Author(s): Gaurav Tiwari, Garima Singh, Ravi Shekhar, Ruchi Tiwari

Email(s): drgauravtiwari81@gmail.com , dr.gauravtiwari@psit.in

DOI: 10.52711/0974-360X.2022.00880   

Address: Gaurav Tiwari1*, Garima Singh1, Ravi Shekhar2*, Ruchi Tiwari1
1Pranveer Singh Institute of Technology (Pharmacy), Kanpur. India.
2Department of Pharmacy, Dr Bhimrao Ambedkar University, Agra, India.
*Corresponding Author

Published In:   Volume - 15,      Issue - 11,     Year - 2022


ABSTRACT:
The present study aims at the development and evaluation of dental gel containing metronidazole non-biodegradable polymers for targeted delivery of drug and thus prolonging the action. Hot Method was used for the preparation of gel. Natural polymers like, Guar gum, Sodium alginate, Chitosan, Xanthan gum, Gellan gum were used in the formulations of gel. Prepared gels were evaluated for pH, rheological study, spreadability study, gelation, and gel melting study. At last Field Emission Scanning Electron Microscopy FESEM, Differential Scanning Calorimetry (DSC), Thermo Gravimetric Analysis (TGA), Texture Profile Analysis (TPA) have been done on an optimized gel formulation. All gels revealed pH ranged between 6.16 to 6.47, spreadability between 28.37 to 45.03 g.cm/sec, drug content between 90.01 to 99.10 % viscosity ranged between 3108.44 cps and 3645.47 cps and formulations F3 and F10 showed gelation temperature 39±0.12OC and 37±0.13OC respectively which is similar to the temperature of the body. Surface of the sample gels showed no drug particles, indicating a homogeneous mixture of polymers of drugs as well as natural agents. Formulation F10 containing Guar gum showed slower degradation in all media as compared to gels made of Sodium alginate, Xanthan gum, Chitosan, Gellan gum. DSC results revealed that the drug has the same state in the optimized formulation. TGA results showed that the formulation was found to have high stability in high-temperature settings. TPA results of optimized F10 revealed the parameters Mucoadhesive strength 92.54 ± 2.65 g, Hardness 25.34 ± 0.01N/mm², Compressibility 57.75 ± 0.40N mm, Adhesiveness-4.56 ± 0.26 N mm, Cohesiveness 0.83 ± 0.06. Hence, it is concluded that Metronidazole gel with gellan gum showed a longer degradation time and guar gum showed slower degradation in all over polymers used in gel formulations.


Cite this article:
Gaurav Tiwari, Garima Singh, Ravi Shekhar, Ruchi Tiwari. Development and qualitative evaluation of periodontal gel containing an antibacterial agent for periodontal disease. Research Journal of Pharmacy and Technology. 2022; 15(11):5225-1. doi: 10.52711/0974-360X.2022.00880

Cite(Electronic):
Gaurav Tiwari, Garima Singh, Ravi Shekhar, Ruchi Tiwari. Development and qualitative evaluation of periodontal gel containing an antibacterial agent for periodontal disease. Research Journal of Pharmacy and Technology. 2022; 15(11):5225-1. doi: 10.52711/0974-360X.2022.00880   Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-11-65


REFERENCES:
1.    Anjana S, Beena P, Shahana S, Namitha Navas, Sam Cherian Mathew, Salikh Salim, Elessy Abraham. Formulation and Evaluation of Intrapacket Dental Film of Antibacterial agent for Periodontitis. Research J Pharm and Tech. 2021;14(5):2750-6. DOI: 10.52711/0974-360X.2021.00485.
2.    Sanjay M, Priya LG. A Preliminary Study to compare The Pain Perception of Topical gel Versus Injected Local Infiltration/Block Anaesthesia during Non-Surgical Periodontal Therapy. Research J Pharm and Tech. 2018;11:4257-4262. DOI: 10.5958/0974-360X.2018.00780.1.
3.    Tiwari G, Tiwari R, Srivastava B, Rai AK. Design and Evaluation of Target Retentive Device Containing Metronidazole for the Treatment of Periodontal disease. Research J Pharm and Tech. 2008;1(4):390-394.
4.    Tiwari G, Tiwari R, Srivastava B, Rai AK. Development and optimization of multi-unit solid dispersion systems of poorly water-soluble drug. Research J Pharm and Tech. 2008;1(4):444-449.
5.    Ahamed SA, Murugan T. Periodontal Vaccine as Host Modulating Agent in Periodontal Therapy – An Overview. Research J Pharm and Tech. 2016;9(7):972-976. DOI: 10.5958/0974-360X.2016.00186.4.
6.    Jeganath S, Asha D, Kumar SS, Nair KS, Kumaran SK. Oral Controlled Drug Delivery System – A Review. Research J Pharm and Tech. 2018;11(2):797-804. DOI: 10.5958/0974-360X.2018.00151.8.  
7.    Gururajbhat A, Kulyadi GP, Tippavajhala VK. A Comprehensive Review on Formulation, Preparation, Evaluation and Applications of Medicated Chewing Gum. Research J Pharm and Tech. 2021;14(3):1760-1766. DOI: 10.5958/0974-360X.2021.00313.9.
8.    Gorle AP, Gattani SG. Design and evaluation of polymeric ocular drug delivery system. Chem Pharm Bull. 2009;57:914-9.  DOI: 10.1248/cpb.57.914.
9.    Patil SB, Murthy SR. Preparation and in vitro evaluation of mucoadhesive chitosan microspheres of amlodipine besylate for nasal administration. Indian J Pharm Sci. 2006;68:64-5. DOI: 10.4103/0250-474X.22966.
10.    Kassab HJ, Thomas LM, Jabir SA. Development and Physical Characterization of A Periodontal Bioadhesive gel of Gatifloxacin. Int J App Pharm. 2017;9:31-6. DOI: https://doi.org/10.22159/ijap.2017v9i3.7056.
11.    Switała-Zeliazkow M. Thermal degradation of copolymers of styrene with dicarboxylic acids—II: copolymers obtained by radical copolymerization of styrene with maleic acid or fumaric acid. Polym Degrad Stab. 2006;91:1233–39.  DOI: 10.1016/j.polymdegradstab.2005.09.006.
12.    Jones DS, Woolfson AD, Brown AF, Neill MJ.  Mucoadhesive, syringeable drug delivery system for controlled application of metronidazole to the periodontal pocket: in vitro release kinetics, syringeability, mechanical and mucoadhesive properties. J Control Rel. 1997;49:71–9. DOI: 10.1016/s0168-3659(97)00060-6.
13.    Rosevear FB. The microscopy of the liquid crystalline neat and middle phases of soaps and synthetic detergents.  J Am Oil Chem Soc. 1954;31:628-38.  DOI: 10.1007/BF02545595.
14.    Nagaraja P, Sunitha KR, Vasantha RA, Yathirajan HS. Spectrophotometric determination of metronidazole and tinidazole in pharmaceutical preparations. J Pharm Biomed Anal. 2002;28:527-35. DOI: 10.1016/s0731-7085(01)00685-9.
15.    Mounika S, Savitha G. Association of Periodontal Diseases and Metabolic Syndrome. Research J. Pharm. and Tech. 8(8):2015;994-996. DOI: 10.5958/0974-360X.2015.00166.3.
16.    Sinar Y, Setyawati S, Sumarno, Handono K. The Effect of Eleutherine americana Merr. Extract on Expression Changes of MMP-8 and Type 1 Collagen in Periodontitis Rat Models. Research J Pharm and Tech. 2020;13(5):2407-2412. DOI: 10.5958/0974-360X.2020.00432.1.
17.    Baghwan RR, Ambekar AW, Tamboli SS. Formulation, Development and Evaluation of in-situ Periodontal Gel Containing Ofloxacin. Research J Pharm and Tech. 2021;14(9):4609-4. DOI: 10.52711/0974-360X.2021.00801.
18.    Desai UD, Baruwala KD, Mistry SH, Jadhav AG. Characterization of Gel Formulation for the Treatment of Periodontal Disease. Research J Pharm and Tech. 2011;4(7):1073-1077.
19.    Tiwari G, Tiwari R, Rai AK. Studies on development of controlled delivery of combination drug(s) to Periodontal pocket. Indian J Dent Res. 2010;21:72-83. DOI: 10.4103/0970-9290.62814.
20.    Tiwari G, Tiwari R, Srivastava B, Rai AK. Design and Evaluation of Target Retentive Device Containing Metronidazole for the Treatment of Periodontal disease. Research J Pharm and Tech. 2008;1(4):390-394.
21.    Tiwari G, Tiwari R, Singh R. Allopurinol Loaded Transferosomes for the Alleviation of Symptomatic After-effects of Gout: An Account of Pharmaceutical Implications. Curr Drug Ther. 2020;15:404. DOI: 10.2174/1574885515666200120124214.
22.    Karthik EVG, Raj JD. Effect of Periodontal Diseases on Pulp Volume- A CBCT Analysis. Research J Pharm and Tech. 2018;11(11):4866-4869. DOI: 10.5958/0974-360X.2018.00885.5.  

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