Author(s): Nilanjan Sarkar, Sara Farheen, Mainak Chakraborty, Swarupananda Mukherjee, Pallab Kanti Haldar

Email(s): pallab_haldar@rediffmail.com

DOI: 10.52711/0974-360X.2022.00887   

Address: Nilanjan Sarkar1-2, Sara Farheen1, Mainak Chakraborty1, Swarupananda Mukherjee1, Pallab Kanti Haldar2*
1Department of Pharmaceutical Technology, NSHM Knowledge Campus, Kolkata - Group of Institutions. Kolkata, West Bengal, India.
2Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal, India.
*Corresponding Author

Published In:   Volume - 15,      Issue - 11,     Year - 2022


ABSTRACT:
The present study was aimed to investigate the phytochemical Characterization, in vitro antioxidant and antidiabetic activity of Aerva sanguinolenta (L.) Blume. This is an herb belonging to the family Amaranthaceae. Traditionally the plant is rich sources of the constituents like tannins, flavonoids, terpenoids, sphingolipids, polyphenolic compounds etc. The extraction was carried out using chloroform and methanol in subsequent order of polarity. The phytochemical study was done for the identification of different bioactive compounds present in extract through the HR-LCMS study. For this study it is reported that various compounds like Thalidasine, Alpinine, Compactindiol lactone, 9Z- Octadecene dioic acid, Salviafiaside Methyl Ester, Capreomycin, Para Trifluoromethylphenol, Punicacortein B, a-Linolenic acid, Dicumarol, Euphorbia factor Ti2, Calotropin, Kaempferol 3-(2”,6”-di-(E)-p-coumarylglucoside), 6-Methylthiopurine ribonucleotide, Azelaic acid, Kaempferol 3-rhamnoside 7-xyloside, Quinolin-2-ol, Tiliroside, Amicinonide, Indoleacryli Acid, Benzocaine, Bellendine, Vindoline, Betamethasone, Fabianine, Hypercalin B, Icaceine, Canthin-6-one, Irinotecan, Convallasaponin A are present in this plant which are responsible for anti-inflammatory, anti-tumar, anti-malarial, anti-bacterial, anti-fungal, anti-cholesteremic, antiatherosclerotic, transdermal, antioxidant, anti-tubercular, anti-cancer, anticoagulant, antiangina, antihypertension, anti-microbial, antiparasitic, antifungal, antiplatelet, antidiabetic, hepatoprotective, antiviral, antiallergic, immunosuppressive, antianalgesic, antidiabetic, antimitotic activities respectively. From this study it is revealed that leaves extract of Aerva sanguinolenta (L.) Blume exhibits potent antioxidant activity. The plant extract shows substantial DPPH radical scavenging, Hydroxyl radical scavenging, Nitric oxide radical scavenging, Superoxide radical scavenging activity compared to standard (Ascorbic acid). From this study it is reported that plant extract is a potent inhibitor of two key enzymes which are linked to type-2 diabetes mellitus like a-amylase and a-glucosidase.


Cite this article:
Nilanjan Sarkar, Sara Farheen, Mainak Chakraborty, Swarupananda Mukherjee, Pallab Kanti Haldar. Exploration of phytochemical and in-vitro antioxidant and antidiabetic properties of Aerva sanguinolenta (L.) Blume. Research Journal of Pharmacy and Technology. 2022; 15(11):5267-2. doi: 10.52711/0974-360X.2022.00887

Cite(Electronic):
Nilanjan Sarkar, Sara Farheen, Mainak Chakraborty, Swarupananda Mukherjee, Pallab Kanti Haldar. Exploration of phytochemical and in-vitro antioxidant and antidiabetic properties of Aerva sanguinolenta (L.) Blume. Research Journal of Pharmacy and Technology. 2022; 15(11):5267-2. doi: 10.52711/0974-360X.2022.00887   Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-11-72


REFERENCES:
1.     Kharroubi AT. Diabetes mellitus: The epidemic of the century. World J Diabetes. 2015; 6(6):850.
2.     Patel DK, Prasad SK, Kumar R, Hemalatha S. An overview on antidiabetic medicinal plants having insulin mimetic property. Asian Pac J Trop Biomed. 2012; 2(4):320–30.
3.     Saha U, Ghosh C, Mallick C. antihyperglycemic and antioxidative effect of hydro- methanolic extract of leaf of Abroma augusta in streptozotocin induced diabetic male Albino rat. Int J Pharm Sci Res. 2018; 9(9):3788.
4.     Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care. 2004 May; 27(5):1047-53. doi: 10.2337/diacare.27.5.1047. PMID: 15111519.
5.     Shettar AK, Vedamurthy AB. Studies on In-Vitro Antidiabetic Activities of Hopea ponga and Vitex leucoxylon. Int J Pharm Pharm Sci. 2017 Feb 1; 9(2):263.
6.     Keddagoda G, Piyumi W, Anoja PA, Kamani AP, Wijewardana J, Thilak P W, "Antidiabetic Activity of Widely Used Medicinal Plants in the Sri Lankan Traditional Healthcare System: New Insight to Medicinal Flora in Sri Lanka", Evidence-Based Complementary and Alternative Medicine, 2021, Article ID 6644004, https://doi.org/10.1155/2021/6644004.
7.     Sarker J, Ali MR, Khan MA, Rahman MM, Hossain AS, Alam AK. The Plant Aerva sanguinolenta: A Review on Traditional uses, Phytoconstituents and Pharmacological Activities. Pharmacogn Rev. 2021 Mar 1; 13(26):89-92.
8.     Reddy S, Reddy R, Reddy K Srinivas. Diuretic and anti-inflammatory activity of aqueous extract of Aerva sanguinolenta (L.) Blume. International Research Journal of Pharmacy. 2011; 2; 65-67.
9.     Lalee A, Bhattacharaya B, Das M, Mitra D, Kaity S, Bera S, Samanta A.  Hepatoprotective activity of ethanolic extract of Aerva sanguinolenta (Amaranthaceae) against paracetamol induced liver toxicity on Wistar Rats. NSHM Journal of Pharmacy and Healthcare Management. 2012:3:57-65.
10.     Nn A. A Review on the Extraction Methods Use in Medicinal Plants, Principle, Strength and Limitation. Med Aromat Plants. 2015; 04(03):3–8.
11.     Nalin Pagi DD, Payal Patel HJ. Antimicrobial Activity and Phytochemical Screening of Aloe vera (Aloe barbadensis Miller). Int J Curr Microbiol Appl Sci. 2017; 6(3):2152–62.
12.     Bharat P, Sagar R, Sulav R, Ankit P. Investigations of antioxidant and antibacterial activity of leaf extracts of Azadirachta indica. African J Biotechnol. 2015; 14(46):3159–63.
13.     Pavithra K, Vadivukkarasi S. Evaluation of free radical scavenging activity of various extracts of leaves from Kedrostis foetidissima (Jacq.) Cogn. Food Sci Hum Wellness. 2015; 4(1):42–6.
14.     Baral P, Dubey A, Tewari S, Vasmatkar P, Verma AK. Total Polyphenolic Contents and Antioxidant Activity of Leaf, Bark and Root of Adina cordifolia Benth. and Hook. J Pharm, Chem Biol Sci. 2016; 4(November):394–401.
15.     Hazra B, Biswas S, Mandal N. Antioxidant and free radical scavenging activity of Spondias pinnata. BMC Complement Altern Med. 2008; 8:1–10.
16.     Murty R, Sldv K, Das MC, Vijayaraghavan R, Shanmukha I. In vitro evaluation of antidiabetic activity of aqueous and ethanolic leaves extracts of Chloroxylon swietenia. 2017; 7(5):486–90.
17.     Kim Y, Choi D, Lee JH, Lee S. Alpha-Glucosidase Inhibitory Activity in Different Pepper Cultivars (Capsicum annuum L.). 2011; 444–50.
18.     Perez RM. Anti-inflammatory activity of compounds isolated from plants. ScientificWorldJournal. 2001; 1:713–84.
19.     Judefeind A, Van Rensburg PJ, Langelaar S, Wiechers JW, Du Plessis J. Quantitative determination of octadecenedioic acid in human skin and transdermal perfusates by gas chromatography-mass spectrometry. J Chromatogr Sci. 2008; 46(6):544–50.
20.     Choi WH. Evaluation of anti-tubercular activity of linolenic acid and conjugated-linoleic acid as effective inhibitors against Mycobacterium tuberculosis. Asian Pac J Trop Med. 2016; 9(2):125–9.
21.     Fürstenberger G, Hecker E. On the Active Principles of the Spurge Family (Euphorbiaceae) XI. [1] the Skin Irritant and Tumor Promoting Diterpene Esters of Euphorbia Tirucalli L. Originating from South Africa. Zeitschrift fur Naturforsch - Sect C J Biosci. 1985; 40(9–10):631–46.
22.     Calderón-Montaño JM, Burgos-Morón E, Pérez-Guerrero C, López-Lázaro M. A Review on the Dietary Flavonoid Kaempferol | BenthamScience. Mini Rev Med Chem. 2011;11(4):298–344.
23.     Ho DHW, Frei E. Pharmacological Studies of the Antitumor Agent 6-Methylthiopurine Ribonucleoside. Cancer Res. 1970;30(12):2852–7.
24.     Sweatt,S.K, Gower, B.A, Chieh, A.Y, Liu, Y, Li L. Enhanced therapeutic anti-inflammatory effect of betamethasone upon topical administration with low frequency, low intensity (20 kHz, 100 mW/cm2) ultrasound exposure on carrageenan-induced arthritis in mice model. Physiol Behav. 2016; 176(1):139–48.
25.     Grochowski DM, Locatelli M, Granica S, Cacciagrano F, Tomczyk M. A Review on the Dietary Flavonoid Tiliroside. Compr Rev Food Sci Food Saf. 2018; 17(5):1395–421.
26.     Wlodarska M, Luo C, Kolde R, d’Hennezel E, Annand JW, Heim CE, et al. Indoleacrylic Acid Produced by Commensal Peptostreptococcus Species Suppresses Inflammation. Cell Host Microbe. 2017; 22(1):25-37.
27.     Morrow ME, Berry CW. Properties of Topical Anestletc Liquids Conlaining Lidocaine or Benzocaine. Anesth Prog. 1988; 35:9–13.
28.     Goboza M, Aboua YG, Chegou N, Oguntibeju OO. Vindoline effectively ameliorated diabetes-induced hepatotoxicity by docking oxidative stress, inflammation and hypertriglyceridemia in type 2 diabetes-induced male Wistar rats. Biomed Pharmacother. 2019;112(January):108638.
29.     Sweatt, S.K, Gower, B.A, Chieh, A.Y, Liu, Y, Li L. Enhanced therapeutic anti-inflammatory effect of betamethasone upon topical administration with low frequency, low intensity (20 kHz, 100 mW/cm2) ultrasound exposure on carrageenan-induced arthritis in mice model. Physiol Behav. 2016;176(1):139–48.
30.     Osman K, Evangelopoulos D, Basavannacharya C, Gupta A, McHugh TD, Bhakta S, et al. An antibacterial from Hypericum acmosepalum inhibits ATP-dependent MurE ligase from Mycobacterium tuberculosis. Int J Antimicrob Agents. 2012; 39(2):124–9.
31.     Zhao F, Dai JK, Liu D, Wang SJ, Wang JR. Synthesis and evaluation of ester derivatives of 10-hydroxycanthin-6-one as potential antimicrobial agents. Molecules. 2016;21(3); 390; https://doi.org/10.3390/molecules21030390
32.     Fujita KI, Kubota Y, Ishida H, Sasaki Y. Irinotecan, a key chemotherapeutic drug for metastatic colorectal cancer. World J Gastroenterol. 2015;21(43):12234–48.
33.     N.C. Cook and S. Samman.Flavonoids---Chemistry, metabolism cardioprotective effects and dietary sources. Acta Medica Croat. 2009; 63:3–6.
34.     Academy CA, Town Y. Phytochemical Screening and Fourier Transform Infrared Spectroscopy (FT-IR) Analysis of Vernonia amygdalina Del (Bitter leaf) Methanol Leaf Extract. 2020;14(2):35–41.
35.     Kaczmarek B. Tannic acid with antiviral and antibacterial activity as a promising component of biomaterials-A minireview. Materials (Basel). 2020;13(14).
36.     Youness RA, Kamel R, Elkasabgy NA, Shao P, Farag MA. Recent advances in tannic acid (gallotannin) anticancer activities and drug delivery systems for efficacy improvement; a comprehensive review. Molecules. 2021; 9; 26(5):1486. doi: 10.3390/molecules26051486.  


Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags


Not Available