Author(s): Kamalika Mazumder, Ritu Khanra, Kaushik Biswas, Nripendra N. Bala, Himangshu S. Maji

Email(s): kamalika.payel@gmail.com

DOI: 10.52711/0974-360X.2022.00769   

Address: Kamalika Mazumder1*, Ritu Khanra2, Kaushik Biswas3, Nripendra N. Bala4, Himangshu S. Maji5
1BCDA College of Pharmacy and Technology, Kolkata, West Bengal, 700127.
2Department of Pharmaceutical Technology, JIS University, Kolkata, West Bengal, 700109.
3Department of Pharmaceutical Technology, Eminent College of Pharmaceutical Technology, Kolkata, West Bengal, 700126.
4BCDA College of Pharmacy and Technology, Kolkata, West Bengal, 700127.
5Department of Pharmaceutical Technology, JIS University, Kolkata, West Bengal, 700109.
*Corresponding Author

Published In:   Volume - 15,      Issue - 10,     Year - 2022


ABSTRACT:
Ficus benghalensis L. is a traditional heritage tree available in Indian subcontinent and used traditionally for ailment of several diseases. Present study designed to purify and characterize the bioactive moiety (s) from the aerial root part of the plant, and assessment of the role of extract as well as purified molecules in the prevention of inflammation. Aerial root portion of the plant was first extracted using methanol as solvent, and further fractionated with n-hexane and ethyl acetate. a amyrin acetate (S1) was purified from the n-hexane and ethyl acetate fraction, and stigmasterol (S2), first time purified from the plant using from the ethyl acetate fraction using column chromatography. Extract, purified a-amyrin acetate and stigmasterol were checked for their anti-inflammatory property using Carrageenan induced paw oedema model on rat. Extract at a dose 400 mg/kg, a-amyrin acetate and stigmasterol both at 100 mg /kg dose significantly reduce the inflammation near to normal. After 3 hrs the paw volume was inhibited 25%, 47.5%, 42.5%, 45%, 62.5% by EA extract of 200 mg/kg, 400 mg/kg, stigmasterol 100mg/kg, a- amyrin acetate 100 mg/kg and standard Indomethacin, respectively. The finding of present study revealed the prospective anti-inflammatory property of a-amyrin acetate, stigmasterol and extract of aerial root of Ficus benghalensis L.


Cite this article:
Kamalika Mazumder, Ritu Khanra, Kaushik Biswas, Nripendra N. Bala, Himangshu S. Maji. Exploration of anti-inflammatory activity of extract and isolated compounds obtained from the aerial root of Ficus benghalensis Linn. Research Journal of Pharmacy and Technology 2022; 15(10):4584-8. doi: 10.52711/0974-360X.2022.00769

Cite(Electronic):
Kamalika Mazumder, Ritu Khanra, Kaushik Biswas, Nripendra N. Bala, Himangshu S. Maji. Exploration of anti-inflammatory activity of extract and isolated compounds obtained from the aerial root of Ficus benghalensis Linn. Research Journal of Pharmacy and Technology 2022; 15(10):4584-8. doi: 10.52711/0974-360X.2022.00769   Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-10-42


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