Sani Ega Priani, Emalia Nurhasanah, Anan Suparman
Sani Ega Priani*, Emalia Nurhasanah, Anan Suparman
Department of Pharmacy, Bandung Islamic University (UNISBA), Bandung 40116, West Java, Indonesia.
Volume - 15,
Issue - 1,
Year - 2022
Acne is the most common skin problem which can occur due to a bacterial infection. Cinnamon bark oil contains cinnamaldehyde and other active compounds which have antibacterial activity. Olive oil is also known to have antibacterial activity and can reduce skin irritation from cinnamon bark oil application. The nanogel system is known to be suitable for the delivery of active compounds to treat acne. This research aims to develop nanogel preparations containing cinnamon bark oil and olive oil and characterize the gels' physical properties and antibacterial activity against Propionibacterium acnes. The antibacterial activity test of cinnamon bark oil and preparations were carried out by the diffusion method using the perforation technique. Nanogels were prepared using tween 80 as a surfactant, PEG 400 as a co-surfactant, and Viscolam as a gelling agent. The nanogels were characterized by organoleptic, pH, viscosity, spreadability, percent transmittance, globule size diameter, and stability tests. The result showed that cinnamon bark oil has antibacterial activity against Propionibacterium acnes with a MIC value of 0.2%. Nanogel preparations containing cinnamon bark oil (2; 3; and 4%) and olive oil (2%) have good physical characteristics and stability with a clear appearance with an average globule size 129 ±17 nm; 132 ± 18 nm; and 135 ± 19 nm, respectively. Nanogel preparations have potent antibacterial activity against Propionibacterium acnes. The antibacterial activity of the gels depends on oil concentration.
Cite this article:
Sani Ega Priani, Emalia Nurhasanah, Anan Suparman. Development of Antiacne Nanogel containing Cinnamon Bark Oil (Cinnamomum burmannii Nees ex Bl.) and Olive Oil (Olea europaea L.). Research Journal of Pharmacy and Technology. 2022; 15(1):143-7. doi: 10.52711/0974-360X.2022.00023
Sani Ega Priani, Emalia Nurhasanah, Anan Suparman. Development of Antiacne Nanogel containing Cinnamon Bark Oil (Cinnamomum burmannii Nees ex Bl.) and Olive Oil (Olea europaea L.). Research Journal of Pharmacy and Technology. 2022; 15(1):143-7. doi: 10.52711/0974-360X.2022.00023 Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-1-23
1. Masterson KN. Acne Basics: Pathophysiology, Assessment, and Standard Treatment Options. J Dermatology Nurses' Assoc. 2018; 10: 2-10.
2. Kadam Trupti V., Waghmare Sneha S., Darekar A.B., Saudagar R.B. An Overview: Acne Vulgaris.Res. J. Pharm. Dosage Form. & Tech. 2015'; 7(2): 156-160.
3. Fitz-Gibbon S, Tomida S, Chiu BH, Nguyen L, Du C, Liu M, et al. Propionibacterium acnes strain populations in the human skin microbiome associated with acne. J Invest Dermatol. 2013; 133(9):2152-60.
4. Contassot E, French LE. New insights into acne pathogenesis: Propionibacterium acnes activates the inflammasome. Journal of Investigative Dermatology. 2014; 134(2): 310-313.
5. K. Kameswararao, Ch. Sujani, N.V.N Koteswararao, A.Rajarao, P.N.S. Satyanarayanamma. A Brief Review on Acne Vulgaris. Res. J. Pharmacology and Pharmacodynamics. 2019; 11(3):109-119.
6. Menggala SR, Damme P V. Improving Indonesian cinnamon (c. burmannii (Nees & t. nees) Blume) value chains for Greater Farmers Incomes. In: IOP Conference Series: Earth and Environmental Science. 2018; 129: 1-6.
7. Sandhya S, Vidhya Sravanthi E, David Banji, Rajeswar T. A Review on Medicinal Herbs Used for Acne. Res. J. Topical and Cosmetic Sci. 2011; 2(2): 40-44.
8. Daud FS, Pande G, Joshi M, Pathak R, Wankhede S. A study of antibacterial effect of some selected essential oils and medicinal herbs against acne causing bacteria. Int J Pharm Sci Invent. 2013; 2(1): .27-34.
9. Gill AO, Holley RA. Mechanisms of bactericidal action of cinnamaldehyde against Listeria monocytogenes and of eugenol against L. monocytogenes and Lactobacillus sakei. Appl Environ Microbiol. 2004; 70(10): 5750–5755.
10. Rashmi Tamanekar, Shamika Salavkar, Rajani Athawale. Pilosebaceous Targeting – An Emerging Concept in Topical and Cosmetic Science. Res. J. Topical and Cosmetic Sci. 2011; 2(2): 45-51.
11. Saurabh Tiwari, Shweta Singh, Pushpendra Kumar Tripathi, Chetan Kumar Dubey. Transdermal Drug Therapy- A Novel Approach for Acne Vulgaris Treatment. Research J. Topical and Cosmetic Sci. 2016; 7(1): 23-26.
12. Vyas A, Kumar Sonker A, Gidwani B. Carrier-based drug delivery system for treatment of acne. The Scientific World Journal. 2014; 2014: 1-14.
13. Pooja Shivane, Sridevi G., Gopkumar P., Sujit Pillai. Formulation and Evaluation of Sustain Release Microsphere of Tretinoin for the Treatment of Acne vulgarise. Research J. Pharm. and Tech. 2013; 6(10): 1089-1093.
14. Surekha Baghel, Bina Gidwani, Chanchal Deep Kaur. Novel Drug Delivery Systems of Herbal Constituents Used in Acne. Asian J. Res. Pharm. Sci. 2017; 7(2): 57-67.
15. Pathan B, Pathan IB, Dwivedi R, Ambekar W. Formulation and evaluation of ketoprofen loaded chitosan nanogel for pain management: Ex-vivo and In-vivo study. Ars Pharm. 2019; 60(2): 101-108.
16. Saurabh Tiwari, Shweta Singh, Pushpendra Kumar Tripathi, Chetan Kumar Dubey. A Review- Nanogel Drug Delivery System. Asian J. Res. Pharm. Sci. 2015; 5(4): 253-255.
17. Jaiswal M, Dudhe R, Sharma PK. Nanoemulsion: an advanced mode of drug delivery system. 3 Biotech. 2015; 5(2): 123–127.
18. Azmi NAN, Elgharbawy AAM, Motlagh SR, Samsudin N, Salleh HM. Nanoemulsions: Factory for food, pharmaceutical and cosmetics. Processes. 2019; 7(9), 617-623.
19. Najafi-Taher R, Amani A. Nanoemulsions: Colloidal topical delivery systems for antiacne agents- A Mini-Review. Nanomedicine Research Journal. 2017; 2(1) : 49-56.
20. Phatak Atul A., Chaudhari Praveen D. Development and Evaluation of Nanogel as a Carrier for Transdermal Delivery of Aceclofenac. Asian J. Pharm. Tech. 2012; 2(4): 125-132.
21. Connolly M, Axtell A, Hickey S, Whalen A, McNamara L, Albright D, et al. Chemical Burn From Cinnamon Oil. Eplasty. 2017; 17: 1-6.
22. Nazzaro F, Fratianni F, Cozzolino R, Martignetti A, Malorni L, Feo V De, et al. Antibacterial activity of three extra virgin olive oils of the campania region, southern italy, related to their polyphenol content and composition. Microorganisms. 2019; 7(9): 321-328.
23. Lin TK, Zhong L, Santiago JL. Anti-inflammatory and skin barrier repair effects of topical application of some plant oils. International Journal of Molecular Sciences. 2018; 19(1): 70-76.
24. Harshitha C, Karthikeyan Murthykumar, Anupama Deepak, Dhanraj. Beneficial Effects of Olive Oil on Human Health - A Review. Research J. Pharm. and Tech. 2016; 9(5): 593-595
25. Sefidkon F, Jalili A, Mirhaji T. Essential oil composition of three Artemisia spp. from Iran. Flavour Fragr J. 2002; 17(2): 150-152.
26. Priani SE, Azhari Abdilla S, Suparnan A. Pengembangan sediaan mikroemulsi gel antijerawat mengandung minyak kulit batang kayu manis (Cinnamomum burmanni Nees ex Bl). J Ilm Farm Farmasyifa. 2020; 3(1): 9-17.
27. E M, MI B, CC G. Method to Produce Curcumin Oil-in-Water Nanoemulsions as Templates for Drug Carriers. J Biotechnol Biomater. 2016; 6(4): 247-250.
28. Baboota S, Shakeel F, Ahuja A, Ali J, Shafiq S. Design, development and evaluation of novel nanoemulsion formulations for transdermal potential of celecoxib. Acta Pharm. 2007; 57(3):315-32.
29. Ali MS, Alam MS, Alam N, Siddiqui MR. Preparation, characterization and stability study of dutasteride loaded nanoemulsion for treatment of benign prostatic hypertrophy. Iran J Pharm Res. 2014; 13(4): 1125–1140.
30. Mustarichie R, Sulistyaningsih S, Runadi D. Antibacterial Activity Test of Extracts and Fractions of Cassava Leaves (Manihot esculenta Crantz) against Clinical Isolates of Staphylococcus epidermidis and Propionibacterium acnes Causing acne. Int J Microbiol. 2020; 2020 : 1-9.
31. Fajar A, Ammar GA, Hamzah M, Manurung R, Abduh MY. Effect of tree age on the yield , productivity, and chemical composition of essential oil from Cinnamomum burmannii. Curr Res Biosci Biotechnol. 2019; 1: 17-22.
32. Eduardo L de, Farias T, Silva G, Lopes FP da, Ferreira S. Antibacterial Potential Of The Alpha-pinene Positive Enantiomer Against The Strain Proteus mirabilis. Moltonet. 2017; 3: 1-6.
33. Veerasophon J, Sripalakit P, Saraphanchotiwitthaya A. Formulation of anti-acne concealer containing cinnamon oil with antimicrobial activity against Propionibacterium acnes. J Adv Pharm Technol Res. 2020; 11(2): 53–58.
34. Nowotarska S, Nowotarski K, Grant I, Elliott C, Friedman M, Situ C. Mechanisms of Antimicrobial Action of Cinnamon and Oregano Oils, Cinnamaldehyde, Carvacrol, 2,5-Dihydroxybenzaldehyde, and 2-Hydroxy-5-Methoxybenzaldehyde against Mycobacterium avium subsp. paratuberculosis (Map). Foods. 2017; 6(9):72-76.
35. Kumar N, Mandal A. Surfactant Stabilized Oil-in-Water Nanoemulsion: Stability, Interfacial Tension, and Rheology Study for Enhanced Oil Recovery Application. Energy and Fuels. 2018; 32(6) : 6452–6466.
36. Kumar M, Bishnoi RS, Shukla AK, Jain CP. Techniques for Formulation of Nanoemulsion Drug Delivery System: A Review. Prev Nutr Food Sci. 2019; 24(3): 225-234.