Author(s): Madhuri Gaddam, Nagaraju Ravouru

Email(s): Email ID Not Available

DOI: 10.52711/0974-360X.2022.00080   

Address: Madhuri Gaddam1*, Nagaraju Ravouru2
1Department of Pharmaceutics, Rao’s College of Pharmacy, Nellore, Andhra Pradesh, India.
2Institute of Pharmaceutical Technology, Sri Padmavati Mahila Visvavidyalayam, Tirupati- 517502, Andhra Pradesh, India.
*Corresponding Author

Published In:   Volume - 15,      Issue - 1,     Year - 2022


ABSTRACT:
A novel omeprazole co-crystals instant dry suspension dosage was formulated by applying co-crystallization which is a particle engineering technique to enhance the physicochemical properties. As omeprazole has major critical draw backs in their solubility and stability (acidic pH degradation, thermal sensitivity, photosensitivity and highly hygroscopic nature) bioavailability of omeprazole was drastically reduced and purpose of administration of drug was not fulfilled. There by this formulation was invented to check maid these problems. In this present study in-vivo evaluation were performed. Pharmacokinetic parameters and pharmacodynamic parameters were determined and statistically analysed. The prepared formulation of omeprazole produced reliable satisfaction in solving the drawback problems of pure omeprazole by enhancing bioavailability. Statistical analysis was done by one way ANOVA test with P value less than 0.0001, Dunnet multiple comparison test was performed between the groups with P value < 0.01 which was considered to be significant.


Cite this article:
Madhuri Gaddam, Nagaraju Ravouru. Pharmacokinetic and Pharmacodynamic studies of Omeprazole Co-crystals dry suspension. Research Journal of Pharmacy and Technology. 2022; 15(1):494-8. doi: 10.52711/0974-360X.2022.00080

Cite(Electronic):
Madhuri Gaddam, Nagaraju Ravouru. Pharmacokinetic and Pharmacodynamic studies of Omeprazole Co-crystals dry suspension. Research Journal of Pharmacy and Technology. 2022; 15(1):494-8. doi: 10.52711/0974-360X.2022.00080   Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-1-80


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