Author(s): Yazan Batineh, Qutaiba Ahmed Al Khames Aga, Kawthar Faris Nassir, Tharwat I Sulaiman, Ali Abbas Al-Gharawi, Jawad I Rasheed, Zaid Al Madfai, Mutaz A. Sheikh Salem, Luma Ahmed Al Khames Aga, Manhal Yasseen Rijab Agha, Eamon Abdullah

Email(s): qutaiba975@gmail.com , qibrahim@philadelphia.ed.jo

DOI: 10.52711/0974-360X.2022.00863   

Address: Yazan Batineh1, Qutaiba Ahmed Al Khames Aga1*, Kawthar Faris Nassir2, Tharwat I Sulaiman2, Ali Abbas Al-Gharawi2, Jawad I Rasheed2, Zaid Al Madfai3, Mutaz A. Sheikh Salem1, Luma Ahmed Al Khames Aga4, Manhal Yasseen Rijab Agha5, Eamon Abdullah6
1Department of Clinical Sciences, Faculty of Pharmacy, Philadelphia University, Amman, Jordan.
2Bagdad Teaching Hospital, Medical City Baghdad, Iraq.
3College of Medicine, Baghdad University, Baghdad, Iraq.
4COVID-19 Testing Specialist Atechy Group Cardiff, Wales, UK.
5University Hospital of Wales, Department of Orthopedic Cardiff, UK.
6St. George’s University, Grenada, West Indies.
*Corresponding Author

Published In:   Volume - 15,      Issue - 11,     Year - 2022


ABSTRACT:
Statins, which are widely used to treat hypercholesterolemia, have anti-inflammatory and antioxidant effects, upregulate angiotensin-converting enzyme 2 (ACE2) receptors, which happen to be SARS-CoV-2’s gateway into cells. This study aims to analyse the effects of Fenofibrate in comparison to Statins and a control group in patients with COVID-19. This is a retrospective open blind observational study of cohort of 300 patients experienced COVID-19 (symptoms’ severity varied between patients). The participants were divided into three cohorts; a control group received standard COVID-19 treatment (n=100); a second group (n=100) of patients who were on Statins, in addition they received the standard treatment; and a third cohort for patients who were already taking Fenofibrate (TRICOR®) as a medication to treat hyperlipidemia (n=100). Most symptoms (including cough, exertional dyspnoea, SOB, sore throat, sneezing, headache, tiredness, agitation, diarrhoea, joint pain, insomnia, myalgia, and fatigue) were less prevalent for patients who administered antihyperlipidemic drugs compared to the control group. Patients who were already taking Cholesterol-lowering medication presented with symptoms varied between mild to severe. Patients on Statins or Fenofibrate also showed less tachycardia and tachypnoea compared to those who were not on antihyperlipidemic drugs, and also the need for oxygen and ICU admission were less frequent. The length of stay in hospital was shorter in patients who were already on Statins or Fenofibrate. Both Statins and Fenofibrate have improved the outcome and the severity of symptoms for patients with Covid 19 infection.


Cite this article:
Yazan Batineh, Qutaiba Ahmed Al Khames Aga, Kawthar Faris Nassir, Tharwat I Sulaiman, Ali Abbas Al-Gharawi, Jawad I Rasheed, Zaid Al Madfai, Mutaz A. Sheikh Salem, Luma Ahmed Al Khames Aga, Manhal Yasseen Rijab Agha, Eamon Abdullah. Fenofibrate and Statins in Patients with COVID-19. Research Journal of Pharmacy and Technology. 2022; 15(11):5132-8. doi: 10.52711/0974-360X.2022.00863

Cite(Electronic):
Yazan Batineh, Qutaiba Ahmed Al Khames Aga, Kawthar Faris Nassir, Tharwat I Sulaiman, Ali Abbas Al-Gharawi, Jawad I Rasheed, Zaid Al Madfai, Mutaz A. Sheikh Salem, Luma Ahmed Al Khames Aga, Manhal Yasseen Rijab Agha, Eamon Abdullah. Fenofibrate and Statins in Patients with COVID-19. Research Journal of Pharmacy and Technology. 2022; 15(11):5132-8. doi: 10.52711/0974-360X.2022.00863   Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-11-48


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