Nilanjan Sarkar, Sara Farheen, Mainak Chakraborty, Swarupananda Mukherjee, Pallab Kanti Haldar
Nilanjan Sarkar1-2, Sara Farheen1, Mainak Chakraborty1, Swarupananda Mukherjee1, Pallab Kanti Haldar2*
1Department of Pharmaceutical Technology, NSHM Knowledge Campus, Kolkata - Group of Institutions. Kolkata, West Bengal, India.
2Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal, India.
Volume - 15,
Issue - 11,
Year - 2022
The present study was aimed to investigate the phytochemical Characterization, in vitro antioxidant and antidiabetic activity of Aerva sanguinolenta (L.) Blume. This is an herb belonging to the family Amaranthaceae. Traditionally the plant is rich sources of the constituents like tannins, flavonoids, terpenoids, sphingolipids, polyphenolic compounds etc. The extraction was carried out using chloroform and methanol in subsequent order of polarity. The phytochemical study was done for the identification of different bioactive compounds present in extract through the HR-LCMS study. For this study it is reported that various compounds like Thalidasine, Alpinine, Compactindiol lactone, 9Z- Octadecene dioic acid, Salviafiaside Methyl Ester, Capreomycin, Para Trifluoromethylphenol, Punicacortein B, a-Linolenic acid, Dicumarol, Euphorbia factor Ti2, Calotropin, Kaempferol 3-(2”,6”-di-(E)-p-coumarylglucoside), 6-Methylthiopurine ribonucleotide, Azelaic acid, Kaempferol 3-rhamnoside 7-xyloside, Quinolin-2-ol, Tiliroside, Amicinonide, Indoleacryli Acid, Benzocaine, Bellendine, Vindoline, Betamethasone, Fabianine, Hypercalin B, Icaceine, Canthin-6-one, Irinotecan, Convallasaponin A are present in this plant which are responsible for anti-inflammatory, anti-tumar, anti-malarial, anti-bacterial, anti-fungal, anti-cholesteremic, antiatherosclerotic, transdermal, antioxidant, anti-tubercular, anti-cancer, anticoagulant, antiangina, antihypertension, anti-microbial, antiparasitic, antifungal, antiplatelet, antidiabetic, hepatoprotective, antiviral, antiallergic, immunosuppressive, antianalgesic, antidiabetic, antimitotic activities respectively. From this study it is revealed that leaves extract of Aerva sanguinolenta (L.) Blume exhibits potent antioxidant activity. The plant extract shows substantial DPPH radical scavenging, Hydroxyl radical scavenging, Nitric oxide radical scavenging, Superoxide radical scavenging activity compared to standard (Ascorbic acid). From this study it is reported that plant extract is a potent inhibitor of two key enzymes which are linked to type-2 diabetes mellitus like a-amylase and a-glucosidase.
Cite this article:
Nilanjan Sarkar, Sara Farheen, Mainak Chakraborty, Swarupananda Mukherjee, Pallab Kanti Haldar. Exploration of phytochemical and in-vitro antioxidant and antidiabetic properties of Aerva sanguinolenta (L.) Blume. Research Journal of Pharmacy and Technology. 2022; 15(11):5267-2. doi: 10.52711/0974-360X.2022.00887
Nilanjan Sarkar, Sara Farheen, Mainak Chakraborty, Swarupananda Mukherjee, Pallab Kanti Haldar. Exploration of phytochemical and in-vitro antioxidant and antidiabetic properties of Aerva sanguinolenta (L.) Blume. Research Journal of Pharmacy and Technology. 2022; 15(11):5267-2. doi: 10.52711/0974-360X.2022.00887 Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-11-72