Author(s): Gururaja MP, Nidhi P Shetty, Himanshu Joshi

Email(s): gurureceptor@gmail.com

DOI: 10.52711/0974-360X.2022.00822   

Address: Gururaja MP1*, Nidhi P Shetty1, Himanshu Joshi2
1Department of Pharmacology, NGSM Institute of Pharmaceutical Sciences, NITTE (Deemed to be University), Deralakatte, Mangaluru, Karnataka, India-575018.
2College of Pharmacy, Graphic Era Hill University, Bhimtal campus, Uttarakhnd, India- 263136.
*Corresponding Author

Published In:   Volume - 15,      Issue - 11,     Year - 2022


ABSTRACT:
The present study was undertaken to evaluate the effect of Panchagavya ghrita on experimentally induced anxiety in swiss albino mice. The study was carried out with an objective of scientifically validating the traditional claims and to compare the ancient knowledge with the latest pharmacological aspects of preclinical research. The Swiss albino mice were divided into 4 groups of 6 mice each. First group received vehicle 10mg/kg orally. Second group was treated with the standard drug diazepam (2mg/kg i.p) one hour before the experiment. Third and fourth group animals were treated with the two different doses of Panchagavya ghrita i.e., 4680mg/kg p.o and 6840mg/kg p.o once daily for 14 days. On the 15th day one hour after administration of the test dose, anti anxiety activity was evaluated using Elevated Plus maze model, Light Dark Transition model & Open field test. Animals treated with Panchagavya Ghrita showed significant result by increasing the number of entries into the open arm and time spent in open arm in Elevated Plus maze model. In Light & Dark Transition model, it showed increase in the Number of entries into the light chamber and time spent in the light chamber and in the open field test, the number of rearings, time spent in the central square and the number of squares crossed increased thus proving the antianxiety activity of Panchagavya ghrita.


Cite this article:
Gururaja MP, Nidhi P Shetty, Himanshu Joshi. Attenuation of Experimentally Induced Anxiety by Panchagavya Ghrita in Mice. Research Journal of Pharmacy and Technology. 2022; 15(11):4897-0. doi: 10.52711/0974-360X.2022.00822

Cite(Electronic):
Gururaja MP, Nidhi P Shetty, Himanshu Joshi. Attenuation of Experimentally Induced Anxiety by Panchagavya Ghrita in Mice. Research Journal of Pharmacy and Technology. 2022; 15(11):4897-0. doi: 10.52711/0974-360X.2022.00822   Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-11-7


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