Author(s): Swarupananda Mukherjee, Saumyakanti Giri, Sohini Bera, Sharanya Mukherjee, Shankha Dey, Niladri Sekhar Roy

Email(s): Swarupananda.mukherjee@nshm.com , swarup_mukherjee@rediffmail.com

DOI: 10.52711/0974-360X.2021.00880   

Address: Swarupananda Mukherjee*, Saumyakanti Giri, Sohini Bera, Sharanya Mukherjee, Shankha Dey, Niladri Sekhar Roy
NSHM Knowledge Campus Kolkata – Group of Institutions, Department of Pharmaceutical Technology, 124, B L Saha Road, Kolkata – 700053.
*Corresponding Author

Published In:   Volume - 14,      Issue - 9,     Year - 2021


ABSTRACT:
The protein degradation is a well-controlled, highly selective mechanism for intracellular protein degradation and its turnover. There are several proteins in our body but among them some goes for degradation at a time. Proteins which are going to be degraded are identified by a 76 amino acid polypeptide known as ubiquitin and the process is known as ubiquitination. Ubiquitation means the attachment of many ubiquitin molecules to the target protein molecule that need to be broken down. During the ubiquitination procedure iso peptide bonds are formed. And these iso peptide bonds are formed between the nitrogen molecule of the lysine residue from the target protein and the carbon molecule of the ubiquitin molecule. Through this endogenous ubiquitin-proteasome machinery, disease responsible proteins can be permanently removed. Energy is required for this process and that’s why ATP is employed in this process. This targeted protein degradation plays a very crucial role for cancer and other diseases. Through this review we just enlighten the significant points if the targeted protein degradation and its significance.


Cite this article:
Swarupananda Mukherjee, Saumyakanti Giri, Sohini Bera, Sharanya Mukherjee, Shankha Dey, Niladri Sekhar Roy. Targeted Protein Degradation: Current Status and Future Prospects. Research Journal of Pharmacy and Technology. 2021; 14(9):5047-0. doi: 10.52711/0974-360X.2021.00880

Cite(Electronic):
Swarupananda Mukherjee, Saumyakanti Giri, Sohini Bera, Sharanya Mukherjee, Shankha Dey, Niladri Sekhar Roy. Targeted Protein Degradation: Current Status and Future Prospects. Research Journal of Pharmacy and Technology. 2021; 14(9):5047-0. doi: 10.52711/0974-360X.2021.00880   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-9-94


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