Chinky Goyal, Pankaj Bhatt, Shivani Rawat, Vipin Kumar Sharma, Meena Rani Ahuja
email@example.com , firstname.lastname@example.org , email@example.com , firstname.lastname@example.org , email@example.com
Chinky Goyal1*, Pankaj Bhatt2, Shivani Rawat3, Vipin Kumar Sharma4, Meena Rani Ahuja5
1Associate Professor and HOD, Deptt. of Rasa Shastra and Bhaishjya Kalpana, Saraswati Ayurveda Hospital and Medical College, Gharuan, Mohali.
2Assistant Professor, Department of Pharmaceutics, KIET School of Pharmacy, KIET Group of Institutions, Muradnagar, Ghaziabad, Uttar Pradesh.
3Medical Officer, Uttarakhand.
4Assistant Professor, Dept. of Pharmaceutical Sciences, Gurukul Kangri (Deemed to be University), Haridwar, Uttarakhand.
5Professor, Deptt. of Rasa Shastra and Bhaishjya Kalpana, Gurukul Campus, Uttrakhand Ayurveda University, Haridwar.
Volume - 15,
Issue - 11,
Year - 2022
Background: Stability being the potential of any particular preparation in a noteworthy container/closure set up to abide within its physical, microbiological, chemical, toxicological, therapeutic stipulations which is invariably manifested in respect of shelf-life. Main aim of present analysis is to ascertain the shelf-life of Balachaturbhadrika Syrup prepared with different sweetening agent viz. Sugar (Sample I), Jaggery (Sample II), Honey (Sample III) and Stevia (Sample IV). The study was performed under accelerated storage conditions. Methods: Accelerated stability study was conducted for 3 months as per ICH guideline QA1 (R2) and the changes in physico-chemical traits viz. pH, refractive index, specific gravity, alcohol content and sedimentation rate were inscripted for quadruple alliance of 0, 15, 30 and 90 days. The statistical analysis was done using mean ± SEM, student paired t- test and Analysis of Variance (ANOVA). Results: Remarkable changes were found in both organoleptic and physico-chemical traits. Extrapolated shelf-life of Sample I, II, III and IV from physico-chemical attributes in conformity with the weather conditions prevailing in India were 73.514 month (6.12 year), 76.080 month (6.340 year), 58.05 month (4.83 year) and 37.05 month (3.09 year) respectively. Conclusion: The syrups prepared using Sugar, Jaggery and Honey were found to be more stable than those prepared using Stevia as the value of physical parameters was found more prominent for honey, jaggery and sugar.
Cite this article:
Chinky Goyal, Pankaj Bhatt, Shivani Rawat, Vipin Kumar Sharma, Meena Rani Ahuja. Estimation of shelf-life of Balachaturbhadrika syrup containing different sweetening agents. Research Journal of Pharmacy and Technology. 2022; 15(11):5078-3. doi: 10.52711/0974-360X.2022.00853
Chinky Goyal, Pankaj Bhatt, Shivani Rawat, Vipin Kumar Sharma, Meena Rani Ahuja. Estimation of shelf-life of Balachaturbhadrika syrup containing different sweetening agents. Research Journal of Pharmacy and Technology. 2022; 15(11):5078-3. doi: 10.52711/0974-360X.2022.00853 Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-11-38
1. B. Soujanya, G. Pavani Priya, T.E.G.K. Murthy. Studies on Influence of Coprocessed Excipients on Flow and Dissolution Kinetics of Diclofenac Sodium. Res. J. Pharm. Dosage Form. and Tech. 7(1): Jan.-Mar. 2015; Page 51-58. doi: 10.5958/0975-4377.2015.00008.7
2. Anil Kumar Sahdev, Somya Purwa. Process involves in the formation of tablet for novel drug delivery system.Asian J. Res. Pharm. Sci. 2018; 8(4): 203-209. doi: 10.5958/2231-5659.2018.00034.6
3. Sandesh Narayan Somnache, Ajeet Madhukar Godbole, Pankaj Sadashiv Gajare, Sapna Kashyap. Significance of Pharmaceutical Excipients on Solid Dosage form Development: A Brief Review. Asian J. Pharm. Res. 2016; 6(3): 193-202. doi: 10.5958/2231-5691.2016.00028.9
4. Anuja Patil, VJ Kadam, KR Jadhav. Co-processed Pharmaceutical Excipients – A Brief Review. Research J. Pharm. and Tech. 3(1): Jan. - Mar. 2010; Page 50-57.
5. A.Ugbenbo D., Zdoryk O.A., Georgiyants V. Quality assessment and stability study of compounded furosemide syrup, Science Rise Pharmaceutical Science, 9(5) (2017), 28-35, DOI: 10.15587/2519-4852.2017.113517
6. Anjan K. Mahapatra, Ranjit P. Swain, B. Revathi, N. Nirisha, P.N. Murthy. Orodispersible Tablets: A review on Formulation Development Technologies and Strategies. Research J. Pharm. and Tech. 6(9): September 2013; Page 941-953
7. M. Kranthi Kumar Reddy, B. Narasimha Rao, K. Ravindra Reddy. Study on Effect of Excipients in Enhancing the Solubility of Nateglinide by Solid Dispersions . Asian J. Pharm. Res. 2(4): Oct. - Dec. 2012; Page 144-147
8. Romm A., Coven M. (2010) Fundamental principles of Herbal medicine, Botanical medicine for Women Health, Demulcent Agent, Science Direct
9. Sarin.a. Chavhan, Sushilkumar. A. Shinde, Sandip. B. Sapkal , Vinayak N. Shrikhande. Herbal Excipients in Novel Drug Delivery Systems. Asian J. Pharm. Res. 2017; 7(2): 111-117. doi: 10.5958/2231-5691.2017.00019.3
10. Ashok Thulluru, C. Madhavi, K. Nandini, S. Sirisha, D. Spandana. Co-Processed Excipients: New Era in Pharmaceuticals. Asian J. Res. Pharm. Sci. 2019; 9(1):01-05. doi: 10.5958/2231-5659.2019.00001.8
11. Ashwell M. Stevia, Nature's Zero-Calorie Sustainable Sweetener: A New Player in the Fight Against Obesity, Nutrition Today, 50(3) (2015, 129-134. doi: 10.1097/NT.0000000000000094
12. Subhashis Debnath, C. Navya Yadav, N. Nowjiya, M. Prabhavathi, A. SaiKumar, P. Sai Krishna, M. Niranjan Babu. A Review on Natural Binders used in Pharmacy. Asian J. Pharm. Res. 2019; 9(1): 55-60. doi: 10.5958/2231-5691.2019.00009.1
13. Gayathri M, Mithra Chandrasekaran, Arun Radhakrishnan, Gowthamarajan Kuppusamy, Sachin Kumar Singh. Optimizing Badam gum towards tableting excipients. Research J. Pharm. and Tech. 2020; 13(12):6176-6181. doi: 10.5958/0974-360X.2020.01077.X
14. Goyal C., Sharma K.C., Gupta A.K. Stability testing of Ayurvedic Formulations: Exigency of Today’s World, International Journal of Green Pharmacy, 11(3) (2017), S338
15. Patgiri B., Soni H., Bhatt S. Evaluation of stability study of Ayurvedic formulation- Rasayana Churna, Journal of Pharmacognosy and Phytochemistry, 2 (5)( 2014), 126-130
16. ICH Q1A (R2). Stability testing guidelines: Stability testing of new drug substances and products. ICH Steering Committee, 2003
17. A.P.I Part-II (Formulations), Vol-I, Appendix 3.3
18. A.P.I Part-II (Formulations), Vol-I, Appendix 3.1
19. A.P.I Part-II (Formulations), Vol-I, Appendix 3.2
20. Pharmacopoeial Standards for Ayurvedic Formulations, CCRAS, p-495-498, 1987
21. Lachman Lieberman’s The Theory and Practice of Industrial Pharmacy, Chapter- 2, p-61, 2013