Author(s): Gajanand Nangare, Varsha Tegeli, Suyash Ingle, Vinod Matole, Avinash Birajdar, Sagar Adlinge

Email(s): gajanandnangare0607@gmail.com

DOI: 10.52711/0974-360X.2021.00872   

Address: Gajanand Nangare*, Dr. Varsha Tegeli, Suyash Ingle, Vinod Matole, Avinash Birajdar, Sagar Adlinge
D.S.T.S. Mandal’s College of Pharmacy, Solapur - 413004 Maharashtra, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 9,     Year - 2021


ABSTRACT:
Objectives: A new, economical, sensitive, simple, rapid UV spectrophotometric method has been developed for the estimation of Dapsone in pure form and Semisolid Dosage form. Method: This UV method was developed using methanol: RO water (75:25) as a solvent. In the present method the wavelength selected for analysis was 260nm. UV-Visible double beam spectrophotometer (Systronic 2201) was used to carry out spectral analysis. The ICH guidelines were used to validate the method. Results: The method was validated for linearity, range, accuracy, precision, robustness, LOD and LOQ. Linearity was found in the range of 3-18µg/ml. Accuracy was performed by using recovery study. The amount of drug recovered was found to be in the range of 100.1-100.5 %. The %RSD value was found to be less than 2. Conclusion: The proposed UV spectroscopic method was found to be accurate, precise, stable, linear, specific, and simple for quantitative estimation of Dapsone in bulk and Semisolid dosage form. Hence the present UV spectroscopic method is suitable for routine assay of Dapsone in bulk and Semisolid dosage form.


Cite this article:
Gajanand Nangare, Varsha Tegeli, Suyash Ingle, Vinod Matole, Avinash Birajdar, Sagar Adlinge. UV Spectrophotometric Analysis and Validation of Dapsone in Semisolid Dosage Form. Research Journal of Pharmacy and Technology. 2021; 14(9):5007-9. doi: 10.52711/0974-360X.2021.00872

Cite(Electronic):
Gajanand Nangare, Varsha Tegeli, Suyash Ingle, Vinod Matole, Avinash Birajdar, Sagar Adlinge. UV Spectrophotometric Analysis and Validation of Dapsone in Semisolid Dosage Form. Research Journal of Pharmacy and Technology. 2021; 14(9):5007-9. doi: 10.52711/0974-360X.2021.00872   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-9-86


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