ABSTRACT:
Context: Humic acid (HA), a naturally occurring chemical compound, is now being studied for medicinal applications. Paclitaxel (PTX), a strong anticancer agent, has a low water solubility, resulting in limited bioavailability following oral administration, improper tissue localisation, and poor therapeutic use. The goal of this study is to see if PTX can be complexed with HA to improve its solubility and bioavailability effectiveness. Materials and procedures: Differential scanning calorimetry, Fourier Transform Infrared spectroscopy, X-ray diffraction, and scanning electron microscopy were used to analyse complexes produced by solvent evaporation in varied weight ratios. Conclusion: Using HA to enhance the solubility and bioavailability of medicines is a beneficial method.
Cite this article:
Sachin D. Rede, Rupal K. Jani. Solubility Enhancement of Paclitaxel by Using Biomaterial. Solubility Enhancement of Paclitaxel by Using Biomaterial. Research Journal of Pharmacy and Technology. 2022; 15(11):5089-3. doi: 10.52711/0974-360X.2022.00855
Cite(Electronic):
Sachin D. Rede, Rupal K. Jani. Solubility Enhancement of Paclitaxel by Using Biomaterial. Solubility Enhancement of Paclitaxel by Using Biomaterial. Research Journal of Pharmacy and Technology. 2022; 15(11):5089-3. doi: 10.52711/0974-360X.2022.00855 Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-11-40
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