Author(s): Jasmine Chaudhary, Akash Jain, Anns Sabu, Priyanka Jha, Prerna Sarup, Vishal Sharma, Diksha Sharma


DOI: 10.52711/0974-360X.2022.00870   

Address: Jasmine Chaudhary1*, Akash Jain1, Anns Sabu1, Priyanka Jha1, Prerna Sarup2, Vishal Sharma1, Diksha Sharma3
1MM College of Pharmacy, Maharishi Markandeshwer (Deemed to be University), Mullana, Ambala-133207, Haryana, India.
2Swami Vivekanand Institute of Pharmacy, Banur, Punjab, India.
3Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra.
*Corresponding Author

Published In:   Volume - 15,      Issue - 11,     Year - 2022

Schleichera oleosa (Lour.) Oken or Kusum, belonging to family Sapindaceae is an important medicinal plant reported to possess various pharmacological activities viz. analgesic, antibiotic, anti-dysentery, anti-helminthic, antioxidant and anticancer activities. Scientific studies reporting antihelminthic properties of bark extract of this plant are still lacking, therefore, the present work has been designed to investigate the ethanolic and ethyl acetate extracts of bark for its antihelminthic potential. Antihelminthic evaluation was done using Indian earthworms, Pheretima posthuma by determining time of paralysis and death. Phytochemical screening of the extracts revealed the presence of flavonoids, tannins and phenolic acids. The anti-helminthic activity of both extracts (0.1%) was found better than the standard drug Albendazole. Since, both extracts showed promising results, they can be further helpful in designing herbal formulations for commercial use.dry-powder inhaler (DPI) carries medication to lungs as a dry powder, useful against respiratory diseases.

Cite this article:
Jasmine Chaudhary, Akash Jain, Anns Sabu, Priyanka Jha, Prerna Sarup, Vishal Sharma, Diksha Sharma. Exploring Schleichera oleasa crude bark extract for its anti-helminthic potential. Research Journal of Pharmacy and Technology. 2022; 15(11):5168-1. doi: 10.52711/0974-360X.2022.00870

Jasmine Chaudhary, Akash Jain, Anns Sabu, Priyanka Jha, Prerna Sarup, Vishal Sharma, Diksha Sharma. Exploring Schleichera oleasa crude bark extract for its anti-helminthic potential. Research Journal of Pharmacy and Technology. 2022; 15(11):5168-1. doi: 10.52711/0974-360X.2022.00870   Available on:

1.    Lone PA. Bhardwaj AK. Shah KW. Tabusam S. Ethnobotanical survey of some threatened medicinal plants of Kashmir Himalaya. Indian Journal of Medical Research. 2014; 8(47):1362-1373. doi: org/10.5897/JMPR2014.5649
2.    Ahvazi M. Sigaroodi FK. Charkhchiyan MM. Mojab F. Mozaffarian VA. Zakerif, H. Introduction of medicinal plants species with the most traditional usage in Alamut region. Iranian Journal of Pharmaceutical Sciences. 2012; 11(1):185–194.
3.    Singh R. Medicinal plants: A review. Journal of plant Sciences. 2015; 3(1-1):50-55. doi: org/10.11648/j.jps.s.2015030101.18
4.    Devprakash, Sumalatha BV, Srinivasan KK, Savitha. Tephrosia purpurea (Linn.)Pers.-A Comprehensive Review. Research Journal of Pharmacognosy and Phytochemistry. 2012; 4(2):134-143.
5.    Gangola S. Khati P. Bhatt P. Parul. Sharma A. India as the heritage of medicinal plant and their use. Current Trends in Biomedical Engineering & Biosciences. 2017; 4(4):50. doi: org/10.19080/CTBEB.2017.04.555641
6.    Shakya AK. Medicinal plants: Future source of new drugs. International Journal of Herbal Medicine. 2016; 4(4): 59-64. doi: org/10.13140/RG.2.1.1395.6085
7.    Karagoz A. Artun FT. Ozcan G. Melikoglu G. Sezin A. Kultur S. Sutlupınar N. In vitro evaluation of antioxidant activity of some plant methanol extracts. Biotechnology & Biotechnological Equipment. 2015; 29(6):1184-1189. doi: 10.1080/13102818.2015.1080600
8.    Jeyabaskar S, Viswanathan T, Mahendran R, Rathisre PR, Nishandhini M. Comparative quantitative screening of secondary phytoconstituents from the leaves extract of Sterculia foetida Linn. Research Journal of Pharmacy and Technology. 2017; 10(9):2907-2912. doi: 10.5958/0974-360X.2017.00513.3
9.    Philomena G. Concerns regarding the safety and toxicity of medicinal plants - An overview. Journal of Applied Pharmaceutical Sciences. 2011; 01(06):40-44. doi: org/10.1016/j.heliyon.2020.e04150
10.    Chattopadhyay RR. Bhattacharyya SK. Terminalia chebula: An update. Pharmacognosy Reviews. 2007; 1(1): 151-156.
11.    Bhargavi S, Swamy V, Kumari SM, Ushasri S, Kumari PM. Antimicrobial and wound healing activities of leaves of Solanum erianthum D. Don. Research Journal of Pharmacy and Technology. 2013;6(5): 531-536.
12.    Gowri SS. In vitro anticancer activity of Majidea zanquebarica J. Krik. ex Oliv. (Sapindaceae). Research Journal of Science and Technology. 2020;12(3):173-176. doi: 10.5958/2349-2988.2020.00023.6
13.    Oladeji OS. Oyebamiji AK. Stellaria media (L.) Vill.- A plant with immense therapeutic potentials: Phytochemistry and Pharmacology. Heliyon. 2020; 6(6):e04150.
14.    Atanasov AG. Waltenberger B. Wenzig EMP. Linder T. Wawrosch C. Uhrin P. Temml V. Wang L. Schwaiger S. Heiss EH. Rollinger JM. Schuster D. Breuss JM. Bochkov V. Mihovilovic MD. Kopp B. Bauer R. Dirsch VM. Stuppner H. Discovery and resupply of pharmacologically active plant- derived natural products: A review. Pharmaceutical Biology. 2015; 33(8):1582–1614. doi: org/10.1016/j.biotechadv.2015.08.001
15.    Srinivas K. Baboo RVC. GC-MS study of Schleichera oleosa. International Journal of Current Pharmaceutical Research. 2011; 2(2):1-11.
16.    Ghosh P. Chakraborty P. Mandal A. Saha A. Triterpenoids from Schleichera oleosa of Darjeeling foothills and their antimicrobial activity. Indian Journal of Pharmaceutical Sciences. 2011; 73(2):231-3. doi: 10.4103/0250-474x.91568
17.    Khan MJ. Saraf S. Saraf S. Anti-inflammatory and associated analgesic activities of HPLC standardized alcoholic extract of known ayurvedic plant Schleichera oleosa. Journal of Ethnopharmacoogy.. 2017; 197:257–65. doi: org/10.1016/j.jep.2016.08.021
18.    Mahaptma SP. Sahoo HP. An ethno-medico-botanical study of Bolangir, Orissa, India: Native plant remedies against gynaecological diseases. Ethnobotanical Leaflets. 2008; 12:846-50.
19.    Goswami S. Singh RP. Ayurvedic, phytochemical and pharmacological review of Schleichera oleosa (Lour.) Oken: A traditional plant with enormous biological activity. World Journal of Pharmaceutical Research. 2017; 6: 295-309. doi: org/10.20959/wjpr201710-9370
20.    Chan MK. Khine ZWL. Nwet NW. Hla N. Investigation of phytochemical constituents and some biochemical properties of the bark of Schleichera oleosa (Lour.) Oken. (GYO). Journal of the Myanmar Academy of Arts and Science. 2019; XVII(1A):477-495.
21.    Jose S. Dandapat S. Sinha MP. Anti-hypertensive activity of aqueous and methanolic leaf extracts of Schleichera oleosa (Lour.) Merr. Journal of Analytical & Pharmaceutical Research. 2019; 8(3):94-97. doi: org/10.15406/japlr.2019.08.00320
22.    Hobanthad T. Maneetong, S. Simple extraction for the scanning of antioxidant activity of vegetables and fruits in Buriram, Thailand by DPPH, ABTS and FRAP assays. SNRU Journal of Science and Technology. 2019; 11(3):114-121.
23.    Toobpeng N. Powthong P. Suntornthiticharoen P. Evaluation of antioxidant and antibacterial activities of fresh and freeze-dried selected fruit juices. Asian Journal of Pharmaceutical and Clinical Research. 2017; 10(9):156-160.
24.    Khandekar U. Bobade A. Ghongade R. Evaluation of antioxidant activity, in-vitro antimicrobial activity and phytoconstituents of Schleichera oleosa (Lour.) Oken. International Journal of Biological & Pharmaceutical Research. 2015; 6(2): 137-143.
25.    Srinivas K. Baboo RVC. Antioxidant activity of ethanolic extract of stem bark of Schleichera oleosa (Lour. Oken). International Journal of Pharmacotherapeutics. 2013; 3(1):12-14.
26.    Thind T. Agrawal S. Saxena A. Arora S. Evaluation of cytotoxic and radical scavenging activities of root extracts of Schleichera oleosa (Lour.) Oken. Natural Product Research. 2015; 26(18): 1728–31. doi: org/10.1080/14786419.2011.606547
27.    Prasad B. Subedi L. Medicinal plant diversity and their pharmacological aspects of Nepal Himalayas. Pharmacognosy Journal. 2011; 3:6-17. doi: org/10.5530/pj.2011.25.2
28.    Santha ML. Kanchana P. Shakeela SK. Anti-inflammatory and anti-arthritic activity of Scheilchera oleosa (Lour.) Oken bark. International Journal of Pharmaceutical Sciences Review and Research. 2017; 46(1):79-84.
29.    Bhatia H. Kaur J. Nandi S. Gurnani V. Chowdhury A. Reddy PH. Vashishtha V. Rathi B. A review on Schleichera oleosa: Pharmacological and environmental aspects. Journal of Pharmaceutical Research. 2013; 6(1):224-229. doi: org/10.1016/j.jopr.2012.11.003
30.    Kirtikar KR. Basu BD. Indian medicinal plants. 1981; 1:794-795. Lalit Mohan Basu Publishing, Allahabad.
31.    Mall TP. Tripathi SC. Kusum- a multipurpose plant from Katarniaghat wildlife sanctury of Bahraich (UP) India-a review. World Journal of Pharmaceutical Research. 2017; 6(4):463-477. doi: org/10.20959/wjpr20174-8082
32.    Meshram N. Ojha M. Singh A. Alexander A. Ajazuddin. Sharma M. Significance and traditional medicinal properties of Schleichera oleosa. Asian Journal of Pharmaceutical Research. 2015; 5(1): 61-64. doi: org/10.5958/2231-5691.2015.00009.X
33.    Soundararajan M. Sivakkumar T. Pharmacognostical investigation and phytochemical studies of Schleichera oleosa. International Journal of Research in Pharmaceutical Sciences. 2017; 8(2):109-119.
34.    Goswami S. Singh RP. In vitro assessment of anthelmintic and alpha-amylase inhibition of Schleichera oleosa (lour.) Oken leaf extracts. Asian Journal of Pharmaceutical and Clinical Research. 2018; 11(9):487-491. doi: org/10.22159/ajpcr.2018.v11i9.28338
35.    Blair P. Demeart D. Update on prevention and treatment of intestinal helminth infections. Current Infectious Disease Reports. 2015; 17(3): 465. doi: org/10.1007/s11908-015-0465-x.
36.    Harindran J, Rajalakshmi GR. In vitro anthelmintic activity of Samadera indica. Research Journal of Pharmacy and Technology. 2011;4(10): 1593-1595.
37.    Kousalya M, Geetha P, Jesuraja A, Vinoth KM. In-Vitro study of anthelmintic activity of  Eclipta prostrata (L) y various Extracts. Research Journal of Pharmacy and Technology. 2017; 10(1): 58-60.doi: 10.5958/0974-360X.2017.00014.2
38.    Shabi RR, Ajina S. Qualitative phytochemical screening and in-vitro anthelmintic activity of Adhatoda vasica (Acanthaceae). Research Journal of Pharmacy and Technology. 2017; 10(2):414-420. doi: 10.5958/0974-360X.2017.00083.X
39.    Siju EN, Rajalakshmi GR, Hariraj N, Sreejith KR, Sudhakaran S, Muneer EK, Premalatha K. In-vitro anthelmintic activity of Mussaenda frondosa. Research Journal of Pharmacy and Technology. 2010; 3(1):151-153.
40.    Dubey RS. Shukla R. Pandey V. Shukla AK. Investigations on Drosera regia and Schleichera oleosa leaves for anthelmintic activity. Advance Pharmaceutical Journal. 2019; 4(4):97-99. doi:  org/10.31024/apj.2019.4.4.1
41.    Goswami S, Singh RP, Gilhotra RM. HPTLC Fingerprinting of Quercetin and comparative assessment of Anthelmintic potency against Eudrilus eugeniae of Schleichera oleosa (Lour) Oken and Tagetes eretca Linn. Research Journal of Pharmacy and Technology. 2020; 13(12):5699-5704. doi: 10.5958/0974-360X.2020.00992.0
42.    Kokate CK. Pharmacognosy. 2004: 109-113. Nirali Prakashan Publishing, Pune, India.
43.    Jork H. Funk W. Fischer W. Wimmer H. Thin layer chromatography: reagent and detection methods. 1990: 195. Weinhein: Weinheim, Basel (Switzerland) Publishing, Cambridge, New York.
44.    Khandelwal KR. Kokate CK. Pawar AP. Gokhale SB. Practical Pharmacognosy. 1988: 31-40. Nirali Prakashan Publishing, Pune, India.
45.    Harbone JB. A guide to modern techniques of plant analysis. 1981:1. Chapman & Hall Publishing, London.
46.    Kumar KIA. Manickam MS. Sreejith M. Sebastin V. In vitro antioxidant and anthelmintic activity of the extracts of whole plant Crotalaria biflora (L). Annals of the Romanian Society for Cell Biology. 2021; 25(4):150-161.
47.    Indirayati N. Nisa K. Kurang RY. Tarmo NC. Adang KTP. Radical scavenging activity and total phenolic content of seven tropical plants. IOP Conference Series: Earth and Environmental Science. 2020; 462:1-7. doi: org/10.1088/1755-1315/462/1/012043
48.    Ajaiyeoba EO. Onocha PA. Olarenwaju OT. In vitro anthelmintic properties of Buchholzia coriaceae and Gynandropsis gynandra extract. Pharmaceutical Biology. 2001; 39:217-20. doi: org/10.1076/phbi.

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

56th percentile
Powered by  Scopus

SCImago Journal & Country Rank

Recent Articles


Not Available