Author(s): Amrita Muralikrishnan, Radhika R Nair, Jifitha Banu, Leena K Pappachen

Email(s): leenakpappachen@aims.amrita.edu

DOI: 10.52711/0974-360X.2021.00867   

Address: Amrita Muralikrishnan, Radhika R Nair, Jifitha Banu, Dr Leena K Pappachen
Department of Pharmaceutical Chemistry and Analysis, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, Kerala, India.
*Corresponding Author

Published In:   Volume - 14,      Issue - 9,     Year - 2021


ABSTRACT:
Fungus is a kind of living organism and yeast mould and mushrooms are types of fungi. The fungal infections are caused by the fungus. A fungus that invades the tissue can cause a disease that confined to the skin, spread into tissue, bone and organs or affect the whole body. Benzimidazole is a class of heterocyclic aromatic organic compound which posses pharmacological activities including antifungal, antitumor, antiparasitic, analgesic etc. Insilico methods can be used to identify target molecules using bioinformatics tool. The aim of our study was to conduct the insilico drug designing of some benzimidazole derivatives having antifungal activities. In our study the insilico drug design was performed using Biovia discovery studio.


Cite this article:
Amrita Muralikrishnan, Radhika R Nair, Jifitha Banu, Leena K Pappachen. In silico designing of some Benzimidazole derivatives for Anti-fungal activity. Research Journal of Pharmacy and Technology. 2021; 14(9):4983-6. doi: 10.52711/0974-360X.2021.00867

Cite(Electronic):
Amrita Muralikrishnan, Radhika R Nair, Jifitha Banu, Leena K Pappachen. In silico designing of some Benzimidazole derivatives for Anti-fungal activity. Research Journal of Pharmacy and Technology. 2021; 14(9):4983-6. doi: 10.52711/0974-360X.2021.00867   Available on: https://rjptonline.org/AbstractView.aspx?PID=2021-14-9-81


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1.    Felix Bongomin, Sara Gago , Rita O. Oladele and David W. Denning.Global and Multi-National Prevalence of Fungal Diseases—Estimate Precision. Journal of Fungi. 2017; 3(4): 57.
2.    WeijieSi, Tao Zhang, Yaofa Li, Dongmei She, Wenliang Pan, Zhanlin Gao, Jun Ning and Xiangdong Mei.. Synthesis and biological activity of novel benzimidazole derivatives as potential antifungal agents. Journal of Pesticide Science.2016; 41(1): 15–19.
3.    Terry Roemer and Damian J. Krysan. Antifungal Drug Development: Challenges, Unmet Clinical Needs, and New Approaches. Cold Spring Harbor Perspectives in Medicine. 2014; 4.
4.    Denning, D. W., and Hope, W. W. (2010). Therapy for fungal diseases: opportunities and priorities. Trends in Microbiology. 2010; 18(5): 195-204.
5.    Dr Leena K Pappachen, Dr Subin Mary Zachariah and Chandran D. Insilico design, synthesis and characterization of some novel benzothiazole derivatives as anti-cancer agents. Asian Journal of Pharmaceutical and Clinical Research.2017; 10: 150-155.
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