Author(s): Tarun Kumar Satpathy, Neelesh Chaubey, Chandan Kumar Brahma, Mittal Maheshwari

Email(s): tarun.satpathy@gmail.com

DOI: 10.52711/0974-360X.2022.00038   

Address: Tarun Kumar Satpathy1*, Neelesh Chaubey1, Chandan Kumar Brahma2, Mittal Maheshwari3
1College of pharmacy, Sri Satya Sai University of Technology and Medical Sciences, Sehore MP, India.
2 Department of Pharmaceutical Technology, KJR College of Pharmacy, Rajahmundry, A.P., India.
3A-One Pharmacy College, SNME Campus, Ahmedabad, Gujarat, India.
*Corresponding Author

Published In:   Volume - 15,      Issue - 1,     Year - 2022


ABSTRACT:
The main purpose of this investigation study is to fabricate nanosponges with good entrapment efficiency and percentage of yield to enhance the solubility and dissolution rate of poorly water soluble antiepileptic molecules of Lamotrigine, which belongs to BCS - II class. Lamotrigine nanosponges were prepared using emulsion solvent diffusion technique and the immediate release tablets of lamotrigine nanosponges were prepared by direct compression method. Nanosponges were formulated using different polymers ratio like EC and PVA. The optimized batch containing ratio 2:1:2 of drug, ethyl cellulose and PVA shows maximum entrapment efficiency and percentage of yield. The optimized nanosponges of lamotrigine (F1) were subjected for Practical yield, drug content, Saturation solubility, zeta potential, Fourier transform Infrared spectroscopy (FTIR), Differential Scanning Calorimetry (DSC) and Scanning electron microscopy(SEM). The optimized formulations (F1) of nanosponge based immediate release tablets compression parameters were also studied. The In-vitro dissolution was carried out by USP apparatus type II (Paddle Method) with 900 ml of 0.1 N HCl at 50 rpm. At definite time intervals, 5 ml of the receptor fluid were withdrawn, filtered and analyzed spectro-photometrically at wave length 265 nm. The compressed lamotrigine nanosponge shows 99.7% at the end of dissolution and it follows first order kinetics and best fit with Higuchi’s model. In this research solubility and dissolution demonstrated for nanosponge formulation.


Cite this article:
Tarun Kumar Satpathy, Neelesh Chaubey, Chandan Kumar Brahma, Mittal Maheshwari. Formulation and Evaluation of Lamotrigine Loaded Nanosponges. Research Journal of Pharmacy and Technology. 2022; 15(1):229-5. doi: 10.52711/0974-360X.2022.00038

Cite(Electronic):
Tarun Kumar Satpathy, Neelesh Chaubey, Chandan Kumar Brahma, Mittal Maheshwari. Formulation and Evaluation of Lamotrigine Loaded Nanosponges. Research Journal of Pharmacy and Technology. 2022; 15(1):229-5. doi: 10.52711/0974-360X.2022.00038   Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-1-38


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