Author(s): Shailendra Singh Narwariya, Suman Jain

Email(s): shailudbs1@gmail.com

DOI: 10.52711/0974-360X.2022.00739   

Address: Shailendra Singh Narwariya, Suman Jain
School of Studies in Pharmaceutical Sciences, Jiwaji University, Gwalior.
*Corresponding Author

Published In:   Volume - 15,      Issue - 10,     Year - 2022


ABSTRACT:
Fenoprofen, a potent nonsteroidal anti-inflammatory drug, is widely used for relief of pain in patients suffering from rheumatic diseases, migraine, sore throat and primary dysmenorrheal. However, this drug has many gastrointestinal side effects produced by its oral administration, such as gastric bleeding and peptic ulcer. These effects were responsible for non-compliance among patients, which ultimately results in treatment failure. The physicochemical properties of Fenoprofen, make it a suitable candidate for transdermal drug delivery, which can overcome the drawbacks of oral administration. In this sense, tablets have been proved to increase the cutaneous absorption of lipophilic drugs when compared to conventional drug delivery systems. The carrageenan test is highly sensitive to nonsteroidal anti-inflammatory drugs and has long been accepted as a useful model to determine the anti-inflammatory effects of natural products. In the present study the anti-inflammatory activity of Fenoprofen and superdisintegrant was investigated by experimental carrageenan animal model. In our study, the induction of carrageenan in the rat hind paw started off the vascular phase of inflammation which was characterized by temporary vasoconstriction and vasodilatation that generated an increase in the size of the edema for all groups.


Cite this article:
Shailendra Singh Narwariya, Suman Jain. Physicochemical In vivo Anti-Inflammatory effect of Tablet containing Fenoprofen. Research Journal of Pharmacy and Technology2022; 15(10):4413-5. doi: 10.52711/0974-360X.2022.00739

Cite(Electronic):
Shailendra Singh Narwariya, Suman Jain. Physicochemical In vivo Anti-Inflammatory effect of Tablet containing Fenoprofen. Research Journal of Pharmacy and Technology2022; 15(10):4413-5. doi: 10.52711/0974-360X.2022.00739   Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-10-12


REFERENCES:
1.    D’souza JI, More HN. Topical Anti-Inflammatory Gels of Fluocinolone Acetonide Entrapped in Eudragit Based Microsponge Delivery System. Research J. Pharm. and Tech. 2008;1(4):502-506. https://rjptonline.org/AbstractView.aspx?PID=2008-1-4-101
2.    Jadhav RP, Kumbhar SB, Kengar MD. Design and In-vitro Evaluation expandable Gastro retentive tablets of Diltiazem Hydrochloride. Asian J. Pharm. Tech. 2020; 10(2):53-59. 10.5958/2231-5713.2020.00011.2  
3.    Nagajyothi M, Pramod K, Bijin EN, Baby JN, Valsalakumari J. Accelerated Stability Studies of Atorvastatin Loaded Nanoemulsion Gel. Asian J. Pharm. Tech. 2015;5(1):188-191. https://ajptonline.com/AbstractView.aspx?PID=2015-5-3-8
4.    Jire DS, Gosavi NS, Badhe RB, Jagdale DH. Mouth Dissolving Tablet: A Novel Drug Delivery System. Asian Journal of Pharmaceutical Research. 2021;11(3):180-6. 10.52711/2231-5691.2021.00033
5.    Kumar P, Usman MRM, Sharma A, Diskha, Mani M, Singh P, et al. Mouth Dissolving Tablets: A Modern Approach to Delivery of Drug. Research J. Pharm. and Tech 2020;13(6):2943-2950. 10.5958/0974-360X.2020.00521.1
6.    Kumbhar DM, Havaldar VD, Mali KK, Dias RJ, Ghorpade VS, Londhe RB. Formulation and Evaluation of Sustained Release Tablets of Venlafaxine Hydrochloride for the treatment of Depressive disorders. Asian J. Pharm. Res. 2017; 7(1): 8-14. 10.5958/2231-5691.2017.00002.8
7.    Mettu SR, Veerareddy PR. Formulation, evaluation and pharmacokinetics of Fenoprofen fast dissolving tablets. Brit J Pharm Res. 2013;3(4):617-31. https://pdfs.semanticscholar.org/7af9/f459a63bd9fbcfc858b270d53ff8af4c83cf.pdf
8.    Nagar P, Singh K, Chauhan I, Verma M, Yasir M, Khan A, et al. Orally disintegrating tablets: formulation, preparation techniques and evaluation. J Appl Pharm Sci. 2011;1(04):35-45. https://japsonline.com/admin/php/uploads/58_pdf.pdf
9.    Neau SH, Howard MA, Clausdius JS, Howard DR. The effect of the aqueous solubility of xanthine derivatives on the release mechanism from ethylcellulose matrix tablets. Int J Pharm. 1999;179(1):97-105. 10.1016/s0378-5173(98)00391-3
10.    Neduri K, Bontha VK, Vemula SK. Different techniques to enhance the dissolution rate of lovastatin: formulation and evaluation. Asian J Pharm Clin Res. 2013;6:(1):56-60. https://www.researchgate.net/publication/284168350_Different_techniques_to_enhance_the_dissolution_rate_of_Lovastatin_Formulation_and_evaluation
11.    Sohail MF, Shah PA, Tariq I, Saeed-ul-Hassan S, Amin U, Raza SA, et al. Development and in vitro evaluation of Fenoprofen microcapsules prepared by modified solvent evaporation technique. Trop J Pharm Res.2014;13(7):1031-8. 10.4314/tjpr.v13i7.4
12.    Valleri M, Mura P, Maestrelli F, Cirri M, Ballerini R. Development and evaluation of glyburide fast dissolving tablets using solid dispersion technique. Drug Develop Ind Pharm. 2004;30(5):525-34. 10.1081/ddc-120037483
13.    Vemula SK, Neduri K. Lovastatin fast dissolving tablets: formulation and in vitro evaluation. App Sci Rep. 2015;11(2):76- 82. 10.15192/PSCP.ASR.2015.11.2.7682)
14.    Vemula SK, Reddy SG. Formulation and pharmacokinetics of Fenoprofen sublimated fast dissolving tablets. Open Pharm Sci J. 2015;2(1):56-65. 10.2174/1874844901502010056
15.    Chaturvedi AK, Verma A. Fast disintegrating tablet technology: newly prospects. International Journal of Pharmaceutical Sciences and Research. 2011 Dec 1;2(12):3046-50. http://dx.doi.org/10.13040/IJPSR.0975-8232.2(12).3046-50

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

1.3
2021CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags


Not Available