Author(s): Rahul Jodh, Mukund Tawar, Aparna Kachewar

Email(s): jodhrahul@gmail.com

DOI: 10.52711/0974-360X.2022.00947   

Address: Rahul Jodh1*, Mukund Tawar2, Aparna Kachewar1
1Department of Pharmacology, P.R. Pote Patil College of Pharmacy, Amravati – 444604.
2Department of Pharmaceutics, P.R. Pote Patil College of Pharmacy, Amravati – 444604.
*Corresponding Author

Published In:   Volume - 15,      Issue - 12,     Year - 2022


ABSTRACT:
In the present experiment, Tricholepis glaberrima DC has been taken to study its antidepressant activity. The study was carried out in two different doses of the test drug. The animals were divided into 4 groups of 5 animals each, respectively. Mice in Group I (control) and II (standard) were administered distilled water, per oral and Imipramine 10mg/kg, per oral once respectively. Group III and IV were treated with the test drug METG in the dose of 100mg/kg and 300mg/kg, respectively. Findings of the test groups were compared with that of standard as well as plain control groups. In despair swim test and Tail suspension method, METG (100mg/kg and 300mg/kg per oral) depicted significant (*p<0.05 and p<0.01) results, in a dose dependent manner, when compared to vehicle treated group, indicating significant antidepressant activity. The results obtained in the present study for antioxidant activity indicate that the plants of Tricholepis glaberrima DC are a significant source of natural antioxidants. This test reveals the antidepressant activity of Tricholepis glaberrima DC Via serotonergic, adrenergic mechanism in a dose dependent pattern.


Cite this article:
Rahul Jodh, Mukund Tawar, Aparna Kachewar. Evaluation of Antidepressant activity of Tricholepis glaberrima DC using various Paradigms. Research Journal of Pharmacy and Technology 2022; 15(12):5610-6. doi: 10.52711/0974-360X.2022.00947

Cite(Electronic):
Rahul Jodh, Mukund Tawar, Aparna Kachewar. Evaluation of Antidepressant activity of Tricholepis glaberrima DC using various Paradigms. Research Journal of Pharmacy and Technology 2022; 15(12):5610-6. doi: 10.52711/0974-360X.2022.00947   Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-12-41


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