Author(s): Ban Jasim Mohamad, Faeza Aftan Zghair

Email(s): ban.jasim@sc.uobaghdad.edu.iq , faizarawi@yahoo.co.uk

DOI: 10.52711/0974-360X.2021.00874   

Address: Ban Jasim Mohamad1, Faeza Aftan Zghair2
1Biology Department, College of Science, University of Baghdad. Baghdad, Iraq.
2Department of Pathology and Forensic Medicine, College of Medicine, Al-Iraqia University, Baghdad, Iraq.
*Corresponding Author

Published In:   Volume - 14,      Issue - 9,     Year - 2021


ABSTRACT:
Pseudoephedrine (PSE) or (Sudafed) is one of the sympathomimetic group of drugs (ephedrine, PSE and amphetamines) which effects cardiovascular system, respiratory system, and gastrointestinal tract. However, only little researches had supported its effect on solid abdominal organs. This study aims to investigate the effects of different doses of Sudafed in the liver and kidney of albino mice. The current study included 18 albino mice grouped into 2 groups: control (3 mice), and acute group (15 mice). The acute group was further subdivided into 5 subgroups, each subgroup of 3mice wasgiven a lonely intaperitonial injection of 0.3ml of the following conc. (500mg/kg, 250mg/kg, 125mg/kg, 62.52mg/kg, and 31.24mg/kg) for 24hrs. After the mentioned period, the mice of all subgroups were sacrificed and the livers and kidneys were removed, processed, sectioned and stained for histological analysis. Results of liver analysis using 500mg/Kg Sudafed intraperitoneallyshowed mild ballooning degeneration of hepatocytes and central vein congestion, while lower doses (250mg/Kg – 31.42mg/Kg) revealed less prominent effect or no significant pathological changes.Moreover, sections from the kidney with the 500mg/Kg Sudafed intraperitoneally showed mild hydropic swelling of tubular epithelium with congestion of intertubular blood vessels and relatively healthy glomeruli. Lower doses revealed no significant pathological changes. Conclusion: The present study demonstrated various pathological effects of PSE on kinetic activity, and histology of Livers and Kidneys of albino mice.


Cite this article:
Ban Jasim Mohamad, Faeza Aftan Zghair. The Effect of Pseudoephedrine (Sudafed) on Kinetic activity and histology of Livers and Kidneys in Albino Mice. Research Journal of Pharmacy and Technology. 2021; 14(9):5015-8. doi: 10.52711/0974-360X.2021.00874

Cite(Electronic):
Ban Jasim Mohamad, Faeza Aftan Zghair. The Effect of Pseudoephedrine (Sudafed) on Kinetic activity and histology of Livers and Kidneys in Albino Mice. Research Journal of Pharmacy and Technology. 2021; 14(9):5015-8. doi: 10.52711/0974-360X.2021.00874   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-9-88


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