Author(s): Sanni Babu Najana, Hari Babu Bollikolla

Email(s): n.sannibabu@gmail.com , dr.b.haribabu@gmail.com

DOI: 10.52711/0974-360X.2022.00945   

Address: Sanni Babu Najana*, Hari Babu Bollikolla
Department of Chemistry, Acharya Nagarjuna University, Nagarjunanagar, Guntur, Andhra Pradesh, India.
*Corresponding Author

Published In:   Volume - 15,      Issue - 12,     Year - 2022


ABSTRACT:
Extremely responsive technique designed for the willpower of trometamol for instance tris(hydroxymethyl) aminomethane in gadobutrol by RP-LC technique. Quantification of trometamol content in gadobutrol samples by HPLC with refractive index detector (RID). Trometamol was UV inactive compound. Trometamol was determined by RP-LC method using Inertsil NH2 (250x4.6mm, 5µm) column as motionless segment. Column temperature maintained 30°C, inoculation quantity 10µL, flow velocity was 0.3 ml/min, sample cooler temperature 25°C. The mixture of phosphate buffer and cyanomethane in the ratio of 990:10 (volume/volume) was utilized as movable segment. The technique legalization erstwhile conceded as indicated by ICH guidelines.


Cite this article:
Sanni Babu Najana, Hari Babu Bollikolla. Estimation of Trometamol content in Gadobutrol solution for intravenous administration by using RP-LC with Refractive Index Detector. Research Journal of Pharmacy and Technology 2022; 15(12):5597-2. doi: 10.52711/0974-360X.2022.00945

Cite(Electronic):
Sanni Babu Najana, Hari Babu Bollikolla. Estimation of Trometamol content in Gadobutrol solution for intravenous administration by using RP-LC with Refractive Index Detector. Research Journal of Pharmacy and Technology 2022; 15(12):5597-2. doi: 10.52711/0974-360X.2022.00945   Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-12-39


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