfonic acid A, isogingerenone B, (S)-8-gingerol, gingerenone A, and hexahydrocurcumin, with binding affinities of -7.2, -7.0, -6.9, -6.8, -6.8, -6.7, -6.7, -6.6, and -6.4 kcal mol-1, respectively. Most compounds had great pharmacokinetic profiles and also drug-likeness properties. In conclusion, bioactive compounds from Zingiber officinale are potentially used as anti-osteoporosis agents targeting cathepsin K. However, in vitro and in vivo studies are needed to prove the anti-osteoporosis activity of these compounds.

Cite this article:
Maria Apriliani Gani, Ahmad Dzulfikri Nurhan, Fedik Abdul Rantam, Chrismawan Ardianto, Junaidi Khotib. Potential Anti-osteoporosis compounds from Zingiber officinale: A Molecular Docking and Pharmacokinetics Prediction. Research Journal of Pharmacy and Technology 2022; 15(12):5617-5. doi: 10.52711/0974-360X.2022.00948

Maria Apriliani Gani, Ahmad Dzulfikri Nurhan, Fedik Abdul Rantam, Chrismawan Ardianto, Junaidi Khotib. Potential Anti-osteoporosis compounds from Zingiber officinale: A Molecular Docking and Pharmacokinetics Prediction. Research Journal of Pharmacy and Technology 2022; 15(12):5617-5. doi: 10.52711/0974-360X.2022.00948   Available on:

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