Author(s):
Abhishek Bharti, Payal Mittal, Kundan Singh Bora
Email(s):
payal.talk2@gmail.com
DOI:
10.52711/0974-360X.2022.00897 
Address:
Abhishek Bharti, Payal Mittal*, Kundan Singh Bora
University Institute of Pharma Sciences, Chandigarh University, Gharuan, Mohali- 140413, India.
*Corresponding Author
Published In:
Volume - 15,
Issue - 11,
Year - 2022
ABSTRACT:
Neurotrophic elements are the development factors which are engaged with the neuronal endurance and recovery of neurons. It is finished by forestalling the customized cell passing apoptosis. Development factors are the gathering of proteins which invigorate the development of explicit tissues. They are communicated in different organic entities including people. These developmental factors do a significant job by controlling assortment of cell cycles like expansion, separation and development. This survey will examine about apoptosis and the different Neurotrophic components which are associated with neuronal endurance and recovery of neurones including GDNF, Neuropoietic cytokines, nerve development factors, cerebrum inferred neurotrophic factors (BDNF) and job of BDNF in antiapoptotic and cell endurance.
Cite this article:
Abhishek Bharti, Payal Mittal, Kundan Singh Bora. Neurotrophic Factors as Antiapoptotic Agents – A Review. Research Journal of Pharmacy and Technology. 2022; 15(11):5327-0. doi: 10.52711/0974-360X.2022.00897
Cite(Electronic):
Abhishek Bharti, Payal Mittal, Kundan Singh Bora. Neurotrophic Factors as Antiapoptotic Agents – A Review. Research Journal of Pharmacy and Technology. 2022; 15(11):5327-0. doi: 10.52711/0974-360X.2022.00897 Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-11-82
REFERENCES:
1. Davies AM. The role of neurotrophins in the developing nervous system. J Neurobiol. 1994; 25(11):1334-1348. doi:10.1002/neu.480251103
2. Hardy K, Spanos S. Growth factor expression and function in the human and mouse preimplantation embryo. J Endocrinol. 2002; 172(2):221-236. doi:10.1677/joe.0.1720221
3. Razavi S, Nazem G, Mardani M, Esfandiari E, Esfahani S, Salehi H. Neurotrophic factors and their effects in the treatment of multiple sclerosis. Adv Biomed Res. 2015; 4(1):53. doi:10.4103/2277-9175.151570
4. Trump BE, Berezesky IK, Seung H, Phelps PC. Pathways Oncosis, Apoptosis, and Necrosis. Toxicol Pathol. 1997; 25(1):82-88.
5. Nijhawan D, Honarpour N, Wang X. Apoptosis in neural development and disease. Annu Rev Neurosci. 2000; 23(July):73-87. doi:10.1146/annurev.neuro.23.1.73
6. Kerschensteiner M, Stadelmann C, Dechant G, Wekerle H, Hohlfeld R. Neurotrophic cross-talk between the nervous and immune systems: Implications for neurological diseases. Ann Neurol. 2003; 53(3):292-304. doi:10.1002/ana.10446
7. Chen S Der, Wu CL, Hwang WC, Yang DI. More insight into BDNF against neurodegeneration: Anti-apoptosis, anti-oxidation, and suppression of autophagy. Int J Mol Sci. 2017; 18(3):1-12. doi:10.3390/ijms18030545
8. Heese K, Jin WL, Inoue N. Nerve growth factor, neural stem cells and Alzheimer’s disease. NeuroSignals. 2006; 15(1):1-12. doi:10.1159/000094383
9. Torres N, Molet J, Moro C, Mitrofanis J, Benabid AL. Neuroprotective surgical strategies in Parkinson’s disease: Role of preclinical data. Int J Mol Sci. 2017;18(10). doi:10.3390/ijms18102190
10. Rosser A, Svendsen CN. Stem cells for cell replacement therapy: A therapeutic strategy for HD? Mov Disord. 2014; 29(11):1446-1454. doi:10.1002/mds.26026
11. Airaksinen MS, Saarma M. The GDNF family: Signalling, biological functions and therapeutic value. Nat Rev Neurosci. 2002; 3(5):383-394. doi:10.1038/nrn812
12. Levi‐Montalcini R, Hamburger V. Selective growth stimulating effects of mouse sarcoma on the sensory and sympathetic nervous system of the chick embryo. J Exp Zool. 1951; 116(2):321-361. doi:10.1002/jez.1401160206
13. Tenenbaum L, Humbert-Claude M. Glial cell line-derived neurotrophic factor gene delivery in parkinson’s disease: A delicate balance between neuroprotection, trophic effects, and unwanted compensatory mechanisms. Front Neuroanat. 2017;11(April):1-12. doi:10.3389/fnana.2017.00029
14. Ramer MS, Priestley J V., McMahon SB. Functional regeneration of sensory axons into the adult spinal cord. Nature. 2000; 403(6767):312-316. doi:10.1038/35002084
15. Horger BA, Nishimura MC, Armanini MP, et al. Neurturin exerts potent actions on survival and function of midbrain dopaminergic neurons. J Neurosci. 1998; 18(13):4929-4937. doi:10.1523/jneurosci.18-13-04929.1998
16. Davis S, Yancopoulos GD. The molecular biology of the CNTF receptor. Curr Opin Cell Biol. 1993; 5(2):281-285. doi:10.1016/0955-0674(93)90117-9
17. Brenneman DE, Gozes I. A femtomolar-acting neuroprotective peptide. J Clin Invest. 1996;97(10):2299-2307. doi:10.1172/JCI118672
18. Niwa H, Burdon T, Chambers I, Smith A. Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3. Genes Dev. 1998;12(13):2048-2060. doi:10.1101/gad.12.13.2048
19. Shelton DL, Reichardt LF. Studies on the expression of the β nerve growth factor (NGF) gene in the central nervous system: Level and regional distribution of NGF mRNA suggest that NGF functions as a trophic factor for several distinct populations of neurons. Proc Natl Acad Sci U S A. 1986; 83(8):2714-2718. doi:10.1073/pnas.83.8.2714
20. Walker F, Kato A, Gonez LJ, et al. Activation of the Ras/Mitogen-Activated Protein Kinase Pathway by Kinase-Defective Epidermal Growth Factor Receptors Results in Cell Survival but Not Proliferation. Mol Cell Biol. 1998; 18(12):7192-7204. doi:10.1128/mcb.18.12.7192
21. Nguyen N, Lee SB, Lee YS, Lee KH, Ahn JY. Erratum: Neuroprotection by NGF and BDNF against neurotoxin-exerted apoptotic death in neural stem cells are mediated through Trk receptors, activating PI3-kinase and MAPK pathways (Neurochemical Research DOI: 10.1007/s11064-008-9848-9). Neurochem Res. 2009; 34(5):952. doi:10.1007/s11064-008-9875-6
22. Lu J, Frerich JM, Turtzo LC, et al. Histone deacetylase inhibitors are neuroprotective and preserve NGF-mediated cell survival following traumatic brain injury. Proc Natl Acad Sci U S A. 2013; 110(26):10747-10752. doi:10.1073/pnas.1308950110
23. Ip NY, Ibanez CF, Nye SH, et al. Mammalian neurotrophin-4: Structure, chromosomal localization, tissue distribution, and receptor specificity. Proc Natl Acad Sci U S A. 1992;89(7):3060-3064. doi:10.1073/pnas.89.7.3060
24. Maisonpierre PC, Belluscio L, Squinto S, et al. Neurotrophin-3 : A Neurotrophic Factor Related to NGF dan BDNF. Science (80-). 1990; 247(10):1446-1451.
25. Klein R, Nanduri V, Jing S, et al. The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3. Cell. 1991; 66(2):395-403. doi:10.1016/0092-8674(91)90628-C
26. Leibrock J, Lottspeich F, Hohn A, et al. Molecular cloning and expression of brain-derived neurotrophic factor. Nature. 1989; 341(6238):149-152. doi:10.1038/341149a0
27. Bathina S, Das UN. Brain-derived neurotrophic factor and its clinical Implications. Arch Med Sci. 2015;11(6):1164-1178. doi:10.5114/aoms.2015.56342
28. Bamberger AM, Thuneke I, Schulte HM. Differential regulation of the human “leukemia inhibitory factor” (LIF) promoter in T47D and MDA-MB 231 breast cancer cells. Breast Cancer Res Treat. 1998; 47(2):153-161. doi:10.1023/A:1005961403898
29. Papers JBC, Doi M, Fang H, et al. Transcriptional Activation of the Human Brain-derived Neurotrophic Factor Gene Promoter III by Dopamine Signaling in NT2 / N Neurons. J Biol Chem. 2003; 278(29):26401-26409. doi:10.1074/jbc.M211539200
30. Donovan MJ, Miranda RC, Kraemer R, et al. Neurotrophin and neurotrophin receptors in vascular smooth muscle cells: Regulation of expression in response to injury. Am J Pathol. 1995; 147(2):309-324.
31. Bernd P. The role of neurotrophins during early development. Gene Expr. 2008;14(4):241-250. doi:10.3727/105221608786883799
32. Kaplan DR, Miller FD. Neurotrophin signal transduction in the nervous system. Curr Opin Neurobiol. 2000; 10(3):381-391. doi:10.1016/S0959-4388(00)00092-1
33. Sue Goo Rhee, Yun Soo Bae. Regulation of phosphoinositide-specific phospholipase C isozymes. J Biol Chem. 1997; 272(24):15045-15048. doi:10.1074/jbc.272.24.15045
34. Vaillant AR, Mazzoni I, Tudan C, Boudreau M, Kaplan DR, Miller FD. 3-Kinase – Akt Pathway to Synergistically Regulate Neuronal Survival. 1999; 146(5):955-966.
35. Corbit KC, Foster DA, Rosner MR. Protein Kinase Cδ Mediates Neurogenic but Not Mitogenic Activation of Mitogen-Activated Protein Kinase in Neuronal Cells. Mol Cell Biol. 1999; 19(6):4209-4218. doi:10.1128/mcb.19.6.4209