Author(s):
Chetan Savant, Venkatrao Kulkarni, Prasanna Habbu, Preeti Kulkarni, Muhammed Majeed, Mahadeva Nayak
Email(s):
chetan.savant@yahoo.com
DOI:
10.52711/0974-360X.2022.00030 
Address:
Chetan Savant1*, Venkatrao Kulkarni1, Prasanna Habbu2, Preeti Kulkarni1, Muhammed Majeed3, Mahadeva Nayak3.
1Department of Pharmacology, SET’s College of Pharmacy, Dharwad-580002, Karnataka, India.
2Department of Pharmacognosy, SET’s College of Pharmacy, Dharwad- 580002, Karnataka, India.
3SAMI Labs Limited, R&D Peenya Industrial Area, Bangalore- 560058, Karnataka, India.
*Corresponding Author
Published In:
Volume - 15,
Issue - 1,
Year - 2022
ABSTRACT:
The present experiment was carried out with the aim to screen selected herb-drug for its antioxidant activity in combination and individually. The antioxidant activity of test samples were estimated by 2,2 Diphenyl -1-picryl hydrazyl (DPPH) radical scavenging activity, hydroxyl radical scavenging activity, reducing power assay. All the selected herb-drug combinations have shown significant antioxidant activity in all three antioxidant procedures compared to individual herb or drug sample. Hence, it may be concluded that herb-drug combinations have better antioxidant potential than alone.
Cite this article:
Chetan Savant, Venkatrao Kulkarni, Prasanna Habbu, Preeti Kulkarni, Muhammed Majeed, Mahadeva Nayak. Screening of Novel Hybrid Combinations of Synthetic Drugs with Plant Extracts for its In vitro Antioxidant Activity. Research Journal of Pharmacy and Technology. 2022; 15(1):188-2. doi: 10.52711/0974-360X.2022.00030
Cite(Electronic):
Chetan Savant, Venkatrao Kulkarni, Prasanna Habbu, Preeti Kulkarni, Muhammed Majeed, Mahadeva Nayak. Screening of Novel Hybrid Combinations of Synthetic Drugs with Plant Extracts for its In vitro Antioxidant Activity. Research Journal of Pharmacy and Technology. 2022; 15(1):188-2. doi: 10.52711/0974-360X.2022.00030 Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-1-30
REFERENCES:
1. Valko M et al. Free radicals and antioxidants in normal physiological functions and human disease. International Journal of Biochemistry and Cell Biology. 2007; 39: 44‐84.
2. Devasagayam TP et al. Free radicals and antioxidants in human health: current status and future prospects. Journal of the Association of Physicians of India. 2004; 52: 794-804.
3. Park PJ et al. Purification and characterization of antioxidative peptides from protein hydrolysate of lecithin free egg yolk. Journal of the American Oil Chemists' Society. 2001;78: 651‐656.
4. Jain A et al. Phytochemical composition and antioxidant activity of methanolic extract of Ficus benjamina (moraceae) leaves. Research Journal of Pharmacy and Technology. 2013; 6(11): 1184-1189.
5. Wiysonge CS et al. Beta-blockers for hypertension. Cochrane database of systematic reviews. 2017(1).
6. Kumaraswamy G et al. Development and Validation of a Reversed-Phase HPLC Method For Simultaneous Determination of Aspirin, Atenolol and Amlodipine in Capsules Dosage Forms. Asian Journal of Pharmaceutical Analysis. 2014; 4(3): 116-120.
7. Muthukumaran P et al. In vitro Antioxidant Activity of Premna serratifolia Linn. Asian Journal of Research in Pharmaceutical Sciences. 2013; 3(1): 15-18
8. Subhrajyoti Roy et al. Assessment of the Antioxidant and Free Radical Scavenging Activities of Methanolic Extract of Diplazium esculentum. International Journal of Food Properties. 2013; 16(6): 1351-1370.
9. Patel DS et al. Evaluation of In-vitro Anti-oxidant and Free Radical Scavenging activities of Withania somnifera and Aloe vera. Asian Journal of Pharmacy and Technology. 2012; 2(4): 143-147.
10. Rao KV et al. Phytochemical composition, antioxidant, antimicrobial and cytotoxic potential of methanolic extracts of Adhatoda vasica (Acanthaceae). Research Journal of Pharmacy and technology. 2013; 6(9): 1004-1009.
11. Ghanshyam B et al. Free radical Scavenging and Antioxidant Activity of Punica granatum Linn. Asian Journal of Research in Pharmaceutical Sciences. 2014; 4(2): 51-54.
12. Devasagayam TPA, Baloor KK, Mishra KP. Some new methods for free radical research. SFRR-India Bulletin. 2003; 2(2): 20-28.
13. Dixit P et al. Antioxidant properties of germinated fenugreek seeds. Phytotherapy Research 19; 2005: 977-983.
14. Chatterjee S et al. A modified, economic, sensitive method for measuring total antioxidant capacities of human plasma and natural compounds using Indian saffron (Crocus sativus). Clinica Chimica Acta. 2005; 352(1-2): 155-163.
15. Shirwaikar A et al. In vitro antioxidant studies of Sphaeranthus indicus (Linn). Indian Journal of Experimental Biology. 2006; 44: 993-996.
16. Mosquera OM et al. Antioxidant activity of twenty five plants from Colombian biodiversity. Memorias do Instituto Oswaldo Cruz. 2007; 102(5): 631-634.
17. Villaño D et al. Radical scavenging ability of polyphenolic compounds towards DPPH free radical. Talanta. 2007; 71(1): 230-235.
18. Kondragunta K et al. Antioxidant activity and Folic acid content in indigenous isolates of Ganoderma lucidum. Asian Journal of Pharmaceutical Analysis. 2016; 6(4): 213-215.
19. Foti MC et al. Electron-transfer reaction of cinnamic acids and their methyl esters with the DPPH• radical in alcoholic solutions. Journal of Organic Chemistry. 2004; 69(7): 2309-2314.
20. Gutteridge MC et al. Reactivity of hydroxyl and hydroxyl‐like radicals discriminated by release of thiobarbituric acid reactive material from deoxy sugars, nucleosides and benzoate. Biochemical Journal. 1984; 224: 761−767.
21. Spencer JPE et al. Intense oxidative DNA damage promoted by L‐DOPA and its metabolites, implications for neurodegenerative disease. FEBS Letters. 1994; 353(3): 246‐250.
22. Malathi R et al. Antioxidant Activity of Extract from the Leaves of Tylophora asthmatica. Asian Journal of Research in Pharmaceutical Sciences. 2012; 2(2): 80-82.
23. Geckil H et al. Antioxidant, free radical scavenging and metal chelating characteristics of propolis. American Journal of Biochemistry and Biotechnology. 2005; 1(1): 27–31.
24. Sheela S et al. Free Radical Scavenging Activity of Leaves of Memecylon edule Roxb. Research Journal of Pharmacognosy and Phytochemistry. 2009; 1(2): 109-112.
25. Matsusighe K et al. Potent free radical scavenging activity of dicaffeoyl quinic acid derivatives from propolis. Journal of Traditional Medicine. 1996; 13: 217–228.
26. Jain DP et al. Synergistic antioxidant activity of green tea with some herbs. Journal of advanced pharmaceutical technology and research. 2011; 2(3):177.
27. Yang WJ et al. Synergistic antioxidant activities of eight traditional Chinese herb pairs. Biological and Pharmaceutical Bulletin. 2009; 32(6):1021-1026.