Author(s): Surekha D Shetty, K. Laxminarayana Bairy, Mohandas Rao K.G., Naveen Kumar

Email(s): ds.surekha@gmail.com

DOI: 10.52711/0974-360X.2022.00802   

Address: Surekha D Shetty1, K. Laxminarayana Bairy2, Mohandas Rao K.G.1, Naveen Kumar2
1Melaka Manipal Medical College (Manipal Campus), Manipal Academy of Higher Education, Manipal, Karnataka, India.
2Ras Al-Khaimah College of Medical Sciences, RAK Medical & Health Sciences University, Ras AI Khaimah, UAE.
*Corresponding Author

Published In:   Volume - 15,      Issue - 10,     Year - 2022


ABSTRACT:
Background: Drug induced infertility which may be permanent or temporary, is regarded to be a major clinical problem. Sorafenib is a new drug that is being used for advanced renal cell carcinoma and hepatocellular carcinoma. This study aimed to investigate the effect of sorafenib on the histopathology of testes in male mice. Materials and Methods: Thirty animals (9-12 weeks old) were divided into control, positive control and treatment groups. Treatment groups received 25, 50 and 100mg/kg body weight of sorafenib orally for seven consecutive days at intervals of 24 hours between two administrations. Results: Microscopic anatomy of the testes showed sloughing of the germ cells, reduction in the number of sperm cells and variation in the size and shape of the seminiferous tubules. There was no significant change in the diameter of the seminiferous tubules in most of the treated groups except the 5th-week group when compared with control groups. The epithelial height was reduced significantly (P<0.05) in the 4th, 5th and 7th weeks in treated groups compared to that of control groups. Conclusion: The result conforms to the toxic effect of sorafenib in testes of male mice, but this effect is reversible once the drug is withdrawn.


Cite this article:
Surekha D Shetty, K. Laxminarayana Bairy, Mohandas Rao K.G., Naveen Kumar. Study on effect of Sorafenib: With Special Reference to Alterations in Histopathological Parameters in Male Swiss Albino Mice. Research Journal of Pharmacy and Technology 2022; 15(10):4777-2. doi: 10.52711/0974-360X.2022.00802

Cite(Electronic):
Surekha D Shetty, K. Laxminarayana Bairy, Mohandas Rao K.G., Naveen Kumar. Study on effect of Sorafenib: With Special Reference to Alterations in Histopathological Parameters in Male Swiss Albino Mice. Research Journal of Pharmacy and Technology 2022; 15(10):4777-2. doi: 10.52711/0974-360X.2022.00802   Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-10-75


REFERENCES:
1.    Kim J. Kim K. Chung M. Testicular cytotoxicity of DA- 125, a new anthracycline anticancer agent, in rats. Reproductive Toxicology. 1999;13(5):391–397. doi:10.1016/s0890-6238(99)00028-3.
2.    Schilsky RL. Lewis BJ. Sherins RJ. Young RC. Gonadal dysfunction in patients receiving chemotherapy for cancer,” Annals of Internal Medicine. 1980;93(1):109-114. doi: 10.7326/0003-4819-93-1-109.
3.    Berthelsen JG. Testicular cancer and fertility. Int J Androl 1987;10:371-380. doi: 10.1111/j.1365-2605.1987.tb00205.x.
4.    Gandini L. Sgro P. Lombardo F. Paoli D. Culasso F. Toselli L et al. Effect of chemo or radiotherapy on sperm parameters of testicular cancer patients. Hum Reprod. 2006;21:2882–2889. doi: 10.1093/humrep/del167.
5.    Ray A. Shah A. Gudi A. Homburg R. Unexplained infertility: an update and review of practice. Reprod Biomed Online. 2012;24:591–602. doi: 10.1016/j.rbmo.2012.02.021.  
6.    Duffy CM. Allen SM. Clark MA. Discussions regarding reproductive health for young women with breast cancer undergoing chemotherapy. J Clin Oncol. 2005;23:766–773. doi: 10.1200/JCO.2005.01.134.
7.    Begum MR. Ehsan M. Genetic basis of male infertility. AKMMC J. 2013:4(1):37-39. doi:10.3329/akmmcj.v4i1.13683
8.    Brose MS. Frenette CT. Keefe SM. Steind SM. Management of Sorafenib-Related Adverse Events:A Clinician’s Perspective. Semin Onco. 2014;41(2):1-16. Doi:10.1053/j.seminoncol.2014.01.001
9.    Ruppin S. Protzel C. Klebingat KJ. Hakenberg OW. Successful Sorafenib Treatment for Metastatic Renal Cell Carcinoma in a Case with Chronic Renal Failure. Eur Urol. 2009;55:986–988. doi: 10.1016/j.eururo.2008.10.027.
10.    Yu G. Guo Q. Xie L. Liu Y. Wang X. Effects of subchronic exposure to carbendazim on spermatogenesis and fertility in male rats. Toxicol Ind Health. 2009; 25(1):41-47. doi: 10.1177/0748233709103033.
11.    Russell LD. Russell JA. MacGregor GR. Meistrich ML. Linkage of manchette microtubules to the nuclear envelope and observations of the role of the manchette in nuclear shaping during spermiogenesis in rodents. Am J Anat.  1991;192:97–120. doi: 10.1002/aja.1001920202.
12.    Pikulkaew S. Wongasthein D. The effect of DDT congeners on reproductive function in male guppy (Poecilia reticulata). CUMJ. 2006;5(2):219-225.
13.    Oakberg EF. Duration of spermatogenesis in the mouse and timing of the stages of the cycle of the seminiferous epithelium. Am J Anat. 1956;99:507-516. doi: 10.1002/aja.1000990307
14.    Paget GE. Barnes JM. Evaluation of drug activities. In: Lawrence DR and Bacharcach AL (eds.), Pharmacometrics, Academic press, New York. 1964, Pp. 161.  
15.    Narayana K. Prashanthi N. Nayanatara A. Bairy LK. D’Souza UJ. An organophosphate insecticide methyl parathion (O,O-dimethyl O-4-nitrophenyl phosphorothioate) induces cytotoxic damage and tubular atrophy in the testis despite elevated testosterone level in the rat. J Toxicol Sci. 2006;31(3):177–189. DOI: 10.2131/jts.31.177
16.    Prasad AM. Ramnarayan K. Bairy KL. Effect of imatinib on histological parameters in albino mice. J Pharm Sci Rev Res. 2010;4(2):117-122.  
17.    Nakai M. Hess RA. Morphological changes in the rat sertoli cell induced by the microtubule poison carbendazim. Tissue Cell. 1994;26:917-927. doi: 10.1016/0040-8166(94)90041-8.
18.    Narayana K. D`Souza UJ. Prashanthi N. Ganesh K. The antiviral drug ribavirin reversibly affects the reproductive parameters in the male Wistar rat. Folia Morphol. 2005;64(2):65-71.
19.    Lirdi LC. Stumpp T. Sasso-Cerri E. Miraglia SM. Amifostine protective effect on cisplatin-treated rat testis. Anat Rec. 2008;291(7):797-808. doi: 10.1002/ar.20693.
20.    Hesari AK. Shahrooz R. Ahmadi A. Malekinejad H. Saboory E. Crocin prevention of anemia-induced changes in structural and functional parameters of mice testes. Journal of Applied Biomedicine. 2015;13:213-223. doi: 10.1016/j.jab.2015.02.001
21.    Kamarzaman S. Shaban M. Rahman SA.  Effects on Mouse spermatogenesis and DNA fragmentation following exposure to cyclophosphamide and thymoquinone. Eur Int J Sci Technol. 2013;2(7):119.
22.    Sakr S. Mahran HA. Basily NS. Saif ME. Effect of Ginkgo biloba extract on cyclophosphamide induced reproductive toxicity and oxidative stress in male albino mice. World J Pharm Sci. 2015;3(1):16-25.
23.    Kim JM. Ghosh SR. Weil AC. Zirkin BR. Caspase-3 and caspase-activated deoxyribonuclease are associated with testicular germ cell apoptosis resulting from reduced intratesticular testosterone. J Endocrinol. 2001;142:3809-3816. doi: 10.1210/endo.142.9.8375.
24.    Zhao H. Xu S. Wang Z. Li Y. Guo W. Lin C et al. Repetitive exposures to low-dose X-rays attenuate testicular apoptotic cell death in streptozotocin-induced diabetes rats. Toxicol Lett. 2010;192:356-364. doi: 10.1016/j.toxlet.2009.11.011.
25.    Predes FD. Monteiro JC. Matta SLP. Garacia MC. Dolder H. Testicular histomorphometery and ultrastructure of rats treated with cadmium and ginkgo biloba. Biol Trace Elem Res. 2011;140: 330-380. doi: 10.1007/s12011-010-8702-5.
26.    Vidal JD. Whitney KM. Morphologic manifestations of testicular and epididymal toxicity. Spermatogenesis. 2014;4(2):e979099. doi: 10.4161/21565562.2014.979099.
27.    Fadhil MA. AL-Bakri NA. Selman MO. Teratogenic effect of methotrexate on histogenesis of testis in newborn rat. World J Pharm Res. 2016;5(10):79-88.  doi: 10.20959/wjpr201610-7068.
28.    Viveka S. Udyavar A. Shetty B. Kuriakose S. Sudha MJ. Acute effects of gemcitabine on seminiferous tubular histomorphometry in mice model. World J Pharm Pharm Sci. 2014;3(2): 2035-2043. https://www.researchgate.net/publication/264396979.
29.    Yaghmaei P. Parivar K. Gharibi A. Nabiuni M. The biological effects of imatinib on male fertility of wistar rats. Int J Fertil Steril. 2009;3(3):135-142. doi:10.22074/ijfs.2009.45786.
30.    Kumar V. Chakraborty A. Kural MR. Roy P. Alteration of testicular steroidogenesis and histopathology of reproductive system in male rats treated with triclosan. Reprod Toxicol. 2009;27:177-185. doi: 10.1016/j.reprotox.2008.12.002.

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

1.3
2021CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags


Not Available