Author(s): N. Vishal Prakasam, Gayatri Devi. R, J. Selvaraj, A. Jothi Priya


DOI: 10.52711/0974-360X.2022.00920   

Address: N. Vishal Prakasam1, Gayatri Devi. R2, J. Selvaraj3, A. Jothi Priya4
1Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Science (SIMATS) Saveetha University, Chennai – 600077.
2Associate Professor, Department of Physiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Science (SIMATS), Saveetha University, Chennai – 600077.
3Associate Professor, Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Science (SIMATS), Saveetha University, Chennai – 600077.
4Assistant Professor, Department of Physiology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Science (SIMATS), Saveetha University, Chennai – 600077.
*Corresponding Author

Published In:   Volume - 15,      Issue - 12,     Year - 2022

Background: Mimosa pudica commonly known as the “Touch me not” originated from the family “mimosaceae”. Mimosa pudica possesses a lot of medicinal values such as anti-bacterial, anti-fungal, anti-diabetic properties etc. Euphorbia hirta is commonly known for curing patients suffering from asthma hence the name “Asthma plant”. It has various medicinal properties such as anti-fungal,anti-bacterial,anti-diabetic etc. Both these plants has anti-diabetic property hence the present was done to compare which medicinal herb is a better replacement for the standard synthetic drug “Metformin”. Materials and Methods: Assessment of in vitro anti-diabetic activity of Mimosa pudica and Euphorbia hirta was performed by alpha-amylase inhibitory activity and alpha-glucosidase inhibitory activity. The result was compared to the standard drug metformin. The data were analysed statistically using one way analysis of variance (ONE-WAY ANOVA). Duncan Multiple range test was used to analyze the statistical significance between groups. The levels of significance were considered at the levels of p<0.05. Result: Both the plants showed an increase in percentage on inhibition of alpha amylase and alpha glucosidase in dose dependent manner. Conclusion: In the present study, it was revealed that the medicinal plant Euphorbia hirta showed a better antidiabetic activity than Mimosa pudica.

Cite this article:
N. Vishal Prakasam, Gayatri Devi. R, J. Selvaraj, A. Jothi Priya. In-vitro Antidiabetic on leaf extracts of Mimosa pudica and Euphorbia hirta - A Comparative Study. Research Journal of Pharmacy and Technology2022; 15(12):5459-3. doi: 10.52711/0974-360X.2022.00920

N. Vishal Prakasam, Gayatri Devi. R, J. Selvaraj, A. Jothi Priya. In-vitro Antidiabetic on leaf extracts of Mimosa pudica and Euphorbia hirta - A Comparative Study. Research Journal of Pharmacy and Technology2022; 15(12):5459-3. doi: 10.52711/0974-360X.2022.00920   Available on:

1.    Oguntibeju O. Antioxidant-Antidiabetic Agents and Human Health. BoD – Books on Demand; 2014.
2.    Funke I, Melzig MF. Traditionally used plants in diabetes therapy: phytotherapeutics as inhibitors of alpha-amylase activity. Revista Brasileira de Farmacognosia. 2006;16(1):1-5. doi:10.1590/s0102-695x2006000100002
3.    Kale MPM. A Review Article on Euphorbia hirta uses and pharmacological activities. Asian J Res Pharm Sci. 2016; 6(3):141.
4.    Eslavath R, Anasuri S, Rajeshwari E. Mimosa pudica-an Important Medicinal Plant: A Review of Its Folklore Medicine and Traditional Uses. Asian Journal of Research in Pharmaceutical Sciences. 2014;4(3): 151-152.
5.    Josewin B, Ramachandrapai M, Suseelan MS. ChemInform Abstract: A New Phenolic Ketone from the Leaves of Mimosa pudica Linn. ChemInform. 2010;30(31):no - no. doi:10.1002/chin.199931268
6.    Ueda M, Yamamura S. Leaf-opening substance of Mimosa pudica L.; chemical studies on the other leaf movement of mimosa. Tetrahedron Letters. 1999;40(2):353-356. doi:10.1016/s0040-4039(98)02349-1
7.    Nair PV, Nair BLR. Anti-inflammatory activity of hydroalcoholic extract of mimosa pudica whole plant in rats. International Journal of Basic and Clinical Pharmacology. 2017;6(3):518. doi:10.18203/2319-2003.ijbcp20170473
8.    Kumar RS, Santosh Kumar R, Rajkiran K, Patnaik SK. Evaluation of Incisional Diabetic Wound Healing Activity of Ethanolic Leave Extract of Mimosa pudica L. in Rats. International Journal of Pharmacognosy and Phytochemical Research. 2017;9(08). doi:10.25258/phyto.v9i08.9623
9.    T S, Sheela T, T PP, Balla S. Green Synthesis and Characterization of Silver Nanoparticles Using Mimosa pudica Leaves for Anti-diabetic Activity. International Journal of Pharmaceutical Sciences Review and Research. 2020;65(1):187-193. doi:10.47583/ijpsrr.2020.v65i01.028
10.    Rajendran R, Hemachander R, Ezhilarasan T, et al. Phytochemical Analysis and In-Vitro Antioxidant Activity of Mimosa pudica Lin., Leaves. Research Journal of Pharmacy and Technology. 2010;3(2): 551-555.
11.    Sathish Kumar S, Melchias G, Ravikumar P, Chandrasekar R, Kumaravel P. Bioinspired synthesis of silver nanoparticles using Euphorbia hirta leaf extracts and their antibacterial activity. Asian Journal of Pharmaceutical Research. 2014;4(1): 39-43.
12.    Saraswathi I, Saikarthik J, Senthil Kumar K, Madhan Srinivasan K, Ardhanaari M, Gunapriya R. Impact of COVID-19 outbreak on the mental health status of undergraduate medical students in a COVID-19 treating medical college: a prospective longitudinal study. Peer J. 2020; 8:e10164.
13.    Santhakumar P, Roy A, Mohanraj KG, Jayaraman S, Durairaj R. Ethanolic Extract of Capparis decidua Fruit Ameliorates Methotrexate-Induced Hepatotoxicity by Activating Nrf2/HO-1 and PPARγ Mediated Pathways. Ind J Pharm Educ. 2021;55(1s):s265-s274.
14.    Nambi G, Kamal W, Es S, Joshi S, Trivedi P. Spinal manipulation plus laser therapy versus laser therapy alone in the treatment of chronic non-specific low back pain: a randomized controlled study. Eur J Phys Rehabil Med. 2018;54(6): 880-889.
15.    Rajakumari R, Volova T, Oluwafemi OS, Rajesh Kumar S, Thomas S, Kalarikkal N. Grape seed extract-soluplus dispersion and its antioxidant activity. Drug Dev Ind Pharm. 2020;46(8): 1219-1229.
16.    Clarizia G, Bernardo P. Diverse Applications of Organic-Inorganic Nanocomposites: Emerging Research and Opportunities: Emerging Research and Opportunities. IGI Global; 2019.
17.    Prakash AKS, Devaraj E. Cytotoxic potentials of S. cumini methanolic seed kernel extract in human hepatoma HepG2 cells. Environmental Toxicology. 2019;34(12):1313-1319. doi:10.1002/tox.22832
18.    Tahmasebi S, Qasim MT, Krivenkova MV, et al. The effects of oxygen-ozone therapy on regulatory T-cell responses in multiple sclerosis patients. Cell Biol Int. 2021;45(7):1498-1509.
19.    Wadhwa R, Paudel KR, Chin LH, et al. Anti-inflammatory and anticancer activities of Naringenin-loaded liquid crystalline nanoparticles in vitro. J Food Biochem. 2021;45(1):e13572.
20.    Vivekanandhan K, Shanmugam P, Barabadi H, et al. Emerging Therapeutic Approaches to Combat COVID-19: Present Status and Future Perspectives. Frontiers in Molecular Biosciences. 2021;8. doi:10.3389/fmolb.2021.604447
21.    Ezhilarasan D. Critical role of estrogen in the progression of chronic liver diseases. Hepatobiliary Pancreat Dis Int. 2020;19(5):429-434.
22.    Egbuna C, Mishra AP, Goyal MR. Preparation of Phytopharmaceuticals for the Management of Disorders: The Development of Nutraceuticals and Traditional Medicine. Academic Press; 2020.
23.    Kamath SM, Manjunath Kamath S, Jaison D, et al. In vitro augmentation of chondrogenesis by Epigallocatechin gallate in primary Human chondrocytes - Sustained release model for cartilage regeneration. Journal of Drug Delivery Science and Technology. 2020;60:101992. doi:10.1016/j.jddst.2020.101992
24.    Sridharan G, Ramani P, Patankar S, Vijayaraghavan R. Evaluation of salivary metabolomics in oral leukoplakia and oral squamous cell carcinoma. J Oral Pathol Med. 2019;48(4): 299-306.
25.    R H, Hannah R, Ramani P, et al. CYP2 C9 polymorphism among patients with oral squamous cell carcinoma and its role in altering the metabolism of benzo[a]pyrene. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 2020;130(3):306-312. doi:10.1016/j.oooo.2020.06.021
26.    J PC, Pradeep CJ, Marimuthu T, Krithika C, Devadoss P, Kumar SM. Prevalence and measurement of anterior loop of the mandibular canal using CBCT: A cross sectional study. Clinical Implant Dentistry and Related Research. 2018;20(4):531-534. doi:10.1111/cid.12609
27.    Wahab PUA, Abdul Wahab PU, Madhulaxmi M, et al. Scalpel Versus Diathermy in Wound Healing After Mucosal Incisions: A Split-Mouth Study. Journal of Oral and Maxillofacial Surgery. 2018;76(6):1160-1164. doi:10.1016/j.joms.2017.12.020
28.    Mudigonda SK, Murugan S, Velavan K, Thulasiraman S, Krishna Kumar Raja VB. Non-suturing microvascular anastomosis in maxillofacial reconstruction- a comparative study. Journal of Cranio-Maxillofacial Surgery. 2020;48(6): 599-606.
29.    Teeli RA, Ganie SA, Dar MS, Raja W, Yadav SS. Antioxidant activity of Euphorbia hirta L. leaf extracts. J Adv Pharm Technol Res. 2018;11(1):199.
30.    Anjitha R, Subbaraya U, Narasimhan G. Integrated Invitro-Insilico screening strategy of Ethanolic extract of leaves of Passiflora edulis Sims var. flavicarpa against Alpha Glucosidase. J Adv Pharm Technol Res. 2020; 13(3):1309.
31.    Moradi B, Abbaszadeh S, Shahsavari S, Alizadeh M, Beyranvand F. The most useful medicinal herbs to treat diabetes. Biomedical Research and Therapy. 2018;5(8):2538-2551. doi:10.15419/bmrat.v5i8.463
32.    Ali H, Houghton PJ, Soumyanath A. α-Amylase inhibitory activity of some Malaysian plants used to treat diabetes; with particular reference to Phyllanthus amarus. Journal of Ethnopharmacology. 2006;107(3):449-455. doi:10.1016/j.jep.2006.04.004
33.    Meher B, Satapathy T, . Sahu AK, Ahirwar KK, Kashinath PD, Jain NP. Screening of Methanolic Extract of Euphorbia hirta linn for Antiinflammatory Activity in Experimental Animals. Research Journal of Pharmacy and Technology. 2012;5(1): 38-40.
34.    Alssema M, Ruijgrok C, Blaak EE, et al. Effects of alpha-glucosidase-inhibiting drugs on acute postprandial glucose and insulin responses: a systematic review and meta-analysis. Nutr Diabetes. 2021; 11(1):11.
35.    Sajid M, Goswami R, Kumar JN. In vitro Alpha glucosidase and Aldolase reductase Inhibitory activity of Holoptelea integrifolia. Res j pharmacol pharmacodyn. May 2021: 35-40.
36.    Tunna TS, Zaidul ISM, Ahmed QU, et al. Analyses and profiling of extract and fractions of neglected weed Mimosa pudica Linn. traditionally used in Southeast Asia to treat diabetes. South African Journal of Botany. 2015;99:144-152. doi:10.1016/j.sajb.2015.02.016
37.    Jose BE, Panneerselvam P. In Vitro Antidiabetic activity of Ethanol and Aqueous leaf extracts of Azima tetracantha Lam. Res J Sci Technol. 2019;11(1): 64.
38.    Tasnuva ST, Qamar UA, Ghafoor K, et al. α-glucosidase inhibitors isolated from Mimosa pudica L. Natural Product Research. 2019;33(10):1495-1499. doi:10.1080/14786419.2017.1419224
39.    Neela FA, Khan MSI, Islam MS, Alam MF, Akter A. Screening of ethanol, petroleum ether and chloroform extracts of medicinal plants, Lawsonia inermis L. and Mimosa pudica L. for antibacterial activity. Indian Journal of Pharmaceutical Sciences. 2010;72(3):388. doi:10.4103/0250-474x.70492
40.    Rajalakshmi K, Banu N. Evaluation of antibacterial activity of sodium copper chlorophyll in from mimosa pudica L. J Adv Pharm Technol Res. 2017;10(2): 487.
41.    Sharma M, Sheliya M, Begum R, et al. In vitro α-glucosidase and α-amylase inhibition by aqueous, hydroalcoholic, and alcoholic extract of Euphorbia hirta L. Drug Development and Therapeutics. 2016;7(1):26. doi:10.4103/2394-6555.180156
42.    Sheliya MA, Rayhana B, Ali A, et al. Inhibition of α-glucosidase by new prenylated flavonoids from euphorbia hirta L. herb. Journal of Ethnopharmacology. 2015;176:1-8. doi:10.1016/j.jep.2015.10.018
43.    Bakar FIA, Bakar MFA, Abdullah N, Endrini S, Fatmawati S. Optimization of Extraction Conditions of Phytochemical Compounds and Anti-Gout Activity of Euphorbia hirta L. (Ara Tanah) Using Response Surface Methodology and Liquid Chromatography-Mass Spectrometry (LC-MS) Analysis. Evidence-Based Complementary and Alternative Medicine. 2020;2020:1-13. doi:10.1155/2020/4501261

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