Author(s): Sagar N. Ande, Krutika B. Sonone, Ravindrakumar L. Bakal, Prashant V. Ajmire, Harigopal S. Sawarkar

Email(s): sagar986ande@gmail.com

DOI: 10.52711/0974-360X.2022.00811   

Address: Sagar N. Ande*, Krutika B. Sonone, Ravindrakumar L. Bakal, Prashant V. Ajmire, Harigopal S. Sawarkar
Dr. Rajendra Gode Institute of Pharmacy, Amravati, Maharashtra, India – 444602.
*Corresponding Author

Published In:   Volume - 15,      Issue - 10,     Year - 2022


ABSTRACT:
Microemulsions are one in all the most effective candidates as novel drug delivery system due to their long time period stability, improved drug solubilization with simple preparation and administration. Surfactants and cosurfactants play crucial role to get stable, mild and clinically acceptable microemulsions in their optimized concentration, The main aim of the study to produce an efficient screening approach for the surfactant and cosurfactant selection for the excipients of microemulsion formulation development and to check the consequences of surfactant hydrophilic–lipophilic balance (HLB) as well solubilization stability process in microemulsion. The composition and extent of surfactants and cosurfactants were key variables for physicochemical properties of drug-loaded Microemulsions. The important aspects must be considered for a successful microemulsion process is that the stability of the liquid membrane. This study is an attempt to grasp the mechanism of the effect of the surfactant and chain length of co-surfactants within the microemulsion base formulation stability.


Cite this article:
Sagar N. Ande, Krutika B. Sonone, Ravindrakumar L. Bakal, Prashant V. Ajmire, Harigopal S. Sawarkar. Role of Surfactant and Co-surfactant in Microemulsion: A Review. Research Journal of Pharmacy and Technology 2022; 15(10):4829-4. doi: 10.52711/0974-360X.2022.00811

Cite(Electronic):
Sagar N. Ande, Krutika B. Sonone, Ravindrakumar L. Bakal, Prashant V. Ajmire, Harigopal S. Sawarkar. Role of Surfactant and Co-surfactant in Microemulsion: A Review. Research Journal of Pharmacy and Technology 2022; 15(10):4829-4. doi: 10.52711/0974-360X.2022.00811   Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-10-84


REFERENCES:
1.    Lu I-J. Fu Y-S. Chang W-Y. Wu P-C. Using microemulsion as carrier for drug transdermal delivery: The effect of surfactants and cosurfactants. Curr Pharm Des. 2019; 25(10):1052–8. doi.org/10.2174/1381612825666190527091528
2.    Gompper G. Schick M. Phase and scattering behavior of disordered aqueous surfactant solutions as the binary limit of ternary microemulsions. Chem Phys Lett. 1989;163(6):475–9. doi.org/10.1016/0009-2614(89)85171-1
3.    Chennamsetty N. Bock H. Scanu LF. Siperstein FR. Gubbins KE. Cosurfactant and cosolvent effects on surfactant self-assembly in supercritical carbon dioxide. J Chem Phys. 2005;122(9):094710. doi.org/10.1063/1.1855291
4.    Ghosh PK. Murthy RSR. Microemulsions: a potential drug delivery system. Curr Drug Deliv. 2006;3(2):167–80. doi.org/10.2174/156720106776359168
5.    Herrig H. Hempelmann R. Microemulsion mediated synthesis of ternary and quaternary nanoscale mixed oxide ceramic powders. Nanostructured mater . 1997;9(1–8):241–4. doi.org/10.1016/s0965-9773(97)90063-5
6.    Sahoo CK. Rao SRM. Sudhakar M. Hema. Challenges of micro-emulsion as a novel carrier for drug delivery. Res J Pharm Dos Forms Technol. 2019;11(3):227. doi.org/10.5958/0975-4377.2019.00038.7
7.    Jagtap SR. Phadtare DG. Saudagar RB. Microemulsion: A Current Review. Res J Pharm Dos Forms Technol. 2016;8(2):161. doi.org/10.5958/0975-4377.2016.00021.5
8.    Bodkhe AA. Bedi RS. Upadhayay A. Kale MK. Ophthalmic microemulsion: Formulation design and process optimization. Res J Pharm Technol. 2018;11(12):5474. doi.org/10.5958/0974-360x.2018.00998.8
9.    Azeem A. Rizwan M. Ahmad F. Khar R. Iqbal Z. Talegaonkar S. Components screening and influence of surfactant and cosurfactant on nanoemulsion formation. Curr Nanosci. 2009;5(2):220–6. doi.org/10.2174/157341309788185505
10.    Mills AJ. Britton MM. NMR study of the influence of n-alkanol co-surfactants on reverse micelles in quaternary microemulsions of cetyltrimethylammonium bromide (CTAB). Magn Reson Chem. 2017;55(5):425–32. doi.org/10.1002/mrc.4392
11.    Derle DV. Bsh S. Yeole DR. Development and Evaluation of Topical Microemulsion Gels for Protein and Peptide Drug Bacitracin Zinc. Research J Pharma Dosage Forms and Tech. 2009;1(3).
12.    Xiao J. Li W. Study on osmotic pressure of non-ionic and ionic surfactant solutions in the micellar and microemulsion regions. Fluid Phase Equilib. 2008;263(2):231–5. doi.org/10.1016/j.fluid.2007.10.009
13.    Porter MR. Use of surfactant theory. In: Handbook Surfactants . Boston. MA: Springer US; 1991. p. 24–48. doi.org/10.1007/978-1-4615-3676-5_4
14.    Mandavi N. Ansari N. Bharti R. Kader NSA. Sahu GK. Sharma H. Microemulsion: A potential novel drug delivery system. Res J Pharm Dos Forms Technol. 2018;10(4):266. doi.org/10.5958/0975-4377.2018.00039.3
15.    Duangjit S. Chairat W. Opanasopit P. Rojanarata T. Panomsuk S. Ngawhirunpat T. Development. characterization and skin interaction of capsaicin-loaded microemulsion-based nonionic surfactant. Biol Pharm Bull. 2016;39(4):601–10. doi.org/10.1248/bpb.b15-00961
16.    Amiri-Rigi A. Abbasi S. Microemulsion-based lycopene extraction: Effect of surfactants. co-surfactants and pretreatments. Food Chem. 2016;197:1002–7. doi.org/10.1016/j.foodchem.2015.11.077
17.    Polymeric Surfactants and Surfactant-Polymer Interactions. In: Surfactant Science and Technology . Hoboken. NJ. USA: John Wiley and Sons. Inc.; 2005. p. 220–44. doi.org/10.1002/047174607x.ch7
18.    Cullum DC. Surfactant types; classification. identification. separation. In: Introduction to Surfactant Analysis . Dordrecht: Springer Netherlands; 1994. p. 17–41. doi.org/10.1007/978-94-011-1316-8_2
19.    Chandrakar S. Roy A. Sahu R. Phase behavior study of Ciprofloxacin hydrochloride Microemulsion prepared by mixed Nonionic surfactant. Res J Pharm Technol. 2018;11(3):1030. doi.org/10.5958/0974-360x.2018.00192.0
20.    Mundhada DR. Chandewar AV. An Overview on Cationic Surfactant. Res J Pharm Dos Forms Technol. 2015;7(4):294. doi.org/10.5958/0975-4377.2015.00041.5
21.    Sun LH. Liu WD. Sun CL. The adsorption property of wettability reversal surfactant. Adv Mat Res. 2011;233–235:2051–5. doi.org/10.4028/www.scientific.net/amr.233-235.2051
22.    Najjar R. editor. Microemulsions - An Introduction to Properties and Applications . InTech; 2012. doi.org/10.5772/2300
23.    Bhura MRG. Shahiwala A. Poorly water-soluble drugs and formulation strategy to improve oral bioavailability. In: Novel Drug Delivery Technologies. Singapore: Springer Singapore; 2019. p. 11–28. doi.org/10.1007/978-981-13-3642-3_2
24.    Ohadi M. Shahravan A. Dehghannoudeh N. Eslaminejad T. Banat IM. Dehghannoudeh G. Potential use of microbial surfactant in Microemulsion drug delivery system: A systematic review. Drug Des Devel Ther. 2020;14:541–50. doi.org/10.2147/DDDT.S232325
25.    Self-nanoemulsifying drug delivery systems of poorly soluble drug dutasteride: Formulation and in-vitro characterization. J Appl Pharm Sci . 2017; doi.org/10.7324/japs.2017.70402
26.    Matsaridou I. Barmpalexis P. Salis A. Nikolakakis I. The influence of surfactant HLB and oil/surfactant ratio on the formation and properties of self-emulsifying pellets and microemulsion reconstitution. AAPS PharmSciTech . 2012;13(4):1319–30. doi.org/10.1208/s12249-012-9855-7
27.    Microstructures and Rheological Properties of Surfactant Solution. In: Turbulent Drag Reduction by Surfactant Additives . Singapore: John Wiley and Sons Singapore Pte. Ltd.; 2012. p. 183–232. doi.org/10.1002/9781118181096.ch5
28.    Harada Y. Tabuchi M. Dynamic universality in microemulsion system. In: AIP Conference Proceedings. AIP; 1992. doi.org/10.1063/1.42376
29.    Yuan JS. Yip A. Nguyen N. Chu J. Wen X-Y. Acosta EJ. Effect of surfactant concentration on transdermal lidocaine delivery with linker microemulsions. Int J Pharm. 2010;392(1–2):274–84. doi.org/10.1016/j.ijpharm.2010.03.051
30.    Molle B. de Geyer A. Guillermo A. Farago B. Steric interactions in cellular structures formed in a water/oil/surfactant/cosurfactant mixture. Phys Rev Lett. 2003;90(6):068305. doi.org/10.1103/PhysRevLett.90.068305
31.    Kegel WK. Van Aken GA. Bouts MN. Lekkerkerker HNW. Overbeek JTG. De Bruyn PL. Adsorption of sodium dodecyl sulfate and cosurfactant at the planar cyclohexane-brine interface. Validity of the saturation adsorption approximation and effects of the cosurfactant chain length. Langmuir. 1993;9(1):252–6. doi.org/10.1021/la00025a048
32.    Ahmed N. Kermanshahi B. Ghazani SM. Tait K. Tcheng M. Roma A. et al. Avocado-derived polyols for use as novel co-surfactants in low energy self-emulsifying microemulsions. Sci Rep . 2020;10(1):5566. doi.org/10.1038/s41598-020-62334-y
33.    Azeem A. Rizwan M. Ahmad F. Khar R. Iqbal Z. Talegaonkar S. Components screening and influence of surfactant and cosurfactant on nanoemulsion formation. Curr Nanosci . 2009;5(2):220–6. doi.org/10.2174/157341309788185505
34.    W/O microemulsion patented for fabric softener base. Focus On Surfactants. 2004; 2004(2): 5. doi.org/10.1016/s1351-4210(04)00070-8
35.    El’nikova LV. 3D lattice model for the phase transition in a water/oil/surfactant/cosurfactant mixture. In: Solid State Phenomena. Stafa: Trans Tech Publications Ltd.; 2006. p. 315–8. doi.org/10.4028/3-908451-24-8.315
36.    Sunaina. Sethi V. Mehta SK. Ganguli AK. Vaidya S. Understanding the role of co-surfactants in microemulsions on the growth of copper oxalate using SAXS. Phys Chem Chem Phys. 2018;21(1):336–48. doi.org/10.1039/c8cp05622f
37.    Chen J. Ma X-H. Yao G-L. Zhang W-T. Zhao Y. Microemulsion-based anthocyanin systems: effect of surfactants. cosurfactants. and its stability. Int J Food Prop. 2018;21(1):1152–65. doi.org/10.1080/10942912.2018.1485032
38.    Surfactant Associates . Surfactantassociates.com. [cited 2021 Jun 3]. https://www.surfactantassociates.com/resources/solubilization.


Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

1.3
2021CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags


Not Available