Author(s): Ravindra Bhimraj Laware, Santosh Bhausaheb Dighe, Braj Nandan Kishor

Email(s): ravilawre@rediffmail.com

DOI: 10.52711/0974-360X.2022.00894   

Address: Ravindra Bhimraj Laware1*, Santosh Bhausaheb Dighe2, Braj Nandan Kishor3
1College of Pharmacy, Pravara Institute of Medical Sciences, Loni, Tal- Rahata, Dist- Ahmednagar, M.S.
2Department of Pharmacology, Pravara Rural College of Pharmacy, Loni, Tal- Rahata, Dist- Ahmednagar.
3Research Scholar Bhagwant University, Ajmer Rajasthan.
*Corresponding Author

Published In:   Volume - 15,      Issue - 11,     Year - 2022


ABSTRACT:
Stress is the disturbed homeostatic condition of the organism, and it is represented by non-specific response of the body to any demand imposed on it. Stress brings various changes in physiological condition of the organism, but various mechanism of the body will counteract to maintain homeostasis. Neurotip capsule is effective Ayurvedic treatment for stress related disorders. Neurotip capsules have unique combination of herbs like Jatamansi, Guduchi, Shankapushpi, Ashwagandha, and Probiotics. These herbs are known to sooth the mind, promote calmness and act as a stress buster. In present research study Neurotip formulation was screened for acute toxicity study and sub chronic oral toxicity study on adult albino mice. Animals were observed for behavioural changes, neurological changes and autonomic profile changes. There was no noticeable toxicity and death observed in animals when treated with highest dose of 5000mg/ kg of the formulation. Neurotip was tested on swimming endurance of mice. The results were compared with standard group treated with Geriforte. Test formulation was evaluated by chronic stress model in rats using Omeprazole as standard drug. Assessment of ulcer induction was done to check adaptogenic potential of Neurotip. Ulcer protection by test formulation was found to be 68.44% showing good antistress effects.


Cite this article:
Ravindra Bhimraj Laware, Santosh Bhausaheb Dighe, Braj Nandan Kishor. Evaluation of adaptogenic activity of Neurotip capsules by swimming endurance and chronic stress model. Research Journal of Pharmacy and Technology. 2022; 15(11):5307-3. doi: 10.52711/0974-360X.2022.00894

Cite(Electronic):
Ravindra Bhimraj Laware, Santosh Bhausaheb Dighe, Braj Nandan Kishor. Evaluation of adaptogenic activity of Neurotip capsules by swimming endurance and chronic stress model. Research Journal of Pharmacy and Technology. 2022; 15(11):5307-3. doi: 10.52711/0974-360X.2022.00894   Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-11-79


REFERENCES:
1.    Selye H. A syndrome produced by Diverse Nocuous agents. J Neuropsychiatry Clin Neurosci. 1998; 10(2):230-1.
2.    Brown KI, Nestor KE. Some Physiological Responses of Turkeys Selected for High and Low Adrenal Response to Cold Stress. PouL. Sci. 1973 Sep; 52(5):1948-54.doi: 10.3382/ps.0521948.
3.    Pawar S, Shivakumar VH. A current status of adaptogens: natural remedy to stress. As. Pac. J. Trop. Dis. 2012; 2(1): S480- S490. DOI:10.1016/S2222-1808 (12) 60207-2
4.    Ramnath V, Rekha PS, Brahma Rasayana enhances in vivo antioxidant status in cold-stressed chickens (Gallus gallus domesticus). Ind. J. Pharmacol. 2009 Jun; 419 (3): 115-119.
5.    Gupta V, Lahiri SS, Sultana S, Kumar R. Mechanism of action of Rhodiola imgricata Edgew during exposure to cold, hypoxia and restraint (C-H-R) stress induced hypothermia and post stress recovery in rats. Food. Chem. Toxicol. 2009; 47: 1239-45.
6.    OECD. Acute oral toxicity. Acute oral toxic class method guideline 423 adopted 23.03.1996. In: Eleventh Addendum to the, OECD, guidelines for the testing of chemicals, organization for economic co-operation and development, Paris. 2002.
7.    OECD. Repeated dose 28-day oral toxicity test method guideline 407 adopted 27.07.1995. In:OECD, Guidelines for testing of chemicals, Organization for economic cooperation and development, Paris.1995
8.    Mehta NP, Mehta SP, Joshi SR. P.J. Mehta’s Practical Medicine. The National Book Depot, Mumbai, India. 2003.
9.    Ghai CL. A Textbook of Practical Physiology. Jaypee Brothers, Medical Publishers (P) Ltd, New Delhi, India. 2005.
10.    Nelson DL and Cox MM. Lehninger Principle of Biochemisty. Worth Publishers Inc, New York, USA. 2003.
11.    Bhattacharya SK, Muruganandam AV. Adaptogenic activity of Withania somnifera: an experimental study using a rat model of chronic stress, Phar. Bioc. Beh. 2003; 75: 547-55.  DOI: 10.1016/s0091-3057(03)00110-2.
12.    Maity TK, Mandal SC, Saha BP, Pal M. Effect of Ocimum sanctum roots extract on swimming performance in mice, Phytother. Res. 2000 Mar; 14(2): 120-1. doi: 10.1002/(sici)1099-1573(200003)14:2<120::aid-ptr557>3.0.co;2-0.
13.    Singh B, Sharma SP, Goyal R. Evaluation of Geriforte, an herbal geriatric tonic, on antioxidant defense system in Wistar rats. Ann N Y Acad Sci. 1994 Jun 30; 717:170-3. doi:10.1111/j.1749-6632.1994.tb12084.x.
14.    Debnath J, Prakash T, Karki R, Kotresha D, Sharma P. An experimental evaluation of Anti-stress effects of Terminalia chebula, J. Physiol. Biomed. Sci. 2011; 24(2): 13-19.
15.    Vogel GH. Drug Discovery and Evaluation, Springer, New York, USA. 2002.
16.    Pasha S, Khaleel M, Som S. Evaluation of Adaptogenic Activity of Moringa oleifera Lam. Research J. Pharmacology and Pharmacodynamics 2010; 2(3):243-247
17.    Jahagirdar MAW, Hugar S, Patil VP, Khot A, Nanjappaiah HM. Screening of Antistress activity of Ficus benghalensis Fruit extract. Research J. Pharm. and Tech. 13(1): January 2020 doi: 10.5958/0974-360X.2020.00039.6


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