Author(s): Harendra Pratap, Manish Kumar Shakya, Talever Singh, Mohit Agrawal, Nishant Singh Katiyar

Email(s): harendrapratap1996@gmail.com

DOI: 10.52711/0974-360X.2022.00014   

Address: Harendra Pratap1*, Manish Kumar Shakya1, Talever Singh1, Mohit Agrawal1, Nishant Singh Katiyar2
1Department of Pharmacology, Rajiv Academy for Pharmacy, N.H-2, P.O. Chhatikara, Mathura, (U.P), India.
2Faculty of Pharmaceutical Sciences, Rama University, Kanpur, (U.P), India.
*Corresponding Author

Published In:   Volume - 15,      Issue - 1,     Year - 2022


ABSTRACT:
Background: Holoptelea integrifolia has been used for a long time in traditional medicine to cure inflammatory pain. The goal of the current research was to consider the anti-inflammatory activity and phytochemicals study of both the extracts of the stem bark of Holoptelea integrifolia. Methods: Anti-inflammatory potential was figure out in Carrageenan and Histamine models at 200 mg/kg doses. Apart from this, we have evaluated parameters like paw edema body weight, locomotor activity, hematological, biochemical assessment, etc. Results: Qualitative chemical test investigation of both the extracts of H. integrifolia stem bark acknowledge the presence of proteins, amino acids, alkaloids, glycosides, tannins, and flavenoids. The 200 mg/kg, p.o dose of the extract showed remarked (P < 0.05) dose-dependent inhibition of edema formation. Both the ethanolic extract (200 mg/ kg, b. w) and aqueous extract (200 mg/ kg, b. w) of H. integrifolia stem bark showed remarked anti-inflammatory properties in comparison to reference drug Ibuprofen. In the Carrageenan model, the ethanolic extract has good anti-inflammatory activity than the aqueous extract. So, the ethanolic extract of stem bark of H. integrifolia is used to combat inflammation alone or with other conventional anti-inflammatory agents to treat different inflammatory disorders. Conclusion: Taken together, these results support the traditional use of Holoptelea integrifolia as a potent anti-inflammatory agent that may be proposed for the treatment of inflammatory pain.


Cite this article:
Harendra Pratap, Manish Kumar Shakya, Talever Singh, Mohit Agrawal, Nishant Singh Katiyar. A Study on Anti-inflammatory Activity of Stem Bark Extract of Holoptelea integrifolia. Research Journal of Pharmacy and Technology. 2022; 15(1):77-1. doi: 10.52711/0974-360X.2022.00014

Cite(Electronic):
Harendra Pratap, Manish Kumar Shakya, Talever Singh, Mohit Agrawal, Nishant Singh Katiyar. A Study on Anti-inflammatory Activity of Stem Bark Extract of Holoptelea integrifolia. Research Journal of Pharmacy and Technology. 2022; 15(1):77-1. doi: 10.52711/0974-360X.2022.00014   Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-1-14


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