Author(s): Sanjana Subramanian, Haripriya Thiruvengadamani, Mythili Sathiavelu


DOI: 10.52711/0974-360X.2022.00935   

Address: Sanjana Subramanian, Haripriya Thiruvengadamani, Mythili Sathiavelu
School of Biosciences and Technology, Vellore Institute of Technology, Tamil Nadu, India.
*Corresponding Author

Published In:   Volume - 15,      Issue - 12,     Year - 2022

The gastrointestinal tract of humans has trillions of bacteria, which are of vital importance to the proper functioning of the body. They are not only essential for the digestion and absorption of nutrients, but even play a part in the immune system and metabolism of humans. For instance, it has been observed that the microbiome of healthy individuals is significantly different from those of diseased individuals. Across all species, the commonly occurring bacterial phyla in the GI tract are Bacteroidetes, Firmicutes and Proteobacteria. However, the proportion of these phyla have great diversity across species. In this review, we examine the similarities and differences between human gut microbiota with those of other animals and also the reasons for gut microbiota diversity, observing factors such as age, diet, and disease. By analyzing and observing such variations, effective treatments for GI diseases can be developed, common evolutionary history between species can be ascertained and developing healthy gut microbial environments may be possible.

Cite this article:
Sanjana Subramanian, Haripriya Thiruvengadamani, Mythili Sathiavelu. Comparison of Human gut Microbiota with other Animals. Research Journal of Pharmacy and Technology 2022; 15(12):5541-7. doi: 10.52711/0974-360X.2022.00935

Sanjana Subramanian, Haripriya Thiruvengadamani, Mythili Sathiavelu. Comparison of Human gut Microbiota with other Animals. Research Journal of Pharmacy and Technology 2022; 15(12):5541-7. doi: 10.52711/0974-360X.2022.00935   Available on:

1.    Ahn J, Sinha R, Pei Z, Dominianni C, Wu J, Shi J, Goedert JJ, Hayes RB, Yang L. Human gut microbiome and risk for colorectal cancer. Journal of the National Cancer Institute. 2013; 105(24):1907-1911.
2.    Walter J, Ley R. The human gut microbiome: ecology and recent evolutionary changes. Annual review of microbiology. 2011; 65:411-429
3.    Bäckhed F, Roswall J, Peng Y, Feng Q, Jia H, Kovatcheva-Datchary P, Li Y, Xia Y, Xie H, Zhong H, Khan MT. Dynamics and stabilization of the human gut microbiome during the first year of life. Cell host & microbe. 2015; 17(5):690-703.
4.    Goodrich JK, Waters JL, Poole AC, Sutter JL, Koren O, Blekhman R, Beaumont M, Van Treuren W, Knight R, Bell JT, Spector TD. Human genetics shape the gut microbiome. Cell. 2014; 159(4):789-799.
5.    Ley RE, Lozupone CA, Hamady M, Knight R, Gordon JI. Worlds within worlds: evolution of the vertebrate gut microbiota. Nature Reviews Microbiology. 2008; 6(10):776-788.
6.    Koenig JE, Spor A, Scalfone N, Fricker AD, Stombaugh J, Knight R, Angenent LT, Ley RE. Succession of microbial consortia in the developing infant gut microbiome. Proceedings of the National Academy of Sciences. 2011; 108(Supplement 1):4578-4585.
7.    Kau AL, Ahern PP, Griffin NW, Goodman AL, Gordon JI. Human nutrition, the gut microbiome and the immune system. Nature. 2011; 474(7351):327-336.
8.    Yatsunenko T, Rey FE, Manary MJ, Trehan I, Dominguez-Bello MG, Contreras M, Magris M, Hidalgo G, Baldassano RN, Anokhin AP, Heath AC. Human gut microbiome viewed across age and geography. Nature. 2012; 486(7402):222-227.
9.    David LA, Maurice CF, Carmody RN, Gootenberg DB, Button JE, Wolfe BE, Ling AV, Devlin AS, Varma Y, Fischbach MA, Biddinger SB. Diet rapidly and reproducibly alters the human gut microbiome. Nature. 2014; 505(7484):559-563.
10.    Moeller AH, Degnan PH, Pusey AE, Wilson ML, Hahn BH, Ochman H. Chimpanzees and humans harbour compositionally similar gut enterotypes. Nature communications. 2012; 3(1):1-5.
11.    Singh RK, Chang HW, Yan DI, Lee KM, Ucmak D, Wong K, Abrouk M, Farahnik B, Nakamura M, Zhu TH, Bhutani T. Influence of diet on the gut microbiome and implications for human health. Journal of translational medicine. 2017; 15(1):1-7.
12.    Bäckhed F, Fraser CM, Ringel Y, Sanders ME, Sartor RB, Sherman PM, Versalovic J, Young V, Finlay BB. Defining a healthy human gut microbiome: current concepts, future directions, and clinical applications. Cell host and microbe. 2012; 12(5):611-622.
13.    Jangi S, Gandhi R, Cox LM, Li N, Von Glehn F, Yan R, Patel B, Mazzola MA, Liu S, Glanz BL, Cook S. Alterations of the human gut microbiome in multiple sclerosis. Nature communications. 2016; 7(1):1-1.
14.    Nishida AH, Ochman H. Rates of gut microbiome divergence in mammals. Molecular ecology. 2018 (8):1884-1897.
15.    McKenzie VJ, Song SJ, Delsuc F, Prest TL, Oliverio AM, Korpita TM, Alexiev A, Amato KR, Metcalf JL, Kowalewski M, Avenant NL. The effects of captivity on the mammalian gut microbiome. Integrative and comparative biology. 2017; 57(4):690-704.
16.    Yasuda K, Oh K, Ren B, Tickle TL, Franzosa EA, Wachtman LM, Miller AD, Westmoreland SV, Mansfield KG, Vallender EJ, Miller GM. Biogeography of the intestinal mucosal and lumenal microbiome in the rhesus macaque. Cell host & microbe. 2015; 17(3):385-391.
17.    McKenna P, Hoffmann C, Minkah N, Aye PP, Lackner A, Liu Z, Lozupone CA, Hamady M, Knight R, Bushman FD. The macaque gut microbiome in health, lentiviral infection, and chronic enterocolitis. PLoSPathog. 2008; 4(2):e20.
18.    Suchodolski JS. Microbes and gastrointestinal health of dogs and cats. In JOURNAL OF DAIRY SCIENCE 2010 (Vol. 93, pp. 263-263).
19.    Tun HM, Brar MS, Khin N, Jun L, Hui RK, Dowd SE, Leung FC. Gene-centric metagenomics analysis of feline intestinal microbiome using 454 junior pyrosequencing. Journal of microbiological methods. 2012; 88(3):369-376.
20.    Coelho LP, Kultima JR, Costea PI, Fournier C, Pan Y, Czarnecki-Maulden G, Hayward MR, Forslund SK, Schmidt TS, Descombes P, Jackson JR. Similarity of the dog and human gut microbiomes in gene content and response to diet. Microbiome. 2018; 6(1):1-1.
21.    Maurice CF, Knowles SC, Ladau J, Pollard KS, Fenton A, Pedersen AB, Turnbaugh PJ. Marked seasonal variation in the wild mouse gut microbiota. The ISME journal. 2015; 9(11):2423-2434.
22.    Petri RM, Schwaiger T, Penner GB, Beauchemin KA, Forster RJ, McKinnon JJ, McAllister TA. Characterization of the core rumen microbiome in cattle during transition from forage to concentrate as well as during and after an acidotic challenge. PloS one. 2013; 8(12): e83424.
23.    Malmuthuge N, Griebel PJ, Guan LL. The gut microbiome and its potential role in the development and function of newborn calf gastrointestinal tract. Frontiers in veterinary science. 2015; 2:36.
24.    Costa MC, Silva G, Ramos RV, Staempfli HR, Arroyo LG, Kim P, Weese JS. Characterization and comparison of the bacterial microbiota in different gastrointestinal tract compartments in horses. The Veterinary Journal. 2015; 205(1):74-80.
25.    Dougal K, Harris PA, Edwards A, Pachebat JA, Blackmore TM, Worgan HJ, Newbold CJ. A comparison of the microbiome and the metabolome of different regions of the equine hindgut. FEMS microbiology ecology. 2012; 82(3):642-652.
26.    Egerton S, Culloty S, Whooley J, Stanton C, Ross RP. The gut microbiota of marine fish. Frontiers in microbiology. 2018; 9:873.
27.    Talwar C, Nagar S, Lal R, Negi RK. Fish gut microbiome: current approaches and future perspectives. Indian journal of microbiology. 2018; 58(4):397-414.
28.    Colston TJ, Jackson CR. Microbiome evolution along divergent branches of the vertebrate tree of life: what is known and unknown. Molecular ecology. 2016; 25(16):3776-3800.
29.    Liu H, Guo X, Gooneratne R, Lai R, Zeng C, Zhan F, Wang W. The gut microbiome and degradation enzyme activity of wild freshwater fishes influenced by their trophic levels. Scientific reports. 2016; 6(1):1-2.
30.    Xia JH, Lin G, Fu GH, Wan ZY, Lee M, Wang L, Liu XJ, Yue GH. The intestinal microbiome of fish under starvation. BMC genomics. 2014; 15(1):1-1.
31.    Jiménez RR, Alvarado G, Estrella J, Sommer S. Moving beyond the host: unraveling the skin microbiome of endangered Costa Rican amphibians. Frontiers in microbiology. 2019; 10:2060.
32.    Kohl KD, Cary TL, Karasov WH, Dearing MD. Restructuring of the amphibian gut microbiota through metamorphosis. Environmental Microbiology Reports. 2013; 5(6):899-903.
33.    Kohl KD, Yahn J. Effects of environmental temperature on the gut microbial communities of tadpoles. Environmental Microbiology. 2016; 18(5):1561-1565.
34.    Colston TJ, Noonan BP, Jackson CR. Phylogenetic analysis of bacterial communities in different regions of the gastrointestinal tract of Agkistrodonpiscivorus, the cottonmouth snake. PLoS One. 2015; 10(6):e0128793.
35.    Costello EK, Gordon JI, Secor SM, Knight R. Postprandial remodeling of the gut microbiota in Burmese pythons. The ISME journal. 2010; 4(11):1375-1385.
36.    Hird SM, Sánchez C, Carstens BC, Brumfield RT. Comparative gut microbiota of 59 neotropical bird species. Frontiers in microbiology. 2015; 6:1403.
37.    Waite DW, Taylor M. Exploring the avian gut microbiota: current trends and future directions. Frontiers in microbiology. 2015; 6:673.
38.    Beasley DE, Koltz AM, Lambert JE, Fierer N, Dunn RR. The evolution of stomach acidity and its relevance to the human microbiome. PloS one. 2015; 10(7):e0134116.
39.    Videvall E, Strandh M, Engelbrecht A, Cloete S, Cornwallis CK. Measuring the gut microbiome in birds: comparison of faecal and cloacal sampling. Molecular ecology resources. 2018; 18(3):424-434.
40.    Grond K, Santo Domingo JW, Lanctot RB, Jumpponen A, Bentzen RL, Boldenow ML, Brown SC, Casler B, Cunningham JA, Doll AC, Freeman S. Composition and drivers of gut microbial communities in Arctic-breeding shorebirds. Frontiers in microbiology. 2019; 10:2258.
41.    Oakley BB, Lillehoj HS, Kogut MH, Kim WK, Maurer JJ, Pedroso A, Lee MD, Collett SR, Johnson TJ, Cox NA. The chicken gastrointestinal microbiome. FEMS microbiology letters. 2014; 360(2):100-112.
42.    Pourabedin M, Zhao X. Prebiotics and gut microbiota in chickens. FEMS microbiology letters. 2015; 362(15):fnv122.
43.    Wei S, Morrison M, Yu Z. Bacterial census of poultry intestinal microbiome. Poultry science. 2013; 92(3):671-683.
44.    Yun JH, Roh SW, Whon TW, Jung MJ, Kim MS, Park DS, Yoon C, Nam YD, Kim YJ, Choi JH, Kim JY. Insect gut bacterial diversity determined by environmental habitat, diet, developmental stage, and phylogeny of host. Applied and Environmental Microbiology. 2014; 80(17):5254-5264.
45.    Dillon RJ, Dillon VM. The gut bacteria of insects: nonpathogenic interactions. Annual Reviews in Entomology. 2004; 49(1):71-92.
46.    Hammer TJ, Janzen DH, Hallwachs W, Jaffe SP, Fierer N. Caterpillars lack a resident gut microbiome. Proceedings of the National Academy of Sciences. 2017; 114(36):9641-9646.
47.    Kwong WK, Moran NA. Gut microbial communities of social bees. Nature reviews microbiology. 2016; 14(6):374-384.
48.    Cardoso AM, Cavalcante JJ, Vieira RP, Lima JL, Grieco MA, Clementino MM, Vasconcelo AT, Garcia ES, de Souza W, Albano RM, Martins OB. Gut bacterial communities in the giant land snail Achatinafulica and their modification by sugarcane-based diet. PloS one. 2012; 7(3):e33440.
49.    Clark LC, Hodgkin J. Caenorhabditis microbiota: worm guts get populated. BMC biology. 2016; 14(1):1-3.
50.    Dirksen P, Marsh SA, Braker I, Heitland N, Wagner S, Nakad R, Mader S, Petersen C, Kowallik V, Rosenstiel P, Félix MA. The native microbiome of the nematode Caenorhabditiselegans: gateway to a new host-microbiome model. BMC biology. 2016; 14(1):1-6.

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